{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:59:20Z","timestamp":1765666760954,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:p>AIMS--To investigate variations in serum lipid peroxide activities in relation to various clinical entities of liver disease. METHODS--Serum lipid peroxides were measured fluorometrically in eight patients with acute hepatitis, six with liver steatofibrosis, five with chronic persistent hepatitis, 15 with chronic active hepatitis, 28 with liver cirrhosis, 22 with hepatocellular carcinoma; 19 patients with extrahepatic disease (six malignant, 13 benign) were used as controls. RESULTS--Higher serum lipid peroxide concentrations were found in patients with acute hepatitis (4.52 (SEM 0.56)) nmol\/ml than in all other groups of patients (p &lt; 0.01). No significant difference was found among the mean values detected in the groups of patients affected by chronic liver disease and extrahepatic diseases. A history of chronic alcohol consumption was not associated with higher lipid peroxide concentrations. A significant correlation (R2 = 0.4538, R = 0.6737, F = 7.617, p = 0.0000) was found between serum lipid peroxides and a set of indices of inflammation (ESR, total leucocyte count, C-reactive protein) and of hepatic function (aspartate aminotransferase (AST) or alkaline phosphatase (ALP) or bilirubin). Of these, bilirubin was the most significant indicator of inflammation. Analysis of covariance showed a significant difference in lipid peroxide values among groups, even when bilirubin was chosen as an independent variable. CONCLUSIONS--Raised serum lipid peroxide concentrations can be found during acute inflammatory liver disease. Acute change in liver function, reflected by high bilirubin concentrations, seems to be more important for intravascular liberation of lipid peroxides than existence of specific aetiological factors or of severe longstanding global liver damage.<\/jats:p>","DOI":"10.1136\/jcp.46.4.364","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"364-367","source":"Crossref","is-referenced-by-count":8,"title":["Intensity of inflammatory damage and serum lipid peroxide concentrations in liver disease."],"prefix":"10.1136","volume":"46","author":[{"given":"C","family":"Fabris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pirisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Panozzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Soardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Toniutto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Hocza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Bartoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,4,1]]},"reference":[{"key":"ref_1","first-page":"381","article-title":"Free radicals in medicine. I. Chemical nature and biologic reactions","volume-title":"Mayo Clint Proc 1988; 63","author":"Southorn, P.A.; Powis, G.","unstructured":"Southorn PA, Powis G. Free radicals in medicine. I. Chemical nature and biologic reactions. Mayo Clint Proc 1988;63:381-9."},{"key":"ref_2","first-page":"390","article-title":"Free radicals in medicine","volume-title":"II. Involvement in human disease. Mayo Clin Proc 1988; 63","author":"Southorn, P.A.; Powis, G.","unstructured":"Southorn PA, Powis G. Free radicals in medicine. II. Involvement in human disease. Mayo Clin Proc 1988; 63:390-408."},{"key":"ref_3","first-page":"599","article-title":"Biology of disease. Lipid peroxidation and cellular damage in toxic liver injury","volume":"53","author":"Comporti, M.","year":"1985","unstructured":"Comporti M. Biology of disease. Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest 1985; 53:599-623.","journal-title":"Lab Invest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/jcp.43.5.403","article-title":"Oxygen derived free radicals in patients with chronic pancreatic and other digestive diseases","volume":"43","author":"Basso, D.; Panozzo, M.P.; Fabris, C.","year":"1990","unstructured":"Basso D, Panozzo MP, Fabris C, et al. Oxygen derived free radicals in patients with chronic pancreatic and other digestive diseases. J Clin Pathol 1990;43:403-5.","journal-title":"J Clin Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000293145","article-title":"Serum lipid peroxides in induced and spontaneous abortions","volume":"31","author":"Sane, A.S.; Chokshi, S.A.; Mishra, VV, Barad; DP, Shah; VC, Nagpal; S.","year":"1991","unstructured":"Sane AS, Chokshi SA, Mishra VV, Barad DP, Shah VC, Nagpal S. Serum lipid peroxides in induced and spontaneous abortions. Gynecol Obstet Invest 1991;31:172-5.","journal-title":"Gynecol Obstet Invest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/hrt.65.5.245","article-title":"Oxygen free radicals and congestive heart failure","volume":"65","author":"Belch, I.J.; Bridges, A.B.; Scott, N.; Chopra, M.","year":"1991","unstructured":"Belch IJ, Bridges AB, Scott N, Chopra M. Oxygen free radicals and congestive heart failure. Br Heart J 1991; 65:245-8.","journal-title":"Br Heart J"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0952-3278(91)90038-7","article-title":"Reactive oxygen species, lipid peroxides and essential fatty acids in patients with rheumatoid arthritis and systemic lupus erythematosus","volume":"43","author":"Suryaprabha, P.; Das, U.N.; Ramesh, G.; Kumar, K.V.; Kumar, G.S.","year":"1991","unstructured":"Suryaprabha P, Das UN, Ramesh G, Kumar KV, Kumar GS. Reactive oxygen species, lipid peroxides and essential fatty acids in patients with rheumatoid arthritis and systemic lupus erythematosus. Prostaglandins Leukot Essent Fatty Acids 1991;43:251-5.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1097\/00003246-199109000-00004","article-title":"Differential detection of plasma hydroperoxides in sepsis","volume":"19","author":"Keen, R.R.; Stella, L.; Flanigan, D.P.; Lands, W.E.","year":"1991","unstructured":"Keen RR, Stella L, Flanigan DP, Lands WE. Differential detection of plasma hydroperoxides in sepsis. Crit Care Med 1991;19:1114-9.","journal-title":"Crit Care Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/BF01708408","article-title":"Plasma lipid peroxides and antioxidants in human septic shock","volume":"17","author":"Ogilvie, A.C.; Groeneveld, A.B.; Straub, J.P.; Thijs, L.G.","year":"1991","unstructured":"Ogilvie AC, Groeneveld AB, Straub JP, Thijs LG. Plasma lipid peroxides and antioxidants in human septic shock. Intens Care Med 1991;17:40-4.","journal-title":"Intens Care Med"},{"key":"ref_10","first-page":"61","article-title":"Free radical generation, lipid peroxidation and essential fatty acids in patients with septicemia. Prostaglandins Leukot Essent Fatty Acids","volume":"42","author":"Prabha, P.S.; Das, U.N.; Ramesh, G.; Kumar, K.V.; Kamalakar, V.","year":"1991","unstructured":"Prabha PS, Das UN, Ramesh G, Kumar KV, Kamalakar V. Free radical generation, lipid peroxidation and essential fatty acids in patients with septicemia. Prostaglandins Leukot Essent Fatty Acids 1991;42:61-5."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/hep.1840120503","article-title":"Role of ethanolinducible cytochrome P-450 IIEI in carbon tetrachloride-induced damage to centrilobular hepatocytes from ethanol-treated rats","volume":"12","author":"Lindros, K.O.; Cai, Y.; Penttila, K.E.","year":"1990","unstructured":"Lindros KO, Cai Y, Penttila KE. Role of ethanolinducible cytochrome P-450 IIEI in carbon tetrachloride-induced damage to centrilobular hepatocytes from ethanol-treated rats. Hepatology 1990;12:1092-7.","journal-title":"Hepatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM198812223192505","article-title":"Biochemical and molecular basis of alcoholinduced injury to liver and other tissues","volume":"319","author":"Lieber, C.S.","year":"1988","unstructured":"Lieber CS. Biochemical and molecular basis of alcoholinduced injury to liver and other tissues. N Engl J Med 1988;319: 1639-50.","journal-title":"N Engl J Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0168-8278(91)90846-4","article-title":"Hepatotoxicity of ethanol","volume":"12","author":"Lieber, C.S.; DeCarli, L.M.","year":"1991","unstructured":"Lieber CS, DeCarli LM. Hepatotoxicity of ethanol. J Hepatol 1991;12:394-401.","journal-title":"J Hepatol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0076-6879(84)05042-4","article-title":"Assay for blood plasma or serum","volume":"105","author":"Yagi, K.","year":"1984","unstructured":"Yagi K. Assay for blood plasma or serum. Methods in Enzymology 1984;105:328-31.","journal-title":"Methods in Enzymology"},{"key":"ref_15","article-title":"BMDP statistical software manual","author":"Dixon, W.J.; Brown, M.B.; Engelman, L.; Jennrich, R.I.","year":"1990","unstructured":"Dixon WJ, Brown MB, Engelman L, Jennrich RI. BMDP statistical software manual. Berkeley: University of California Press, 1990."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/BF01299917","article-title":"Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease. Evidence of lipid peroxidation","volume":"28","author":"Shaw, S.; Rubin, K.P.; Lieber, C.S.","year":"1983","unstructured":"Shaw S, Rubin KP, Lieber CS. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease. Evidence of lipid peroxidation. Dig Dis Sci 1983;28:585-9.","journal-title":"Dig Dis Sci"},{"key":"ref_17","first-page":"323","article-title":"The significance of the peroxides increase in the plasma of the patients with liver failure","volume":"28","author":"Olinescu, R.; Alexandrescu, R.; Militaru, M.","year":"1990","unstructured":"Olinescu R, Alexandrescu R, Militaru M. The significance of the peroxides increase in the plasma of the patients with liver failure. Med Intemne 1990;28:323-8.","journal-title":"Med Intemne"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.46.4.364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:35:09Z","timestamp":1758789309000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.46.4.364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1993,4,1]]},"published-print":{"date-parts":[[1993,4]]}},"alternative-id":["10.1136\/jcp.46.4.364"],"URL":"https:\/\/doi.org\/10.1136\/jcp.46.4.364","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}