{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:49:05Z","timestamp":1765727345013,"version":"3.48.0"},"reference-count":10,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:p>Rearrangements of oncogenes c-myc and c-abl were detected by non-radioactive hybridisation in a case of Burkitt's lymphoma\/leukaemia. The surface phenotype of Burkitt's cells were positive for CD19, CD20, HLA-DR, CD14, CD33 and surface immunoglobulin markers. Although cytogenetic analysis was not performed, the c-myc and heavy immunoglobulin genes had the same 14.2 kilobase EcoRI molecular size fragment, suggesting a possible t(8;14) translocation which is a common marker of this malignancy. The c-abl oncogene was also rearranged in DNA digested BamHI and EcoRI. The physiopathological implications of the rearranged c-abl gene are unknown, this being the first case, as for as is known, of Burkitt's lymphoma\/leukaemia with a rearranged c-abl gene.<\/jats:p>","DOI":"10.1136\/jcp.46.8.778","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"778-779","source":"Crossref","is-referenced-by-count":4,"title":["Rearrangements of c-myc and c-abl genes in tumour cells in Burkitt's lymphoma."],"prefix":"10.1136","volume":"46","author":[{"given":"S","family":"Casares","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Parrado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,8,1]]},"reference":[{"issue":"25","key":"ref_1","first-page":"85","article-title":"Chromosome studies on normal and leukemic human leukocytes","volume":"1960","author":"Nowell, P.; Hungerford, D.J.","unstructured":"Nowell P, Hungerford DJ. Chromosome studies on normal and leukemic human leukocytes. JNCI 1960; 25:85-90.","journal-title":"JNCI"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0092-8674(84)90077-1","article-title":"Philadelphia chromosomal breakpoints are clustered within a limited region bcr on chromosome 22","volume":"36","author":"Groffen, J.; Stephenson, JR, Heisterkamp; N, de Klein; A, Bartram; CR, Grosveld; G.","year":"1984","unstructured":"Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region bcr on chromosome 22. Cell 1984;36:93-9.","journal-title":"Cell"},{"key":"ref_3","first-page":"7476","article-title":"Activation of the c-myc gene by translocation: A model","volume-title":"for translational control. Proc Nadl Acad Sci","volume":"80","author":"Saito, H.; Hayday, A.C.; Wiman, K.; Hayward, W.S.; Tonegawa, S.","year":"1983","unstructured":"Saito H, Hayday AC, Wiman K, Hayward WS, Tonegawa S. Activation of the c-myc gene by translocation: A model for translational control. Proc Nadl Acad Sci USA 1983;80:7476-80."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0003-2697(83)90418-9","article-title":"A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity","volume":"132","author":"Feinberg, A.P.; Vogelstein, B.","year":"1983","unstructured":"Feinberg AP, Vogelstein B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Ann Biochem 1983;132:6-1 1.","journal-title":"Ann Biochem"},{"key":"ref_5","first-page":"431","article-title":"Pre-B cell leukemia with t(8; 14) and a t(14; 18) translocation is preceded by follicular lymphoma","volume":"2","author":"Gauwerky, C.E.; Hoxie, P.C.; Nowell, C.; Croce, C.M.","year":"1988","unstructured":"Gauwerky CE, Hoxie PC, Nowell C, Croce CM. Pre-B cell leukemia with t(8;14) and a t(14; 18) translocation is preceded by follicular lymphoma. Oncogene 1988;2: 431-5.","journal-title":"Oncogene"},{"key":"ref_6","first-page":"8867","article-title":"Activation of MYC in a masked t(8; 17) translocation results in an","volume-title":"aggresive B-cell leukemia. Proc Natl Acad Sci","volume":"86","author":"Gauwerky, C.E.; Huebner, K.; Isobe, M.; Nowell, P.C.; Croce, C.M.","year":"1989","unstructured":"Gauwerky CE, Huebner K, Isobe M, Nowell PC, Croce CM. Activation of MYC in a masked t(8;17) translocation results in an aggresive B-cell leukemia. Proc Natl Acad Sci USA 1989;86:8867-71."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1056\/NEJM198805263182106","article-title":"Activation of the c-myc oncogene in a precursor B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma","volume":"318","author":"de Jong D; BM, Voetdijk; GC, Beverstock; van Ommen GJ; R, Willemze; PM, Kluin","year":"1988","unstructured":"de Jong D, Voetdijk BM, Beverstock GC, van Ommen GJ, Willemze R, Kluin PM. Activation of the c-myc oncogene in a precursor B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma. N Engl JMed 1988;318:1373-8.","journal-title":"N Engl JMed"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1172\/JCI114320","article-title":"Sequential bcl-2 and cmyc oncogene rearrangements associated with clinical transformation of non-Hodgkin's lymphoma","volume":"84","author":"Lee, T.; Innes, D.J.; Williams, M.E.","year":"1989","unstructured":"Lee T, Innes DJ, Williams ME. Sequential bcl-2 and cmyc oncogene rearrangements associated with clinical transformation of non-Hodgkin's lymphoma. Jf Clin Invest 1989;84: 1454-9.","journal-title":"Jf Clin Invest"},{"issue":"1","key":"ref_9","first-page":"1362","article-title":"Genomic alterations involving the c-myc proto-oncogen locus during the evolution of a case of chronic granulocytic leukaemia","volume":"1","author":"McCarthy, D.M.; Rassool, F.V.; Goldman, J.M.; Graham, S.V.; Birnie, G.D.","year":"1984","unstructured":"McCarthy DM, Rassool FV, Goldman JM, Graham SV, Birnie GD. Genomic alterations involving the c-myc proto-oncogen locus during the evolution of a case of chronic granulocytic leukaemia. Lancet 1984;1 1:1362-5.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0308-2261(18)30012-2","article-title":"Lineage heterogeneity in acute leukemia; Acute mixed lineage leukemia and lineage switch","volume":"15","author":"Stass, S.A.; Mirro, J.","year":"1986","unstructured":"Stass SA, Mirro J. Lineage heterogeneity in acute leukemia; Acute mixed lineage leukemia and lineage switch. Clin Hematol 1986;15:811-15.","journal-title":"Clin Hematol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.46.8.778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:47:21Z","timestamp":1765727241000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.46.8.778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1993,8,1]]},"published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1136\/jcp.46.8.778"],"URL":"https:\/\/doi.org\/10.1136\/jcp.46.8.778","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1993,8]]}}}