{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:18:36Z","timestamp":1758845916443,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:p>AIMS--To report the clinical features and pathology of four childhood cases of primary mediastinal non-Hodgkin's lymphoma of non-lymphoblastic pathology. METHODS--Biopsy material was fixed in formol-saline and routinely processed and stained. Immunohistochemical staining was performed on paraffin wax embedded sections using the alkaline phosphatase anti-alkaline phosphatase method. RESULTS--The four patients presented with a large mediastinal mass and symptoms consistent with superior vena cava syndrome secondary to lymphoma. None of the patients had any clinically important disease outside the mediastinum. The four tumours had a histological appearance similar to diffuse large cell non-Hodgkin's lymphoma with sclerosis. Immunohistochemical staining showed that these tumours were of B cell origin. One patient died from infection during treatment and two patients died with progressive disease. The remaining patient remained well 43 months off all treatment. CONCLUSIONS--These four cases further illustrate the heterogeneity of paediatric large cell lymphomas. Clinically, they seem to be equivalent to the B cell lymphoma of the mediastinum, sclerosing type, that is seen in young (predominantly female) adults. The clinical and biological features of this type of tumour in childhood are largely unknown. Using standard treatment protocols, this tumour seems to have a poor prognosis and its optimal treatment therefore requires further clarification.<\/jats:p>","DOI":"10.1136\/jcp.46.6.513","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"513-516","source":"Crossref","is-referenced-by-count":10,"title":["Childhood B cell lymphomas arising in the mediastinum."],"prefix":"10.1136","volume":"46","author":[{"given":"T F","family":"Carr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Lockwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P H","family":"Morris-Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P E","family":"DaCosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Kelsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/1097-0142(19810215)47:4<748::AID-CNCR2820470420>3.0.CO;2-8","article-title":"Diffuse histiocytic lymphoma with sclerosis: A clinicopathologic entity frequently causing superior venacaval obstruction","volume":"47","author":"Miller, J.B.; Variakojis, D.; Bitran, J.D.","year":"1981","unstructured":"Miller JB, Variakojis D, Bitran JD, et al. Diffuse histiocytic lymphoma with sclerosis: A clinicopathologic entity frequently causing superior venacaval obstruction. Cancer 1981;47:748-56.","journal-title":"Cancer"},{"key":"ref_2","first-page":"\"277","article-title":"Diffuse large cell and undifferentiated lymphomas with prominent mediastinal involvement. A poor prognostic subset of patients","volume":"50","author":"Trump, D.L.; Mann, R.B.","year":"1982","unstructured":"Trump DL, Mann RB. Diffuse large cell and undifferentiated lymphomas with prominent mediastinal involvement. A poor prognostic subset of patients with Levniotnt-LHJo,dgkAiins'esnbleyrmgphAoCm,a. Cancer Harris 1982;50:277-82. NL, Linggood RM, Poppema MD. Primary non-Hodgkin's lymphoma of the mediastinum. 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Mediastinal diffuse large cell lymphomas with sclerosis: A clinicopathological study of 60 cases. Am J Surg Pathol 1986;10: 176-91.","journal-title":"Am J Surg Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00705408","article-title":"Primary mediastinal clear cell lymphoma of B-cell type","volume":"409","author":"Moller, P.; Lammler, B.; Eberlein-Gonska, M.; etal","year":"1986","unstructured":"Moller P, Lammler B, Eberlein-Gonska M, etal. Primary mediastinal clear cell lymphoma of B-cell type. Virchows Arch (PatholAnat) 1986;409:79-92.","journal-title":"Virchows Arch (PatholAnat)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/adc.62.1.12","article-title":"Intensive consolidation chemotherapy for acute lymphoblastic leukeamia (UKALL X pilot study)","volume":"62","author":"Pinkerton, C.R.; Bowman, A.; Holtzel, H.; Chessells, J.M.","year":"1987","unstructured":"Pinkerton CR, Bowman A, Holtzel H, Chessells JM. Intensive consolidation chemotherapy for acute lymphoblastic leukeamia (UKALL X pilot study). Arch Dis Child 1987;62:12-8.","journal-title":"Arch Dis Child"},{"key":"ref_7","first-page":"1636","article-title":"The histogenesis of the Reed-Stemnberg cell and its mononuclear counterparts","volume":"49","author":"Jones, D.B.","year":"1987","unstructured":"Jones DB. The histogenesis of the Reed-Stemnberg cell and its mononuclear counterparts. J Pathol 1987;151: 19 Re1eH91J-,5.LeonLeA, Crowley JP. Sclerosis in diffuse histiocytic lymphoma: a clinicopathologic study of 25 cases Cancer 1982;49:1636-48.","journal-title":"J Pathol; Re1eH91J-,5. LeonLeA, Crowley JP. Sclerosis in diffuse histiocytic lymphoma: a clinicopathologic study of 25 cases Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1200\/JCO.1986.4.2.154","article-title":"et at. Mediastinal nonlymphoblastic lymphoma in children: A clinicopathologic Isaacson study","volume":"4","author":"Bunin, N.J.; Hvizdala, E.; Link, M.","year":"1986","unstructured":"Bunin NJ, Hvizdala E, Link M, et at. Mediastinal nonlymphoblastic lymphoma in children: A clinicopathologic Isaacson study. 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