{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T09:13:18Z","timestamp":1765012398513,"version":"3.46.0"},"reference-count":26,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:p>AIMS--To differentiate the serological profiles of chronic (endocarditis) Q fever from the late follow up of acute cases. METHODS--Twenty patients (10 diagnosed with acute and 10 with endocarditis Q fever) were studied. Those diagnosed with acute infection were followed up from 2.5 to 88 months (mean 35.8 months). Serological variables included indirect immunofluorescence against phase I and II of Coxiella burnetii (IgM, IgG, and IgA), complement fixation and rheumatoid factor (RF). RESULTS--All patients with titres of IgA against phase I, after IgG removal, equal to or above 320 and a complement fixation value equal to or above 128 had endocarditis. No patient with acute Q fever had such a serological profile. CONCLUSIONS--The combination of IgA against phase I and complement fixation values may be sufficient to differentiate the serological profile of chronic (endocarditis) Q fever from the late follow up of acute cases.<\/jats:p>","DOI":"10.1136\/jcp.46.5.411","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"411-414","source":"Crossref","is-referenced-by-count":15,"title":["Serological differentiation between acute (late control) and endocarditis Q fever."],"prefix":"10.1136","volume":"46","author":[{"given":"F","family":"Soriano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M T","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Ponte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,5,1]]},"reference":[{"issue":"60","key":"ref_1","first-page":"359","article-title":"The incidence and significance of phase I complement-fixing antibody in Q fever","volume":"1962","author":"Powell, O.W.; Stallman, N.D.","unstructured":"Powell OW, Stallman ND. The incidence and significance of phase I complement-fixing antibody in Q fever. J Hyg (Cambridge) 1962;60:359-64.","journal-title":"J Hyg (Cambridge)"},{"key":"ref_2","first-page":"547","article-title":"A study of 111 consecutive cases. Med3'Aust","volume":"1","author":"fever, Spelman D.W.Q.","year":"1982","unstructured":"Spelman DW. Q fever. A study of 111 consecutive cases. Med3'Aust 1982;1:547-53."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0163-4453(87)93560-2","article-title":"An outbreak of Q fever affecting postal workers in Oxfordshire","volume":"14","author":"Winner, S.J.; Eglin, R.P.; Moore, V.I.M.; Mayon-White, R.T.","year":"1987","unstructured":"Winner SJ, Eglin RP, Moore VIM, Mayon-White RT. An outbreak of Q fever affecting postal workers in Oxfordshire. J Infection 1987;14:255-61.","journal-title":"J Infection"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/JCM.22.4.484-487.1985","article-title":"Immunoglobulin responses in acute Q fever","volume":"22","year":"1985","unstructured":"Dupuis G, Peter 0, Peacock M, Burgdorfer W, Haller E. Immunoglobulin responses in acute Q fever. J Clin Microbiol 1985;22:484-7.","journal-title":"J Clin Microbiol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/infdis\/148.3.477","article-title":"Detection and persistence of specific IgM antibody to Coxiella burnetii by enzyme-linked immunosorbent assay: a comparison with immunofluorescence and complement fixation tests","volume":"148","author":"Field, P.R.; Hunt, J.G.; Murphy, A.M.","year":"1983","unstructured":"Field PR, Hunt JG, Murphy AM. Detection and persistence of specific IgM antibody to Coxiella burnetii by enzyme-linked immunosorbent assay: a comparison with immunofluorescence and complement fixation tests. i Infect Dis 1983;148:477-87.","journal-title":"i Infect Dis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1128\/IAI.41.3.1089-1098.1983","article-title":"Serological evaluation of Q fever in humans: enhanced phase I titers of immunoglobulins G and A are diagnostic for Q fever endocarditis","volume":"41","author":"Peacock, M.G.; Philip, R.N.; Williams, J.C.; Faulkner, R.S.","year":"1983","unstructured":"Peacock MG, Philip RN, Williams JC, Faulkner RS. Serological evaluation of Q fever in humans: enhanced phase I titers of immunoglobulins G and A are diagnostic for Q fever endocarditis. Infect Immun 1983;41: 1089-98.","journal-title":"Infect Immun"},{"key":"ref_7","first-page":"321","article-title":"The antibody response to antigens of Coxiella burnetii","volume":"206","author":"Fiset, P.; Ormsbee, R.A.","year":"1968","unstructured":"Fiset P, Ormsbee RA. The antibody response to antigens of Coxiella burnetii. Zbl Bakt 1968;206:321-9.","journal-title":"Zbl Bakt"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/IAI.39.2.977-981.1983","article-title":"Immunoglobulin responses to Coxiella burnetii (Q fever): single-serum diagnosis of acute infection, using an immunofluorescence technique","volume":"39","author":"Hunt, J.G.; Field, P.R.; Murphy, A.M.","year":"1983","unstructured":"Hunt JG, Field PR, Murphy AM. Immunoglobulin responses to Coxiella burnetii (Q fever): single-serum diagnosis of acute infection, using an immunofluorescence technique. Infect Immun 1983;39:977-81.","journal-title":"Infect Immun"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"400","DOI":"10.7326\/0003-4819-91-3-400","article-title":"Q fever endocarditis in the United States","volume":"91","author":"Kimbrough, R.C.; Ormsbee, R.A.; Peacock, M.; Rogers, W.R.; Bennetts, R.W.; Raaf, J.; Krause, A.; Gardner, C.","year":"1979","unstructured":"Kimbrough RC, Ormsbee RA, Peacock M, Rogers WR, Bennetts RW, Raaf J, Krause A, Gardner C. Q fever endocarditis in the United States. Ann Intern Med 1979;91:400-2.","journal-title":"Ann Intern Med"},{"key":"ref_10","first-page":"3091","article-title":"IgM globulin response in Q fever (Coxiella burnetii) infections","volume":"12","author":"Murphy, A.M.; Magro, L.","year":"1980","unstructured":"Murphy AM, Magro L. IgM globulin response in Q fever (Coxiella burnetii) infections. Pathology 1980;12: 3091-6.","journal-title":"Pathology"},{"key":"ref_11","first-page":"291","article-title":"Antibody responses in acute and chronic Q fever and in subjects vaccinated against Q fever","volume":"19","author":"Worswick, D.; Marmion, B.","year":"1985","unstructured":"Worswick D, Marmion B. Antibody responses in acute and chronic Q fever and in subjects vaccinated against Q fever. JMed Microbiol 1985;19:291-6.","journal-title":"JMed Microbiol"},{"key":"ref_12","first-page":"193","volume":"45","author":"Turck, W.P.G.; Howitt, G.; Turnberg, L.A.; Fox, H.; Longson, M.; Matthews, M.B.; fever, Gupta R.D.Chronic Q.","year":"1976","unstructured":"Turck WPG, Howitt G, Turnberg LA, Fox H, Longson M, Matthews MB, Gupta RD. Chronic Q fever. Q J Med 1976;45:193-217.","journal-title":"Q J Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/01.CIR.53.4.680","article-title":"Q fever endocarditis in Queensland","volume":"53","author":"Wilson, H.G.; Neilson, G.H.; Galea, E.G.; Stafford, G.; O'Brien, M.F.","year":"1976","unstructured":"Wilson HG, Neilson GH, Galea EG, Stafford G, O'Brien MF. Q fever endocarditis in Queensland. Circulation 1976;53:680-4.","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1749-6632.1990.tb42206.x","article-title":"Chronic Q fever: diagnosis and follow-up","volume":"590","author":"Raoult, D.; Levy, P.Y.; Harle, JR, Etienne; J, Massip; P, Goldstein; F, Micoud; M, Beytout; J, Gallais; H, Remy; G, Capron; J.P.","year":"1990","unstructured":"Raoult D, Levy PY, Harle JR, Etienne J, Massip P, Goldstein F, Micoud M, Beytout J, Gallais H, Remy G, Capron JP. Chronic Q fever: diagnosis and follow-up. Ann N YAcad Sci 1990;590:51-60.","journal-title":"Ann N YAcad Sci"},{"key":"ref_15","first-page":"70","article-title":"Diagnosis of endocarditis in acute Q-fever by immunofluorescence serology","volume":"32","author":"Raoult, D.; Urv6lgyi, J.; Etienne, J.; Roturier, M.; Puel, J.; Chaudet, H.","year":"1988","unstructured":"Raoult D, Urv6lgyi J, Etienne J, Roturier M, Puel J, Chaudet H. Diagnosis of endocarditis in acute Q-fever by immunofluorescence serology. Acta Virol 1988;32: 70-4.","journal-title":"Acta Virol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/clinids\/10.1.198","article-title":"Q fever in Spain: Acute and chronic cases, 1981-1985","volume":"10","author":"Tellez, A.; Sainz, C.; Echeverria, C.; de Carlos, S.; Femandez, M.V.; Leon, P.; Brezina, R.","year":"1988","unstructured":"Tellez A, Sainz C, Echeverria C, de Carlos S, Femandez MV, Leon P, Brezina R. Q fever in Spain: Acute and chronic cases, 1981-1985. Rev Infect Dis 1988;10: 198-202.","journal-title":"Rev Infect Dis"},{"key":"ref_17","first-page":"504","article-title":"Endocarditis and intravascular infections","volume-title":"Principles and practice of infectious diseases","author":"Scheld, W.M.; Sande, M.A.","year":"1985","unstructured":"Scheld WM, Sande MA. Endocarditis and intravascular infections. In: Mandell GL, Douglas Jr. RG, Bennett JE, eds. Principles and practice of infectious diseases. New York: John Wiley & Sons 1985:504-30."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.7326\/0003-4819-108-2-209","article-title":"Q fever endocarditis on porcine bioprosthetic valves","volume":"108","author":"Fernindez-Guerrero, M.L.; Muelas, J.M.; Aguado, J.M.","year":"1988","unstructured":"Fernindez-Guerrero ML, Muelas JM, Aguado JM, et al. Q fever endocarditis on porcine bioprosthetic valves. Ann Intern Med 1988;108:209-13.","journal-title":"Ann Intern Med"},{"key":"ref_19","first-page":"54","article-title":"Complement fixation tests. In: Diagnostic methods in clinical virology","author":"Grist, N.R.; Ross, C.A.C.; Bell, E.J.; Stott, E.J.","year":"1966","unstructured":"Grist NR, Ross CAC, Bell EJ, Stott EJ. Complement fixation tests. In: Diagnostic methods in clinical virology. Oxford: Blackwell Scientific Publications, 1966:54-71."},{"key":"ref_20","first-page":"3","article-title":"General principles underlying laboratory diagnosis of viral infections","volume-title":"Diagnostic procedures for viral, rickettsial and chlamydial infection","author":"Hanker, R.A.","year":"1979","unstructured":"Hanker RA. General principles underlying laboratory diagnosis of viral infections. In: Lennette EH, Schmitd NJ eds. Diagnostic procedures for viral, rickettsial and chlamydial infection. Washington, DC: American Public Health Association, 1979:3-48."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1128\/jcm.3.1.51-61.1976","article-title":"Microimmunofluorescence test for the serological study of Rocky Mountain spotted fever and typhus","volume":"3","author":"Philip, R.N.; Casper, E.A.; Ormsbee, R.A.; Peacock, M.G.; Burgdorfer, W.","year":"1976","unstructured":"Philip RN, Casper EA, Ormsbee RA, Peacock MG, Burgdorfer W. Microimmunofluorescence test for the serological study of Rocky Mountain spotted fever and typhus. J Clin Microbiol 1976;3:51-61.","journal-title":"J Clin Microbiol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0732-8893(85)90009-4","article-title":"Immunofluorescence serology. A tool for prognosis of Q fever","volume":"3","author":"Edlinger, E.","year":"1985","unstructured":"Edlinger E. Immunofluorescence serology. A tool for prognosis of Q fever. Diagnost Microbiol Infect Dis 1985;3:343-5 1.","journal-title":"Diagnost Microbiol Infect Dis"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/infdis\/142.2.250","article-title":"Rheumatoid factor in acute viral infections: interference with determination of IgM, IgG, and IgA antibodies in an enzyme immunoassay","volume":"142","year":"1980","unstructured":"Salonen EM, Vaheri A, Suni J, Wager 0. Rheumatoid factor in acute viral infections: interference with determination of IgM, IgG, and IgA antibodies in an enzyme immunoassay. J Infect Dis 1980;142:250-5.","journal-title":"J Infect Dis"},{"key":"ref_24","first-page":"108","article-title":"Rickettsial endocarditis and IgM globulin","volume":"1","author":"Hobbs, JR, Somerville; RG, McSwiggan; D.A.","year":"1967","unstructured":"Hobbs JR, Somerville RG, McSwiggan DA. Rickettsial endocarditis and IgM globulin. Lancet 1967;i:1 108-9.","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"746","DOI":"10.7326\/0003-4819-68-4-746","article-title":"Rheumatoid factors in subacute bacterial endocarditisbacterium duration of disease or genetic predisposition?","volume":"68","author":"Messner, R.P.; Laxdal, T.; Quie, P.G.; Williams, R.C.","year":"1968","unstructured":"Messner RP, Laxdal T, Quie PG, Williams RC. Rheumatoid factors in subacute bacterial endocarditisbacterium duration of disease or genetic predisposition?. Ann Intern Med 1968;68:746-56.","journal-title":"Ann Intern Med"},{"issue":"5","key":"ref_26","first-page":"126","article-title":"Rheumatoid factors and their disappearance following therapy in patients with subacute bacterial endocarditis","volume":"1962","author":"Williams, R.C.; Kunkel, H.G.","unstructured":"Williams RC, Kunkel HG. Rheumatoid factors and their disappearance following therapy in patients with subacute bacterial endocarditis. Arthritis Rheum 1962;5: 126.","journal-title":"Arthritis Rheum"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.46.5.411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T09:08:19Z","timestamp":1765012099000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.46.5.411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1993,5,1]]},"published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.1136\/jcp.46.5.411"],"URL":"https:\/\/doi.org\/10.1136\/jcp.46.5.411","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1993,5]]}}}