{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T07:05:18Z","timestamp":1765695918746,"version":"3.48.0"},"reference-count":12,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:p>AIMS: To study the expression of HLA-DR antigen in the different histological types of gastric polyps. METHODS: Ninety five cases of gastric polyps were histologically classified and examined for the presence of Helicobacter pylori, and for degree and type of inflammation. Further sections were stained immunohistochemically for HLA-DR antigen expression in the epithelium using a monoclonal antibody that was reactive to formalin-fixed paraffin wax embedded tissue. RESULTS: HLA-DR antigen was expressed in all of the inflammatory polyps studied (20\/20), and in most hyperplastic (12\/16) and adenomatous (4\/6) polyps. Only a few fundic gland polyps (8\/51) stained positively for HLA-DR antigen. Gastric polyps seem to have a greater tendency to express HLA-DR antigens than non-polypoid gastric mucosa, even after considering the factors that may affect HLA-DR antigen expression, such as inflammation and the presence of H pylori. CONCLUSIONS: Growth disturbances\/polyp formation may be associated with increased HLA-DR antigen expression.<\/jats:p>","DOI":"10.1136\/jcp.45.6.509","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"509-512","source":"Crossref","is-referenced-by-count":5,"title":["Expression of HLA-DR antigen in different histological types of gastric polyp."],"prefix":"10.1136","volume":"45","author":[{"given":"A","family":"Wee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Teh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G C","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1136\/jcp.40.9.948","article-title":"The HLA system: structure and function","volume":"40","author":"Bodmer, W.F.","year":"1987","unstructured":"Bodmer WF. The HLA system: structure and function. J Clin Pathol 1987;40:948-58.","journal-title":"J Clin Pathol"},{"key":"ref_2","first-page":"339","article-title":"Tissue distribution of class II transplantation antigens: presence on normal cells","volume-title":"class II antigens. A comprehensive review of structure andfunction","author":"Klareskog, L.; Forsum, U.","year":"1986","unstructured":"Klareskog L, Forsum U. Tissue distribution of class II transplantation antigens: presence on normal cells. In: Solheim BG, Moller E, Ferrone S, eds. HLA class II antigens. A comprehensive review of structure andfunction. Berlin, Heidelberg: Springer-Verlag, 1986:339-55."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/jcp.45.1.30","article-title":"Association of Helicobacter pylori with HLA-DR antigen expression in gastritis","volume":"45","author":"Wee, A.; Teh, M.; Kang, J.Y.","year":"1992","unstructured":"Wee A, Teh M, Kang JY. Association of Helicobacter pylori with HLA-DR antigen expression in gastritis. J Clin Pathol 1992;45:30-3.","journal-title":"J Clin Pathol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/gut.31.6.647","article-title":"Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa","volume":"31","author":"Valnes, K.; Huitfeldt, H.S.; Brandtzaeg, P.","year":"1990","unstructured":"Valnes K, Huitfeldt HS, Brandtzaeg P. Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa. Gut 1990;31:647-52.","journal-title":"Gut"},{"key":"ref_5","article-title":"HLA-DR antigen expression in intestinaltype and diffuse-type gastric carcinoma","author":"Teh, M.; Lee, Y.S.","year":"1992","unstructured":"Teh M, Lee YS. HLA-DR antigen expression in intestinaltype and diffuse-type gastric carcinoma. Cancer 1992 (in press).","journal-title":"Cancer"},{"key":"ref_6","first-page":"79","article-title":"Localized and extensive expansions of the gastric mucosa: mucosal polyps and giant folds","volume":"4","author":"Appleman, H.D.","year":"1984","unstructured":"Appleman HD. Localized and extensive expansions of the gastric mucosa: mucosal polyps and giant folds. In: Appleman HD, ed. Pathology ofthe esophagus, stomach and duodenum. Contemporary issues in surgicalpathology, vol 4. New York: Churchill Livingstone, 1984:79-119.","journal-title":"Contemporary issues in surgicalpathology; Pathology ofthe esophagus, stomach and duodenum"},{"key":"ref_7","first-page":"221","article-title":"Gastric polyps; their morphological and endoscopical characteristics and relation to gastric carcinoma","volume":"90","author":"Laxen, F.; Sipponen, P.; Ihamaki, T.; Hakkiluoto, A.; Dortscheva, Z.","year":"1982","unstructured":"Laxen F, Sipponen P, Ihamaki T, Hakkiluoto A, Dortscheva Z. Gastric polyps; their morphological and endoscopical characteristics and relation to gastric carcinoma. Acta Pathol Microbiol Immunol Scand 1982;90:221-8.","journal-title":"Acta Pathol Microbiol Immunol Scand"},{"key":"ref_8","first-page":"1093","article-title":"Gastroduodenal mucosa in uraemia: endoscopic and histological correlation and prevalence of helicobacter-like organisms","volume":"10","author":"Wee, A.; Kang, J.Y.; Ho, M.S.; Choong, H.L.; Wu, A.Y.T.; Sutherland, I.H.","year":"1990","unstructured":"Wee A, Kang JY, Ho MS, Choong HL, Wu AYT, Sutherland IH. Gastroduodenal mucosa in uraemia: endoscopic and histological correlation and prevalence of helicobacter-like organisms. Gut 1990;10:1093-6.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/bmj.293.6548.645","article-title":"Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate","volume":"293","author":"McNulty, C.A.M.; Gearty, J.C.; Crump, B.","year":"1986","unstructured":"McNulty CAM, Gearty JC, Crump B, et al. Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J 1986;293:645-9.","journal-title":"Br Med J"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1136\/gut.31.8.850","article-title":"Helicobacter pylori and gastritis in patients with peptic ulcer and non-ulcer dyspepsia: ethnic differences in Singapore","volume":"31","author":"Kang, J.Y.; Wee, A.; Math, M.V.","year":"1990","unstructured":"Kang JY, Wee A, Math MV, et al. Helicobacter pylori and gastritis in patients with peptic ulcer and non-ulcer dyspepsia: ethnic differences in Singapore. Gut 1990; 31:850-3.","journal-title":"Gut"},{"key":"ref_11","first-page":"2824","article-title":"Peptide growth factors PDGF, EGF, and FGF regulate immune interferon production","volume":"134","author":"Johnson, H.M.; Torres, B.A.","year":"1985","unstructured":"Johnson HM, Torres BA. Peptide growth factors PDGF, EGF, and FGF regulate immune interferon production. J Immunol 1985;134:2824-6.","journal-title":"J Immunol"},{"key":"ref_12","first-page":"9","article-title":"Effects of PDGF and EGF on antigen-induced proliferation of human T-cell lines","volume":"54","author":"Acres, R.B.; Lam, JR, Feldman; M.","year":"1985","unstructured":"Acres RB, Lam JR, Feldman M. Effects of PDGF and EGF on antigen-induced proliferation of human T-cell lines. 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