{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:08:33Z","timestamp":1782522513616,"version":"3.54.5"},"reference-count":30,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:p>AIMS: To investigate whether Helicobacter pylori infection or autoimmune gastritis is responsible for the reported increase in gastric pathology and abnormalities of gastric function in patients with coeliac disease and dermatitis herpetiformis (DH). METHODS: Serum H pylori IgG antibodies were assayed by enzyme linked immunosorbent assay and intrinsic factor antibodies by radioimmunoassay in 99 patients with coeliac disease and 58 patients with dermatitis herpetiformis from two geographic areas. RESULTS: H pylori positivity in patients with coeliac disease and dermatitis herpetiformis increased with age, reaching 50% and 70%, respectively, in patients over 50 years. The percentage H pylori seropositivity in coeliac disease did not differ from the percentage positivity observed in 250 similarly aged blood donors from the same geographic area (Leeds). Seropositivity in patients with dermatitis herpetiformis was not significantly different from the level of positivity observed in 98 age matched patients without dermatitis herpetiformis attending the same Edinburgh dermatology clinic. Only one patient with coeliac disease had positive intrinsic factor antibodies. H pylori seropositivity in Edinburgh control subjects under 30 years of age (41.9%) was significantly higher (p less than 0.03) than in Leeds controls (18%) of corresponding age. An increasing prevalence of H pylori seropositivity with age in coeliac disease and dermatitis herpetiformis paralleled that of the control groups. CONCLUSIONS: Gastritis in coeliac disease and dermatitis herpetiformis is largely caused by H pylori infection at a level that is no different from that of the general population. Any increase in the prevalence of gastritis in these two diseases might be caused by lymphocytic gastritis rather than pernicious anaemia.<\/jats:p>","DOI":"10.1136\/jcp.45.7.597","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"597-600","source":"Crossref","is-referenced-by-count":34,"title":["Helicobacter pylori serology in patients with coeliac disease and dermatitis herpetiformis."],"prefix":"10.1136","volume":"45","author":[{"given":"J E","family":"Crabtree","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"O'Mahony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R V","family":"Heatley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Vestey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P D","family":"Howdle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B J","family":"Rathbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Losowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"ref_1","first-page":"49","article-title":"Gastric studies","volume-title":"idiopathic steatorrhea. Gastroenterology 1963; 45","author":"Hansky, J.; Shiner, M.","unstructured":"Hansky J, Shiner M. Gastric studies in idiopathic steatorrhea. Gastroenterology 1963;45:49-56."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/00365528509089645","article-title":"Gastric morphology and function in dermatitis herpetiformis and in coeliac disease","volume":"20","author":"Gillberg, R.; Kastrup, W.; Mobacken, H.; Stockbrugger, R.; Ahren, C.","year":"1985","unstructured":"Gillberg R, Kastrup W, Mobacken H, Stockbrugger R, Ahren C. Gastric morphology and function in dermatitis herpetiformis and in coeliac disease. ScandJ Gastroenterol 1985;20: 133-40.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/gut.17.3.185","article-title":"Gastric lesion in dermatitis herpetiformis","volume":"17","author":"O'Donoghue, D.P.; Lancaster-Smith, M.; Johnson, G.D.; Kumar, P.J.","year":"1976","unstructured":"O'Donoghue DP, Lancaster-Smith M, Johnson GD, Kumar PJ. Gastric lesion in dermatitis herpetiformis. Gut 1976;17: 185-8.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/00365529009095499","article-title":"Gastric histology and function tests in Italian patients with dermatitis herpetiformis","volume":"25","author":"Primignani, M.; Agape, D.; Ronchi, G.","year":"1990","unstructured":"Primignani M, Agape D, Ronchi G, et al. Gastric histology and function tests in Italian patients with dermatitis herpetiformis. Scand J Gastroenterol 1990;25:357-62.","journal-title":"Scand J Gastroenterol"},{"key":"ref_5","first-page":"261","article-title":"Malabsorption of vitamin B12 in dermatitis herpetiformis and its association with pernicious anaemia","volume":"220","author":"KastrupW, Mobacken H.; R, Stockbrugger; B, Swolin; J, Westin","year":"1986","unstructured":"KastrupW, Mobacken H, Stockbrugger R, Swolin B,Westin J. Malabsorption of vitamin B12 in dermatitis herpetiformis and its association with pernicious anaemia. Acta Med Scand 1986;220:261-8.","journal-title":"Acta Med Scand"},{"key":"ref_6","first-page":"343","article-title":"Development of gastric dysfunction in dermatitis herpetiformis","volume":"158","author":"Stockbrugger, R.; Kastrup, W.; Lundquist, G.; Mobacken, H.","year":"1978","unstructured":"Stockbrugger R, Kastrup W, Lundquist G, Mobacken H. Development of gastric dysfunction in dermatitis herpetiformis. 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H pylori carriage in patients with intestinal metaplasia and in endoscopical-proven normal controls. Rev Esp Enferm Digr 1990;78(suppl 1):83.","journal-title":"Rev Esp Enferm Digr"},{"key":"ref_17","first-page":"768","article-title":"Immune responses to Helicobacter pylori in children with recurrent abdominal pain","volume":"4","author":"Crabtree, J.E.; Mahony, M.J.; Taylor, J.D.; Heatley, R.V.; Littlewood, J.M.; Tompkins, D.S.","year":"1991","unstructured":"Crabtree JE, Mahony MJ, Taylor JD, Heatley RV, Littlewood JM, Tompkins DS. 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Local immunoglobulin production is different in gastritis associated with dermatitis herpetiformis and simple gastritis","volume":"28","author":"Valnes, K.; Brandtzaeg, P.; Elgjo, K.; Stave, R.; Bekelin, K.","year":"1987","unstructured":"Valnes K, Brandtzaeg P, Elgjo K, Stave R, Bekelin K, Fausa 0. Local immunoglobulin production is different in gastritis associated with dermatitis herpetiformis and simple gastritis. Gut 1987;28:1589-94.","journal-title":"Gut"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/0140-6736(90)93029-O","article-title":"Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease","volume":"335","author":"O'Mahony, S.; Vestey, J.P.; Ferguson, A.","year":"1990","unstructured":"O'Mahony S, Vestey JP, Ferguson A. Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease. Lancet 1990;335: 1487-90.","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/gut.30.3.347","article-title":"Immunoglobulin secretion by isolated intestinal lymphocytes: spontaneous production and T-cell regulation in normal small intestine and in patients with coeliac disease","volume":"30","author":"Crabtree, J.E.; Heatley, R.V.; Losowsky, M.S.","year":"1989","unstructured":"Crabtree JE, Heatley RV, Losowsky MS. Immunoglobulin secretion by isolated intestinal lymphocytes: spontaneous production and T-cell regulation in normal small intestine and in patients with coeliac disease. Gut 1989; 30:347-54.","journal-title":"Gut"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/gut.32.1.29","article-title":"Dissociation between systemic and mucosal humoral responses in coeliac disease","volume":"32","author":"O'Mahony, S.; Arranz, E.; Barton, JR, Ferguson; A.","year":"1991","unstructured":"O'Mahony S, Arranz E, Barton JR, Ferguson A. Dissociation between systemic and mucosal humoral responses in coeliac disease. Gut 1991;32:29-35.","journal-title":"Gut"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/path.1711540204","article-title":"Lymphocytic gastritis-relationship to Campylobacter infection","volume":"154","author":"Dixon, M.F.; Wyatt, J.I.; Burke, D.A.; Rathbone, B.J.","year":"1988","unstructured":"Dixon MF, Wyatt JI, Burke DA, Rathbone BJ. Lymphocytic gastritis-relationship to Campylobacter infection. Pathol 1988;154:125-32.","journal-title":"Pathol"},{"key":"ref_26","first-page":"243","article-title":"Coeliac disease","volume-title":"defences in clinical practice","author":"Howdle, P.D.; Losowsky, M.S.","year":"1986","unstructured":"Howdle PD, Losowsky MS. Coeliac disease. In: Losowsky MS, Heatley RV, eds. Gut defences in clinical practice. Edinburgh: Churchill Livingstone, 1986;243-54."},{"key":"ref_27","first-page":"29","article-title":"Studies of intestinal lymphoid tissue. XII. Epithelial lymphocyte and mucosal responses to rectal gluten challenge","volume-title":"celiac sprue. Gastroenterology 1989; 97","author":"Loft, D.E.; Marsh, M.N.; Sandle, G.I.","unstructured":"Loft DE, Marsh MN, Sandle GI, et al. Studies of intestinal lymphoid tissue. XII. Epithelial lymphocyte and mucosal responses to rectal gluten challenge in celiac sprue. Gastroenterology 1989;97:29-37."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/00365528509089630","article-title":"Influence of gluten-free diet on the gastric condition in dermatitis herpetiformis","volume":"20","author":"Kastrup, W.; Andersson, H.; Gillberg, R.; Mobacken, H.; Stockbrugger, R.","year":"1985","unstructured":"Kastrup W, Andersson H, Gillberg R, Mobacken H, Stockbrugger R. Influence of gluten-free diet on the gastric condition in dermatitis herpetiformis. Scand Gastroenterol 1985;20:39-45.","journal-title":"Scand Gastroenterol"},{"key":"ref_29","first-page":"507","article-title":"The immunology of coeliac disease. Bailliere's Clin Gastroenterol","volume":"1","author":"Howdle, P.D.; Losowsky, M.S.","year":"1987","unstructured":"Howdle PD, Losowsky MS. The immunology of coeliac disease. Bailliere's Clin Gastroenterol 1987;1:507-29."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/gut.24.3.228","article-title":"Effect of gluten-free diet on splenic hypofunction in adult coeliac disease","volume":"24","author":"Corazza, G.R.; Frisoni, M.; Vaira, D.; Gasbarrini, G.","year":"1983","unstructured":"Corazza GR, Frisoni M, Vaira D, Gasbarrini G. Effect of gluten-free diet on splenic hypofunction in adult coeliac disease. 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