{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:23:32Z","timestamp":1789154612902,"version":"build-2803163510"},"reference-count":7,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>AIMS--To assess the rate at which premortem hypoxia occurs in sudden infant death syndrome (SIDS) when compared with death in early childhood. METHODS--The hypoxanthine concentration was measured as a marker of premortem hypoxia in vitreous humour and cerebrospinal fluid samples obtained at necropsy from 119 children whose ages ranged from 1 week to 2 years. RESULTS--Increasing interval between death and necropsy was accompanied by an increase in the hypoxanthine concentration of vitreous humour for the first 24 hours, at a rate of 8.3 mumol\/l\/hour. Thereafter, there was little change with time, and the results wer corrected to 24 hours according to a regression equation. Cerebrospinal fluid concentrations showed no significant change with time following death. Patients were divided into three groups according to the cause of death: SIDS, cardiac or pulmonary disease, and others. Median values for the cerebrospinal fluid hypoxanthine concentrations were not significantly different among the groups and no difference could be shown between the vitreous humour hypoxanthine concentration in cases of SIDS and those children dying from other causes. Patients with established cardiac or pulmonary disease had a significantly reduced vitreous humour hypoxanthine concentration which may have reflected the premortem use of artificial ventilation. CONCLUSIONS--The results of this study do not support the view that pre-mortem hypoxia is a common feature in SIDS when compared with other causes of death.<\/jats:p>","DOI":"10.1136\/jcp.46.7.650","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"650-653","source":"Crossref","is-referenced-by-count":14,"title":["Vitreous humour and cerebrospinal fluid hypoxanthine concentration as a marker of pre-mortem hypoxia in SIDS."],"prefix":"10.1136","volume":"46","author":[{"given":"K H","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Bonham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Worthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Variend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1993,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0379-0738(78)90031-2","article-title":"Post-mortem hypoxanthine levels in the vitreous humour. An introductory report","volume":"12","author":"Saugstad, O.D.; Olaisen, B.","year":"1978","unstructured":"Saugstad OD, Olaisen B. Post-mortem hypoxanthine levels in the vitreous humour. An introductory report. Forensic Sci Int 1978;12:33-6.","journal-title":"Forensic Sci Int"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1542\/peds.82.4.615","article-title":"Elevated levels of hypoxanthine in vitreous humour indicate prolonged cerebral hypoxia in victims of sudden infant death","volume":"82","author":"Rognum, T.O.; Saugstad, O.D.; Oyasaeter, S.; Olaisen, B.","year":"1988","unstructured":"Rognum TO, Saugstad OD, Oyasaeter S, Olaisen B. Elevated levels of hypoxanthine in vitreous humour indicate prolonged cerebral hypoxia in victims of sudden infant death. Pediatrics 1988;82:615-7.","journal-title":"Pediatrics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1203\/00006450-198912000-00025","article-title":"Postmortem time and storage temperature affect the concentrations of hypoxanthine, other purines, pyrimidines, and nucleosides in avian and porcine vitreous humour","volume":"26","author":"Gardiner, E.E.; Newberry, R.C.; Keng, J.Y.","year":"1989","unstructured":"Gardiner EE, Newberry RC, Keng JY. Postmortem time and storage temperature affect the concentrations of hypoxanthine, other purines, pyrimidines, and nucleosides in avian and porcine vitreous humour. Pediatr Res 1989;26:639-42.","journal-title":"Pediatr Res"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1203\/00006450-199011000-00013","article-title":"Changes in oxypurine concentrations in vitreous humour of pigs during hypoxaemia and post-mortem","volume":"28","author":"Poulsen, J.P.; Rognum, T.O.; Oyasaeter, S.; Saugstad, O.D.","year":"1990","unstructured":"Poulsen JP, Rognum TO, Oyasaeter S, Saugstad OD. Changes in oxypurine concentrations in vitreous humour of pigs during hypoxaemia and post-mortem. Pediatr Res 1990;28:482-4.","journal-title":"Pediatr Res"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000242852","article-title":"Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only","volume":"54","author":"Lun, A.; Gross, J.; Siggel, H.; Pohle, R.","year":"1988","unstructured":"Lun A, Gross J, Siggel H, Pohle R. Concentration of hypoxanthine in both cerebrospinal fluid and brain tissue increases under intensive hypoxia only. Biol Neonate 1988;54: 195-202.","journal-title":"Biol Neonate"},{"key":"ref_6","first-page":"109","article-title":"Use of biological fluids for the rapid diagnosis of potentially lethal disorders of human purine and pyrimidine metabolism","volume":"3","author":"Morris, G.S.; Simmonds, H.A.; Davies, P.M.","year":"1986","unstructured":"Morris GS, Simmonds HA, Davies PM. Use of biological fluids for the rapid diagnosis of potentially lethal disorders of human purine and pyrimidine metabolism. Biomed Chromatogr 1986;3:109-18.","journal-title":"Biomed Chromatogr"},{"issue":"548","key":"ref_7","first-page":"87","article-title":"Xanthine oxidase: biochemistry, distribution and physiology","volume":"1986","author":"Parks, D.A.; Granger, D.N.","unstructured":"Parks DA, Granger DN. Xanthine oxidase: biochemistry, distribution and physiology. Acta Physiol Scand (Suppl) 1986;548:87-99.","journal-title":"Acta Physiol Scand (Suppl)"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.46.7.650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:52:31Z","timestamp":1765691551000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.46.7.650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":7,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1993,7,1]]},"published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1136\/jcp.46.7.650"],"URL":"https:\/\/doi.org\/10.1136\/jcp.46.7.650","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}