{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:44:02Z","timestamp":1765082642175,"version":"3.46.0"},"reference-count":9,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>A 51 year old man with Waldenstr\u00f6m's macroglobulinaemia presented with a malabsorptive syndrome related to extensive small bowel lymphangiectasia caused by immunoglobulin accumulation. The patient's plasma had strong lupus anticoagulant activity and the IgM lambda paraprotein displayed specificity for the negatively charged phospholipids phosphatidyl serine and phosphatidyl inositol, as well as the neutral phosphatidic acid. Despite treatment for the macroglobulinaemia the patient died and at necropsy was found to have myocardial ischaemia and segmental infarcts in the spleen and kidney. The coexistence of these relatively rare findings suggests a possible association between Waldenstr\u00f6m's macroglobulinaemia with gastrointestinal manifestations and paraprotein specificity for phospholipid.<\/jats:p>","DOI":"10.1136\/jcp.46.7.678","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"678-680","source":"Crossref","is-referenced-by-count":13,"title":["Waldenstr\u00f6m's macroglobulinaemia secreting a paraprotein with lupus anticoagulant activity: possible association with gastrointestinal tract disease and malabsorption."],"prefix":"10.1136","volume":"46","author":[{"given":"R C","family":"Tait","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P K","family":"Oogarah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Houghton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S E","family":"Farrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Haeney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,7,1]]},"reference":[{"key":"ref_1","first-page":"621","article-title":"A haemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J7 Clin Invest","volume":"31","author":"Conley, C.L.; Hartmann, R.C.","year":"1952","unstructured":"Conley CL, Hartmann RC. A haemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J7 Clin Invest 1952; 31:621-2."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ajh.2830190308","article-title":"Lupus anticoagulant: an analysis of the clinical and laboratory features of 219 cases","volume":"19","author":"Gastineau, D.A.; Kazmier, F.J.; Nichols, W.L.; Bowie, E.J.W.","year":"1985","unstructured":"Gastineau DA, Kazmier FJ, Nichols WL, Bowie EJW. Lupus anticoagulant: an analysis of the clinical and laboratory features of 219 cases. 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J Clin Pathol 1983;36:30-6.","journal-title":"J Clin Pathol"},{"key":"ref_7","first-page":"308","volume-title":"Intestinal involvement in Waldenstrom's macroglobulinemia. Gastroenterology 1973","volume":"65","author":"Bedine, M.S.; Yardley, J.H.; Elliott, H.L.; Banwell, J.G.; Hendrix, T.R.","unstructured":"Bedine MS, Yardley JH, Elliott HL, Banwell JG, Hendrix TR. Intestinal involvement in Waldenstrom's macroglobulinemia. Gastroenterology 1973;65:308-15."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1182\/blood.V43.4.493.493","article-title":"A monoclonal IgM with antibodylike specifity for phospholipids in a patient with lymphoma","volume":"43","author":"Cooper, M.R.; Cohen, J.H.; Huntley, C.C.; Waite, B.M.; Spees, L.; Spurr, C.L.","year":"1974","unstructured":"Cooper MR, Cohen JH, Huntley CC, Waite BM, Spees L, Spurr CL. A monoclonal IgM with antibodylike specifity for phospholipids in a patient with lymphoma. 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