{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:55:57Z","timestamp":1758794157312,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>AIMS: To assess the incidence of foreign body giant cell reactions and ossification in benign\/melanocytic naevi; and to examine their pathological features to gain an insight into their pathogenesis. METHODS: Intradermal (n = 185) and compound naevi (n = 110) from a routine histology service, together with 60 naevi submitted to an ophthalmic pathologist, were examined for foreign body reactions and ossification. Additional cases were identified prospectively in the course of routine reporting. The clinical and pathological features of positive cases were assessed. RESULTS: Foreign body reactions were identified in nine (4.9%) intradermal and four (3.6%) compound naevi, but in none of the naevi from around the eye. One intradermal naevus showed ossification. A further 11 naevi showing foreign body reaction and five showing ossification alone were identified prospectively. The 24 naevi showing a foreign body reaction had a similar age and sex distribution to controls but were more likely to occur on the head and neck. The reaction usually occurred deep to the naevus, sometimes in relation to a hair follicle, and fragments of hair or keratin were identified in most. Osteoid or bone was present within the reaction in five. In six other naevi, all from the head and neck of women, osteoid or mature bone was present deep to the naevus in the absence of a giant cell reaction. CONCLUSIONS: Foreign body giant cell reactions occur not uncommonly in relation to benign naevi, as a result of follicular damage, possibly due to trauma. The similar siting of foci of bone suggests that ossification occurs as a secondary phenomenon in these cases.<\/jats:p>","DOI":"10.1136\/jcp.46.1.72","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"72-74","source":"Crossref","is-referenced-by-count":12,"title":["Foreign body giant cell reactions and ossification associated with benign melanocytic naevi."],"prefix":"10.1136","volume":"46","author":[{"given":"W F","family":"Knox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L J","family":"McWilliam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E W","family":"Benbow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Bonshek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,1,1]]},"reference":[{"key":"ref_1","article-title":"An introduction to the diagnostic histopathology of the skin","volume-title":"always in lesions from the face.9-\" In the 29 intradermal naevi with ossification reported by Roth et al' the bone was nearly always at the base or to one side of the naevus, and in five cases there was associated inflammation with foreign body giant cells","author":"Milne, J.A.","year":"1972","unstructured":"Milne JA. An introduction to the diagnostic histopathology of the skin. London: Edward Arnold, 1972. always in lesions from the face.9-\" In the 29 intradermal naevi with ossification reported by Roth et al' the bone was nearly always at the base or to one side of the naevus, and in five cases there was associated inflammation with foreign body giant cells."},{"key":"ref_2","article-title":"Histopathology of the skin","author":"Lever, W.F.; Schaumburg-Lever, G.","year":"1983","unstructured":"Lever WF, Schaumburg-Lever G. Histopathology of the skin. Philadelphia: JB Iippincott Co, 1983."},{"key":"ref_3","article-title":"Pathology of the skin with clinical correlations","author":"McKee, P.H.","year":"1989","unstructured":"McKee PH. Pathology of the skin with clinical correlations. London: Gower Medical Publishing, 1989."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1600-0560.1982.tb01065.x","article-title":"Unusual features of nevocellular naevi","volume":"9","author":"Weedon, D.","year":"1982","unstructured":"Weedon D. Unusual features of nevocellular naevi. Jf Cutan Pathol 1982;9:284-92.","journal-title":"Jf Cutan Pathol"},{"issue":"85","key":"ref_5","first-page":"72","article-title":"Epidermal cysts associated with pigmented naevi","volume":"1962","author":"Freeman, R.G.; Knox, J.M.","unstructured":"Freeman RG, Knox JM. Epidermal cysts associated with pigmented naevi. Arch Dermatol 1962;85:72-6.","journal-title":"Arch Dermatol"},{"issue":"1","key":"ref_6","first-page":"11","article-title":"On the association of granulomas with simple The histological appearances of the foreign body reactions in our study support an association with follicular damage. Most occurred at the level of hair follicles and most contained hair or keratin. Fibrosis did not appear to be a noticeable feature; any follicular distortion or cutaneous moles","volume":"36","author":"Currie, A.R.","year":"1955","unstructured":"Currie AR. On the association of granulomas with simple The histological appearances of the foreign body reactions in our study support an association with follicular damage. Most occurred at the level of hair follicles and most contained hair or keratin. Fibrosis did not appear to be a noticeable feature; any follicular distortion or cutaneous moles. Glasgow Med 1955;36:1 11-16.","journal-title":"Glasgow Med"},{"issue":"74","key":"ref_7","first-page":"224","article-title":"Some observations on common moles","volume":"1962","author":"Haber, H.","unstructured":"Haber H. Some observations on common moles. Br Dermatol 1962;74:224-8.","journal-title":"Br Dermatol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/archderm.1957.01550200033007","article-title":"Abscess formation in pigmented nevi. Report of three cases","volume":"76","author":"Saunders, T.S.","year":"1957","unstructured":"Saunders TS. Abscess formation in pigmented nevi. Report of three cases. Arch Dermatol 1957;76:189-92.","journal-title":"Arch Dermatol"},{"key":"ref_9","first-page":"56","article-title":"Cutaneous ossification","volume":"76","author":"Roth, S.I.; Stowell, R.E.; Helwig, E.B.","year":"1963","unstructured":"Roth SI, Stowell RE, Helwig EB. Cutaneous ossification. Arch Pathol 1963;76:56-66.","journal-title":"Arch Pathol"},{"article-title":"Zur pathogenese des osteonaevus Nanta. Hautarzt 1964; 1S: 487-9. obstruction was likely to be due to the mass of naevus cells around the follicles","author":"Delacretaz, J.; Frenk, E.","key":"ref_10","unstructured":"Delacretaz J, Frenk E. Zur pathogenese des osteonaevus Nanta. Hautarzt 1964;1S:487-9. obstruction was likely to be due to the mass of naevus cells around the follicles. Many of the"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00561117","article-title":"Cutaneous osteomas: a clinical and histopathologic review","volume":"260","author":"BurgdorfW, Nasemann T.","year":"1977","unstructured":"BurgdorfW, Nasemann T. Cutaneous osteomas: a clinical and histopathologic review. Arch Derm Res 1977;260: 121-35.","journal-title":"Arch Derm Res"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.46.1.72","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:08:42Z","timestamp":1758791322000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.46.1.72"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1993,1,1]]},"published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1136\/jcp.46.1.72"],"URL":"https:\/\/doi.org\/10.1136\/jcp.46.1.72","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}