{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:54:41Z","timestamp":1760853281307,"version":"3.44.0"},"reference-count":30,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>AIMS: To determine whether the expression of proliferating cell nuclear antigen (PCNA) in villous cytotrophoblast could distinguish between placental tissue from a hydropic abortion and that from a partial hydatidiform mole. METHODS: Tissue from 18 partial hydatidiform moles, 15 hydropic abortions, five normal first trimester placentas and five normal full term placentas were immunostained for expression of PCNA, using the monoclonal antibody PC10. RESULTS: PCNA immunoreactivity was very much higher in the cytotrophoblast of normal first trimester placentas than in normal term placentas. Villous tissue from partial hydatidiform moles showed, on average, less immunoreactivity for PCNA than did villous tissue from hydropic abortions. CONCLUSIONS: Immunostaining for PCNA is of no value for differentiating between partial hydatidiform moles and hydropic abortions. The findings indicate that trophoblastic proliferation or hyperplasia is not a feature of partial hydatidiform moles.<\/jats:p>","DOI":"10.1136\/jcp.46.1.48","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"48-50","source":"Crossref","is-referenced-by-count":22,"title":["Use of proliferation cell nuclear antigen immunoreactivity for distinguishing hydropic abortions from partial hydatidiform moles."],"prefix":"10.1136","volume":"46","author":[{"given":"U R","family":"Suresh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Hale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1471-0528.1979.tb10793.x","article-title":"Discrepancies in the histological diagnosis of hydatidiform mole","volume":"86","author":"Javey, H.; Borazjani, G.; Behmard, S.; Langley, F.A.","year":"1979","unstructured":"Javey H, Borazjani G, Behmard S, Langley FA. Discrepancies in the histological diagnosis of hydatidiform mole. Br Jf Obstet Gynaecol 1979;86:480-3.","journal-title":"Br Jf Obstet Gynaecol"},{"key":"ref_2","first-page":"622","article-title":"Interand intra-pathologist variability in the diagnosis of gestational trophoblastic neoplasia","volume":"69","author":"Messerli, M.L.; Parmley, T.; Woodruff, J.D.; Lilienfeld, A.M.; Bevilacqua, L.; Rosenheim, N.B.","year":"1987","unstructured":"Messerli ML, Parmley T, Woodruff JD, Lilienfeld AM, Bevilacqua L, Rosenheim NB. Interand intra-pathologist variability in the diagnosis of gestational trophoblastic neoplasia. Obstet Gynaecol 1987;69:622-6.","journal-title":"Obstet Gynaecol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0306-3356(21)00602-6","article-title":"The pathology of trophoblastic disease: current status","volume":"11","author":"Elston, C.W.","year":"1984","unstructured":"Elston CW. The pathology of trophoblastic disease: current status. Clinics Obstet Gynaecol 1984;11:135-52.","journal-title":"Clinics Obstet Gynaecol"},{"key":"ref_4","first-page":"183","article-title":"Trophoblastic disease: complete and partial hydatidiform moles","volume-title":"Pathology of the placenta","author":"Szulman, A.E.","year":"1984","unstructured":"Szulman AE. Trophoblastic disease: complete and partial hydatidiform moles. In: Perrin EVDK, ed. Pathology of the placenta. New York: Churchill Livingstone, 1984: 183-97. Suresh, Hale, Fox, Buckley"},{"key":"ref_5","first-page":"1045","article-title":"Gestational trophoblastic disease","volume-title":"atnd Taylor: obstetrical and gynaecological pathology","author":"Elston, C.W.","year":"1987","unstructured":"Elston CW. Gestational trophoblastic disease. In: Fox H, ed. Haiomes atnd Taylor: obstetrical and gynaecological pathology. Edinburgh: Churchill Livingstone, 1987:1045-78."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-1-4471-1658-5_41","article-title":"The biology of trophoblastic disease: complete and partial hydatidiform moles","volume-title":"pregnancy loss: niechanisnms and treatnient","author":"Szulman, A.E.","year":"1988","unstructured":"Szulman AE. The biology of trophoblastic disease: complete and partial hydatidiform moles. In: Beard RW, Sharp F, eds. Early pregnancy loss: niechanisnms and treatnient. London: Springer-Verlag, 1988:309-18."},{"issue":"71","key":"ref_7","article-title":"Trophoblastic disease: a review' with emphasis on recent advances and problems in differential diagnosis","volume-title":"int reproductive and urinary tract pathology, Vol 1","volume":"31","author":"Elston, C.W.","year":"1990","unstructured":"Elston CW. Trophoblastic disease: a review' with emphasis on recent advances and problems in differential diagnosis. In: Dam;anov I, Cohen AH, Mills SE, Young RH, eds. Progress int reproductive and urinary tract pathology, Vol 1. New York: Field & Wood, 1990:31 -71."},{"key":"ref_8","first-page":"1","article-title":"Gestational trophoblastic disease","volume-title":"Surgical pathology of the feniale reproductive svsteni and peritoneum","author":"Mazur, M.T.; Kurman, R.J.","year":"1991","unstructured":"Mazur MT, Kurman RJ. Gestational trophoblastic disease. In: Sternberg SS, Mills SE, eds. Surgical pathology of the feniale reproductive svsteni and peritoneum. NewYork: Raven Press, 1991:1-16."},{"key":"ref_9","first-page":"195","article-title":"Pathology of trophoblast","volume-title":"Pathology of reproductive failure","author":"Kurman, R.J.","year":"1991","unstructured":"Kurman RJ. Pathology of trophoblast. In: Kraus FT, Damjanov I, Kaufman N, eds. Pathology of reproductive failure. Baltimore: Williams & Wilkins, 1991:195-227."},{"key":"ref_10","first-page":"1013","article-title":"Pathology and classification of trophoblastic tumours","volume-title":"oncology","author":"Paradinas, F.J.","year":"1992","unstructured":"Paradinas FJ. Pathology and classification of trophoblastic tumours. In: Coppleson M, ed. Gynaecologic oncology. 2nd ed. Edinburgh: Churchill Livingstone, 1992:1013-26.","edition":"2nd ed"},{"key":"ref_11","first-page":"374","article-title":"Identity of the proliferating cell nuclear antigen and cyclin","volume":"303","author":"Matthews, M.B.; Berstein, R.M.; BR, Jr, Franza; Garrels, J.I.","year":"1984","unstructured":"Matthews MB, Berstein RM, Franza BR Jr, Garrels JI. Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984;303:374-6.","journal-title":"Nature"},{"key":"ref_12","first-page":"3262","article-title":"Cell cycle dependent variations in the distribution of the proliferating cell nuclear antigen in cultured cells: subdivision","volume-title":"of S phase. Proc NatlAcad Sci USA","volume":"82","author":"Celis, J.E.; Celis, A.","year":"1985","unstructured":"Celis JE, Celis A. Cell cycle dependent variations in the distribution of the proliferating cell nuclear antigen in cultured cells: subdivision of S phase. Proc NatlAcad Sci USA 1985;82:3262-6."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/326515a0","article-title":"Cyclin\/PCNA is the auxiliary protein of DNA delta","volume":"326","author":"Bravo, R.; Frank, R.; Blundell, P.A.; MacDonald-Bravo, H.","year":"1987","unstructured":"Bravo R, Frank R, Blundell PA, MacDonald-Bravo H. Cyclin\/PCNA is the auxiliary protein of DNA delta. Nature 1987;326:515-7.","journal-title":"Nature"},{"key":"ref_14","first-page":"15","article-title":"Autoantibody to the proliferating cell nuclear antigen neutralises the activity of the auxiliary protein for polymerase delta","volume":"1987","author":"Tan, C.K.; Sullivan, K.; Li, X.Y.; Tan, E.M.; Downey, K.M.; So, A.G.","unstructured":"Tan CK, Sullivan K, Li XY, Tan EM, Downey KM, So AG. Autoantibody to the proliferating cell nuclear antigen neutralises the activity of the auxiliary protein for polymerase delta. Nucleic Acids Res 1987:15:9299-308.","journal-title":"Nucleic Acids Res"},{"issue":"121 -9","key":"ref_15","article-title":"Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA): structural conservation and the detection of a nucleolar form..7 Cell","volume":"96","author":"Waseem, N.H.; Lane, D.P.","year":"1990","unstructured":"Waseem NH, Lane DP. 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Pathol 1990;162:285-94.","journal-title":"Pathol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1128\/MCB.9.1.57","article-title":"Involvement of proliferating cell nuclear antigen (cyclin) in DNA replication in living cells","volume":"9","author":"Zuber, M.; Tan, E.M.; Ryoji, M.","year":"1989","unstructured":"Zuber M, Tan EM, Ryoji M. Involvement of proliferating cell nuclear antigen (cyclin) in DNA replication in living cells. Mol Cell Biol 1989;9:57-66.","journal-title":"Mol Cell Biol"},{"key":"ref_18","first-page":"733","article-title":"Analysis of proliferative grade using anti-PCNA-cyclin monoclonal antibodies in fixed, embedded tissues: comparison with flow cytometric analysis","volume":"134","author":"Garcia, R.L.; Coltrera, M.D.; Gown, A.M.","year":"1989","unstructured":"Garcia RL, Coltrera MD, Gown AM. Analysis of proliferative grade using anti-PCNA-cyclin monoclonal antibodies in fixed, embedded tissues: comparison with flow cytometric analysis. Am Pathol 1989;134:733-9.","journal-title":"Am Pathol"},{"key":"ref_19","first-page":"184","article-title":"Assessment of cellular proliferation in histological material: Clin Pathol","volume":"43","author":"Hall, P.A.; Levison, D.A.","year":"1990","unstructured":"Hall PA, Levison DA. Assessment of cellular proliferation in histological material: Clin Pathol 1990;43:184-92."},{"key":"ref_20","first-page":"531","article-title":"Immunohistochemical markers of cell proliferation: achievements, problems and prospects","volume":"23","author":"Hall, P.A.; Woods, P.A.","year":"1990","unstructured":"Hall PA, Woods PA. Immunohistochemical markers of cell proliferation: achievements, problems and prospects. Cell Tissue Kinet 1990;23:531-49.","journal-title":"Cell Tissue Kinet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2559.1991.tb00890.x","article-title":"The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S+G2+M phase fraction (flow cytometric analysis) and prognosis","volume":"19","author":"Woods, A.L.; Hall, P.A.; Shepherd, N.A.","year":"1991","unstructured":"Woods AL, Hall PA, Shepherd NA, et al. The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S+G2+M phase fraction (flow cytometric analysis) and prognosis. Histopathology, 1991;19:21-7.","journal-title":"Histopathology"},{"key":"ref_22","first-page":"1256","article-title":"Analysis of variance and distribution-free methods","volume":"41","year":"1988","unstructured":"Analysis of variance and distribution-free methods. _7 Clin Pathol 1988;41: 1256-62."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0306-3356(21)00030-3","article-title":"Pathology of the placenta","volume":"13","author":"Fox, H.","year":"1986","unstructured":"Fox H. Pathology of the placenta. Clinics Obstet GnLaecol 1986;13:501-19.","journal-title":"Clinics Obstet GnLaecol"},{"issue":"31 -7","key":"ref_24","article-title":"Regionale unterschiedliche Zellproliferation innerhalb der Plazentome reifer menschlichen Plazenten: autoradiographische Untersuchungen","volume":"218","author":"Geier, G.; Schuhmann, R.; Kraus, H.","year":"1975","unstructured":"Geier G, Schuhmann R, Kraus H. Regionale unterschiedliche Zellproliferation innerhalb der Plazentome reifer menschlichen Plazenten: autoradiographische Untersuchungen. Arch Gynakol 1975;218:31 -7.","journal-title":"Arch Gynakol"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0143-4004(85)80028-X","article-title":"Continuing growth and development of the third trimester human placenta","volume":"6","author":"Sands, J.; Dobbing, J.","year":"1985","unstructured":"Sands J, Dobbing J. Continuing growth and development of the third trimester human placenta. Placenta 1985;6: 13-22.","journal-title":"Placenta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3109\/00016348509156370","article-title":"Flow cytometry in the assessment of human placental growth","volume":"64","author":"Iversen, O.E.; FarsundT","year":"1985","unstructured":"Iversen OE, FarsundT. Flow cytometry in the assessment of human placental growth. Acta Obstet Gvnaecol Scandinavica 1985;64:605-7.","journal-title":"Acta Obstet Gvnaecol Scandinavica"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0378-3782(84)90074-4","article-title":"Quantitative studies of the normal human placenta from 10 weeks of gestation to term","volume":"9","author":"Boyd, P.A.","year":"1984","unstructured":"Boyd PA. Quantitative studies of the normal human placenta from 10 weeks of gestation to term. Early Huni Develop 1984;9:297-307.","journal-title":"Early Huni Develop"},{"key":"ref_28","first-page":"670","article-title":"The placenta","volume-title":"endocrine pathology","author":"Fox, H.","year":"1991","unstructured":"Fox H. The placenta. In: Kovacs K, Asa SL, eds. Funictional endocrine pathology. Oxford: Blackwell Scientific Publications, 1991:670-82."},{"key":"ref_29","first-page":"1165","article-title":"Cell-cycle-related patterns of antiproliferating cell nuclear antigen monoclonal antibodies: comparison with BrdUrd labelling and Ki-67","volume":"138","author":"van Dierendonck JH; JH, Wijsman; R, Keilser; van der Velde CJ; CJ, Cornelisse","year":"1991","unstructured":"van Dierendonck JH, Wijsman JH, Keilser R, van der Velde CJ, Cornelisse CJ. Cell-cycle-related patterns of antiproliferating cell nuclear antigen monoclonal antibodies: comparison with BrdUrd labelling and Ki-67. Anm Pathol 1991;138:1165-72.","journal-title":"Anm Pathol"},{"key":"ref_30","first-page":"173","article-title":"A comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fraction","volume":"165","author":"Scott, R.J.; Hall, P.A.; Haldane, J.S.","year":"1991","unstructured":"Scott RJ, Hall PA, Haldane JS, et al. 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