{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:31:11Z","timestamp":1765009871739,"version":"3.46.0"},"reference-count":10,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>This study aimed to determine the diagnostic utility of mast cell densities in distinguishing neurotised (\"neural\") melanocytic naevi from neurofibromas. Three groups of lesions were studied: neurofibromas, neural naevi, and naevi showing no neural change (control naevi). A Giemsa stain was used to demonstrate mast cells. The median mast cell density in the neurotised naevus group was significantly higher (p &lt; 0.005) than that of both the neurofibroma and control naevus groups, but the distributions of the individual density counts overlapped considerably. The sensitivity and specificity of the mast cell density as a potential discriminator between neurotised naevi and neurofibromas, determined in relation to the optimal discrimination value obtained using Bayes' minimum cost decision rule, were low. It is concluded that mast cell density on its own is of little use as a classification tool but could be of value in the context of a multivariate decision rule.<\/jats:p>","DOI":"10.1136\/jcp.46.1.86","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"86-87","source":"Crossref","is-referenced-by-count":14,"title":["Mast cell numbers in melanocytic naevi and cutaneous neurofibromas."],"prefix":"10.1136","volume":"46","author":[{"given":"N J","family":"Carr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Y","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,1,1]]},"reference":[{"key":"ref_1","first-page":"13","article-title":"Melanocytic naevi and malignant melanoma","volume-title":"Pathology of the skin with clinical correlations","author":"McKee, P.H.","year":"1989","unstructured":"McKee PH. Melanocytic naevi and malignant melanoma. In: McKee PH, ed. Pathology of the skin with clinical correlations. Philadelphia: JB Lippincott, 1989: 13.1-13.36."},{"key":"ref_2","article-title":"Histopathology of the skin","author":"LeverWT, Schaumburg-Lever G.","year":"1989","unstructured":"LeverWT, Schaumburg-Lever G. Histopathology of the skin. 7th edn. Philadelphia: JB Lippincott, 1989.","edition":"7th edn"},{"key":"ref_3","first-page":"49","article-title":"Age-related changes in melanocytic naevi. Clin Exp Dermatol","volume":"4","author":"Maize, J.C.; Foster, G.","year":"1979","unstructured":"Maize JC, Foster G. Age-related changes in melanocytic naevi. Clin Exp Dermatol 1979;4:49-58."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1001\/archderm.1949.01530010047004","article-title":"Diagnosis and treatment of pigmented nevi","volume":"60","author":"Becker, S.W.","year":"1949","unstructured":"Becker SW Diagnosis and treatment of pigmented nevi. Arch Dermatol Syph 1949;60:44-65.","journal-title":"Arch Dermatol Syph"},{"issue":"34","key":"ref_5","first-page":"59","article-title":"Nerve fibres: a neglected component of intradermal cellular nevi","volume":"1960","author":"Shelley, W.B.; Arthur, R.P.","unstructured":"Shelley WB, Arthur RP. Nerve fibres: a neglected component of intradermal cellular nevi. J Invest Dermatol 1960;34:59-65.","journal-title":"J Invest Dermatol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1001\/archderm.1984.01650380070013","article-title":"A survey of cutaneous neural lesions for the presence of myelin basic protein","volume":"120","author":"Penneys, N.S.; Mogollon, R.; Kowalczyk, A.; Nadji, M.; Adachi, K.","year":"1984","unstructured":"Penneys NS, Mogollon R, Kowalczyk A, Nadji M, Adachi K. A survey of cutaneous neural lesions for the presence of myelin basic protein. 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Arch Dermatol Forsch 1974;251:55-60.","journal-title":"Arch Dermatol Forsch"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.46.1.86","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:28:21Z","timestamp":1765009701000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.46.1.86"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1993,1,1]]},"published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1136\/jcp.46.1.86"],"URL":"https:\/\/doi.org\/10.1136\/jcp.46.1.86","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}