{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:09:53Z","timestamp":1765886993751,"version":"3.48.0"},"reference-count":17,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:p>AIMS--To determine the gastric distribution of Helicobacter pylori in patients with duodenal and gastric ulcers; and to examine the mucosal inflammatory response. METHODS--Patients with newly diagnosed, uncomplicated duodenal and gastric ulcers were endoscoped and two biopsy specimens each taken from the antrum and the body. Specimens were evaluated blind by one pathologist to determine H pylori activity (scored 0-3) and inflammatory changes (according to the Sydney classification). RESULTS--Adequate biopsy material was obtained from 40 and 44 patients with gastric and duodenal ulcers, respectively. Although antral colonisation with H pylori was more common in the antrum of the latter, the organism was equally likely to be found in the body of both sets of patients; the density of colonisation was higher in those with gastric ulcers. Active gastritis and mucosal atrophy were more common in the body of those with gastric ulcers; intestinal metaplasia was also more common in the antrum of these patients. CONCLUSIONS--Gastritis in patients with duodenal ulcers is mainly antral, but the incidence of gastric body colonisation with H pylori seems to be the same in patients with either type of ulcer. There is, however, a significant difference in colonisation density. The cause and importance of this are not obvious and may be related to either host or organism factors.<\/jats:p>","DOI":"10.1136\/jcp.46.8.754","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"754-756","source":"Crossref","is-referenced-by-count":42,"title":["Distribution of Helicobacter pylori colonisation and associated gastric inflammatory changes: difference between patients with duodenal and gastric ulcers."],"prefix":"10.1136","volume":"46","author":[{"given":"J A","family":"Louw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Falck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"van Rensburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Zak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I N","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/gut.33.3.289","article-title":"Helicobacter pylori and peptic ulcers: the present position","volume":"33","author":"Moss, S.; Calam, J.","year":"1992","unstructured":"Moss S, Calam J. Helicobacter pylori and peptic ulcers: the present position. Gut 1992;33:289-92.","journal-title":"Gut"},{"key":"ref_2","first-page":"28","article-title":"the most common bacterial infection in Africa: a random serological survey","volume":"87","author":"Holcombe, C.; Omotara, B.A.; Eldridge, J.; pylori, Jones D.M.H.","year":"1992","unstructured":"Holcombe C, Omotara BA, Eldridge J, Jones DM. H pylori, the most common bacterial infection in Africa: a random serological survey. Am J Gastroenterol 1992;87: 28-30.","journal-title":"Am J Gastroenterol"},{"key":"ref_3","first-page":"238","article-title":"Gastric glycerolipid as a receptor for Campylobacter pylori","volume":"ii:","author":"Lingwood, C.A.; Pellizzari, A.; Law, H.; Sherman, P.; Drumm, B.","year":"1989","unstructured":"Lingwood CA, Pellizzari A, Law H, Sherman P, Drumm B. Gastric glycerolipid as a receptor for Campylobacter pylori. Lancet 1989;ii:238-41.","journal-title":"Lancet"},{"key":"ref_4","first-page":"2896","article-title":"N-acetylneuraminallactose-binding fibrillar hemagglutinin of Campylobacter pylori: a putative colonization factor antigen","volume":"56","author":"Evans, D.G.; Evans, D.J.; Moulds, J.J.; Graham, D.Y.","year":"1989","unstructured":"Evans DG, Evans DJ, Moulds JJ, Graham DY. N-acetylneuraminallactose-binding fibrillar hemagglutinin of Campylobacter pylori: a putative colonization factor antigen. Infect Immun 1989;56:2896-906.","journal-title":"Infect Immun"},{"key":"ref_5","first-page":"167","article-title":"Campylobacter pylori and duodenal ulcers: the gastrin link","volume":"1","author":"Levi, S.; Haddad, G.; Ghosh, P.; Beardshall, K.; Playford, R.; Calam, J.","year":"1989","unstructured":"Levi S, Haddad G, Ghosh P, Beardshall K, Playford R, Calam J. Campylobacter pylori and duodenal ulcers: the gastrin link. Lancet 1989;i: 1 167-8.","journal-title":"Lancet"},{"key":"ref_6","first-page":"1","article-title":"The Sydney system: a new classification of gastritis. In: Working Party Reports of the World Congresses of Gastroenterology","author":"Misiewiecz, J.I.; Tytgat, G.N.J.; Goodwin, C.S.","year":"1990","unstructured":"Misiewiecz JI, Tytgat GNJ, Goodwin CS, et al. The Sydney system: a new classification of gastritis. In: Working Party Reports of the World Congresses of Gastroenterology, 26-31 August 1990, Sydney, Australia. Oxford: Blackwell Scientific Publications, 1990: 1-10."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/gut.8.5.497","article-title":"The antrum in patients with duodenal and gastric ulcers","volume":"8","author":"Schrager, J.; Spink, R.; Mitra, S.","year":"1967","unstructured":"Schrager J, Spink R, Mitra S. The antrum in patients with duodenal and gastric ulcers. Gut 1967;8:497-508.","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/gut.12.8.639","article-title":"Gastric ulcer and gastritis","volume":"12","author":"Gear, M.W.L.; Truelove, S.C.; Whitehead, R.","year":"1971","unstructured":"Gear MWL, Truelove SC, Whitehead R. Gastric ulcer and gastritis. Gut 1971;12:639-45.","journal-title":"Gut"},{"key":"ref_9","first-page":"825","article-title":"Morphology of chronic antral gastritis: relationship to age, Helicobacter pylori status and peptic ulceration","volume":"4","author":"Sobala, G.M.; Axon, A.T.R.; Dixon, M.F.","year":"1992","unstructured":"Sobala GM, Axon ATR, Dixon MF. Morphology of chronic antral gastritis: relationship to age, Helicobacter pylori status and peptic ulceration. Eur J Gastroenterol Hepatol 1992;4:825-9.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref_10","first-page":"1575","article-title":"Difference in expression of Helicobacter pylori gastritis","volume-title":"antrum and body. Gastroenterology 1992; 102","author":"Bayerdorffer, E.; Lehn, N.; Hatz, R.; Mannes, G.A.; Sauerbruch, T.; Stolte, M.","unstructured":"Bayerdorffer E, Lehn N, Hatz R, Mannes GA, Sauerbruch T, Stolte M. Difference in expression of Helicobacter pylori gastritis in antrum and body. Gastroenterology 1992;102: 1575-82."},{"key":"ref_11","first-page":"135","article-title":"Histological evidence of disease activity in Helicobacter pylori gastritis depends on the depth of mucosal invasion","volume":"102","author":"Neri, M.; Susi, D.; Bovani, I.; Cuccurullo, F.","year":"1992","unstructured":"Neri M, Susi D, Bovani I, Cuccurullo F. Histological evidence of disease activity in Helicobacter pylori gastritis depends on the depth of mucosal invasion. Gastroenterology 1992;102:A135.","journal-title":"Gastroenterology"},{"key":"ref_12","first-page":"424","article-title":"Increased density of Helicobacter pylori on antral biopsy is associated with severity of acute and chronic inflammation and likelihood of duodenal ulceration","volume":"87","author":"Alam, K.; Schubert, T.T.; Bologna, S.D.; Ma, C.K.","year":"1992","unstructured":"Alam K, Schubert TT, Bologna SD, Ma CK. Increased density of Helicobacter pylori on antral biopsy is associated with severity of acute and chronic inflammation and likelihood of duodenal ulceration. Am I Gastroenterol 1992;87:424-8.","journal-title":"Am I Gastroenterol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/00365521.1984.12005739","article-title":"Progression of antral and body gastritis in patients with active and healed duodenal ulcer and duodenitis","volume":"19","author":"Kekki, M.; Sipponen, P.; Siurala, M.","year":"1984","unstructured":"Kekki M, Sipponen P, Siurala M. Progression of antral and body gastritis in patients with active and healed duodenal ulcer and duodenitis. Scand J Gastroenterol 1984;19:382-8.","journal-title":"Scand J Gastroenterol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01347902","article-title":"Location of peptic ulcers in relation to antral and fundal gastritis by chromoendoscopic follow-up examinations","volume":"31","author":"Tatsuta, M.; Iishi, H.; Okuda, S.","year":"1986","unstructured":"Tatsuta M, Iishi H, Okuda S. Location of peptic ulcers in relation to antral and fundal gastritis by chromoendoscopic follow-up examinations. Dig Dis Sci 1986;31: 7-11.","journal-title":"Dig Dis Sci"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0140-6736(91)90477-7","article-title":"Mucosal IGA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration and gastric pathology","volume":"338","author":"Crabtree, J.E.; Taylor, J.D.; Wyatt, J.L.","year":"1991","unstructured":"Crabtree JE, Taylor JD, Wyatt JL, et al. Mucosal IGA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration and gastric pathology. Lancet 1991; 338:332-5.","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0016-5085(89)80057-5","article-title":"Campylobacter pylori and duodenal ulcer disease","volume":"96","author":"Graham, D.Y.","year":"1989","unstructured":"Graham DY. Campylobacter pylori and duodenal ulcer disease. Gastroenterology 1989;96:615-25.","journal-title":"Gastroenterology"},{"key":"ref_17","first-page":"584","article-title":"Chronological transition of the fundic-pyloric border determined by stepwise biopsies of the lesser and greater curvatures","volume-title":"of the stomach. Gastroenterology 1972; 63","author":"Kimura, K.","unstructured":"Kimura K. Chronological transition of the fundic-pyloric border determined by stepwise biopsies of the lesser and greater curvatures of the stomach. Gastroenterology 1972; 63:584-92."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.46.8.754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:21:38Z","timestamp":1765596098000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.46.8.754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":17,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1993,8,1]]},"published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1136\/jcp.46.8.754"],"URL":"https:\/\/doi.org\/10.1136\/jcp.46.8.754","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1993,8]]}}}