{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:34:21Z","timestamp":1778070861301,"version":"3.51.4"},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:p>AIMS--To examine the advantage of systematic plasma iodine assays in establishing the thyroid function of patients with thyroid disorders. METHODS--Iodine was determined by inductively coupled plasma mass spectrometry (ICPMS) in the plasma of 799 patients consulting for possible thyroid disorders, indicated by FT4 and TSH assays. RESULTS--Plasma iodine was below 40 micrograms\/l in 57 (7%) patients, most of whom had hypothyroidism; 40-80 micrograms\/l in 439 (55%) patients, most of whom had normal thyroid hormone function; 80-250 micrograms\/l in 240 (30%) patients, most of whom had hyperthyroidism; and above 250 micrograms\/l in 63 (8%) patients, almost all of whom had iodine overload caused by iodinated drugs, particularly amiodarone, resulting in euthyroidism (24%), hyperthyroidism (36%), and hypothyroidism (16%). Sixty five (7%) had been treated with amiodarone and 27 (3%) with other iodinated drugs. More than 10% of patients with thyroid disorders therefore had an iodine overload. CONCLUSIONS--The determination of total plasma iodine using the simple, accurate ICPMS technique, should be carried out in patients consulting for thyroid disorders, particularly for the detection of an iodine overload.<\/jats:p>","DOI":"10.1136\/jcp.46.5.453","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"453-455","source":"Crossref","is-referenced-by-count":22,"title":["Use of plasma iodine assay for diagnosing thyroid disorders."],"prefix":"10.1136","volume":"46","author":[{"given":"P","family":"Allain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Berre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Krari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lain\u00e9-Cessac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Le Bouil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Barbot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Rohmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Bigorgne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1039\/AN9901500813","article-title":"Determination of iodine and bromine in plasma and urine by inductively coupled plasma mass spectrometry","volume":"115","author":"Allain, P.; Mauras, Y.; Douge, C.; Jaunault, L.; Delaporte, T.; Beaugrand, C.","year":"1990","unstructured":"Allain P, Mauras Y, Douge C, Jaunault L, Delaporte T, Beaugrand C. 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