{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:30:27Z","timestamp":1765081827310,"version":"3.46.0"},"reference-count":30,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:p>A case of abnormal chromatin clumping (ACC) which arose during the course of a myelodysplastic\/myeloproliferative syndrome is described in a 61 year old woman who died of haemorrhage 43 months after diagnosis. Mature granulocytes exhibited the same nuclear abnormality described in other patients reported. Unusually, she presented with advanced splenomegaly and lymphadenopathy. This case was the third example of ACC in lymphocytes, the first with clinically confirmed lymphadenopathy. Diagnosis of this subset can be based on: older age; short duration of symptoms; no specific karyotypic damage; non-rearranged bcr; proliferative growth pattern in vitro; numerous circulating myelocytes; profound thrombocytopenia.<\/jats:p>","DOI":"10.1136\/jcp.46.2.177","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"177-179","source":"Crossref","is-referenced-by-count":1,"title":["Lymph node disease with lymphocytic abnormal chromatin clumping in a myelodysplastic\/myeloproliferative syndrome."],"prefix":"10.1136","volume":"46","author":[{"given":"J","family":"Gardais","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2141.1988.tb02433.x","article-title":"The syndrome of abnormal chromatin clumping in leucocytes: a myelodysplastic disorder with proliferative features?","volume":"70","author":"true","year":"1988","unstructured":"Felman P, Bryon PA, Gentilhomme 0, et al. 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Blood 1988;71:349-55."},{"key":"ref_5","first-page":"3026","article-title":"Hemopathie maligne de type aplastique avec anomalies nucleairs majeures des granulocytes","volume":"49","author":"Morel, P.; Bryon, P.A.; Guyon, J.M.","year":"1968","unstructured":"Morel P, Bryon PA, Guyon JM, et al. Hemopathie maligne de type aplastique avec anomalies nucleairs majeures des granulocytes. Sem H6p (Paris) 1968;49:3026-8.","journal-title":"Sem H6p (Paris)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1182\/blood.V35.5.637.637","article-title":"Chromatin clumping in mature leucocytes: an hitherto unrecognized abnormality","volume":"35","author":"Gustke, S.S.; Becker, G.A.; Garancis, J.C.","year":"1970","unstructured":"Gustke SS, Becker GA, Garancis JC, et al. Chromatin clumping in mature leucocytes: an hitherto unrecognized abnormality. 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Am Jf Clin Pathol 1986;85: 176-9.","journal-title":"Am Jf Clin Pathol"},{"key":"ref_9","first-page":"209","article-title":"Abnormal chromatin clumping in leucocytes: a clue to a new subtype of myelodysplastic syndrome","volume":"45","author":"Jaen, A.; Irriguible, D.; Milla, F.","year":"1990","unstructured":"Jaen A, Irriguible D, Milla F, et al. Abnormal chromatin clumping in leucocytes: a clue to a new subtype of myelodysplastic syndrome. Eur Jf Haematol 1990; 45:209-14.","journal-title":"Eur Jf Haematol"},{"key":"ref_10","first-page":"140","article-title":"Chronic myelomoncytic leukemia (CMML) with lymphodenopathy","author":"Bizet, M.; Callat, M.P.; Goasguen, J.","year":"1992","unstructured":"Bizet M, Callat MP, Goasguen J, et al. Chronic myelomoncytic leukemia (CMML) with lymphodenopathy. F. In: Schmalz F, Muffi GJ, eds. Myelodysplastic syndromes. Berlin: Springer Verlag, 1992:140-6."},{"key":"ref_11","first-page":"1246","article-title":"Chronic myelomonocytic leukemia: natural history and prognostic determinants","volume-title":"Mayo Clin Proc 1989; 64","author":"Tefferi, A.; Hoagland, H.C.; Therneau, T.M.","unstructured":"Tefferi A, Hoagland HC, Therneau TM, et al. Chronic myelomonocytic leukemia: natural history and prognostic determinants. Mayo Clin Proc 1989;64:1246-54."},{"key":"ref_12","first-page":"1099","article-title":"Leukaemia (chronic myeloid leukaemia)","volume":"i:","author":"Scott, R.B.","year":"1957","unstructured":"Scott RB. Leukaemia (chronic myeloid leukaemia). Lancet 1957;i: 1099-103.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennett, J.M.; Catovsky, D.; Daniel, M.T.","year":"1982","unstructured":"Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982;51:189-99.","journal-title":"Br J Haematol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0165-4608(82)90034-6","article-title":"Cytogenetics of preleukemia","volume":"5","author":"Nowell, P.C.","year":"1982","unstructured":"Nowell PC. Cytogenetics of preleukemia. 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Blood 1984;63:1318-23.","journal-title":"Blood"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1172\/JCI111199","article-title":"Pancytocytopenia as a a clonal disorder of a multipotent hematopoietic stem cell","volume":"73","author":"Abkowitz, J.L.; Fialkow, P.J.; Niebruge, D.J.","year":"1984","unstructured":"Abkowitz JL, Fialkow PJ, Niebruge DJ, et al. Pancytocytopenia as a a clonal disorder of a multipotent hematopoietic stem cell. J Clin Invest 1984;73:258-61.","journal-title":"J Clin Invest"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1056\/NEJM198702263160902","article-title":"Monosomy 7 in granulocytes and monocytes in myelodysplastic syndrome","volume":"316","author":"Kere, J.; Ruutu, T.; de la Chapelle, A.","year":"1987","unstructured":"Kere J, Ruutu T, de la Chapelle A. Monosomy 7 in granulocytes and monocytes in myelodysplastic syndrome. N Engl J Med 1987;316:499-503.","journal-title":"N Engl J Med"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000206131","article-title":"Acute myeloid leukaemia developing in a patient with longstanding untreated chronic lymphocytic leukaemia","volume":"75","author":"Wallis, J.P.; Joyner, M.V.","year":"1986","unstructured":"Wallis JP, Joyner MV. Acute myeloid leukaemia developing in a patient with longstanding untreated chronic lymphocytic leukaemia. Acta Haematol 1986;75:229-31.","journal-title":"Acta Haematol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ajcp\/84.2.233","article-title":"Acute lymphoblastic leukemia following myelodysplastic syndrome","volume":"84","author":"Inoshita, T.","year":"1985","unstructured":"Inoshita T. Acute lymphoblastic leukemia following myelodysplastic syndrome. Am J Clin Pathol 1985;84:233-7.","journal-title":"Am J Clin Pathol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/jcp.39.7.728","article-title":"Myelodysplastic syndrome coexisting with acute lymphoblastic leukaemia","volume":"39","author":"Stark, A.N.; Scott, C.S.; Bhatt, B.","year":"1986","unstructured":"Stark AN, Scott CS, Bhatt B, et al. Myelodysplastic syndrome coexisting with acute lymphoblastic leukaemia. J Clin Pathol 1986;39:728-30.","journal-title":"J Clin Pathol"},{"issue":"1","key":"ref_22","first-page":"462","article-title":"Co-existing myelodysplastic syndrome and malignant lymphoma with IgA monoclonal gammopathy terminated in acute myeloid leukemia shortly after treatment of malignant lymphoma and prostate cancer","volume":"78","author":"Wajima, T.; Mukhopadhyay, M.","year":"1991","unstructured":"Wajima T, Mukhopadhyay M. 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Immunologic indices in myelodysplastic syndromes. Cancer 1988;61:1075-81.","journal-title":"Cancer"},{"key":"ref_25","first-page":"1006","article-title":"High risk myelodysplastic syndrome coexistent with chronic lymphocytic leukemia for more than 9 years: inhibition of the myeloid clone by the lymphoid clone?","volume":"5","author":"Bastion, Y.; Thomas, X.; Felman, P.","year":"1991","unstructured":"Bastion Y, Thomas X, Felman P, et al. High risk myelodysplastic syndrome coexistent with chronic lymphocytic leukemia for more than 9 years: inhibition of the myeloid clone by the lymphoid clone? Leukemia 1991;5:1006-9.","journal-title":"Leukemia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1136\/jcp.44.4.344","article-title":"Chronic myelomonocytic leukamia associated with T cell receptor \u00a35 gene rearrangement","volume":"44","author":"Provan, A.B.; Majer, R.V.; Smith, A.G.","year":"1991","unstructured":"Provan AB, Majer RV, Smith AG, et al. Chronic myelomonocytic leukamia associated with T cell receptor \u00a35 gene rearrangement. J Clin Pathol 1991;44:344-5.","journal-title":"J Clin Pathol"},{"key":"ref_27","first-page":"3336","article-title":"Differentiation in mature T lymphoid leukemia cells is unstable and reversible to myeloid cells, without the involvement of a common stem cell","volume-title":"I Immunol","volume":"147","author":"Griesinger, F.; Jansen, B.; Kersey, J.H.","year":"1991","unstructured":"Griesinger F, Jansen B, Kersey JH. Differentiation in mature T lymphoid leukemia cells is unstable and reversible to myeloid cells, without the involvement of a common stem cell. I Immunol 1991;147:3336-41."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1989.tb15074.x","article-title":"A chromosomal basis of lymphoid malignancy in man","volume":"185","author":"Boehm, T.; Rabbitts, T.H.","year":"1989","unstructured":"Boehm T, Rabbitts TH. A chromosomal basis of lymphoid malignancy in man. EurJ7 Biochem 1989;185:1-17.","journal-title":"EurJ7 Biochem"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-2141.1989.tb00238.x","article-title":"A case of myelodysplastic syndrome with abnormal chromatin clumping in leucocytes","volume":"73","author":"Varma, N.; Dash, S.; Marwaha, N.","year":"1989","unstructured":"Varma N, Dash S, Marwaha N, et al. A case of myelodysplastic syndrome with abnormal chromatin clumping in leucocytes. Brj Haematol 1989;73:135.","journal-title":"Brj Haematol"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/1097-0142(197808)42:2+<854::AID-CNCR2820420707>3.0.CO;2-W","article-title":"The preleukemic syndrome (hemopoietic dysplasia)","volume":"42","author":"Uinman, J.W.; Bagby, G.C.","year":"1978","unstructured":"Uinman JW, Bagby GC. The preleukemic syndrome (hemopoietic dysplasia). Cancer 1978;42:854-64.","journal-title":"Cancer"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.46.2.177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:56:50Z","timestamp":1765076210000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.46.2.177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1993,2,1]]},"published-print":{"date-parts":[[1993,2]]}},"alternative-id":["10.1136\/jcp.46.2.177"],"URL":"https:\/\/doi.org\/10.1136\/jcp.46.2.177","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1993,2]]}}}