{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:27:53Z","timestamp":1764995273226,"version":"3.46.0"},"reference-count":12,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:p>AIMS--To determine whether the routine measurement of lymphocyte transformation responses to mitogenic stimuli provide any information additional to that available from routine T cell CD4 and CD8 analysis in patients with HIV infection. METHODS--The case records of 197 immunologically investigated HIV seropositive patients were reviewed. The influence of disease stage on T lymphocyte subsets and lymphocyte transformation responses (LyTR) to phytohaemagglutinin (PHA) and Pokeweed mitogen was assessed. RESULTS--The median CD3 and CD4 counts and LyTR to PHA and Pokeweed mitogen were highest in patients with persistent generalised lymphadenopathy (PGL) and decreased progressively in the order: asymptomatic patients, those with ARC, those with AIDS. LyTR to PHA was preserved in over 70% of all patients, but the response to Pokeweed mitogen was depressed in 8% of patients with PGL, 34% of asymptomatic patients, 68% of those with ARC and 78% of those with AIDS. Subnormal values of both CD4 + T cells and LyTR to Pokeweed mitogen were more common in patients with ARC and AIDS (68%) than in those who were asymptomatic or had PGL (20%). CONCLUSIONS--CD4 T cell analysis and LyTR to Pokeweed mitogen, but not to PHA, both correlate with disease states in patients with HIV infection.<\/jats:p>","DOI":"10.1136\/jcp.46.9.846","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"846-848","source":"Crossref","is-referenced-by-count":1,"title":["Lymphocyte transformation responses to phytohaemagglutinin and pokeweed mitogen in patients at differing stages of HIV infection: are they worth measuring?"],"prefix":"10.1136","volume":"46","author":[{"given":"A S","family":"Bansal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Moran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Haeney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B K","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1993,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/bmj.295.6593.293","article-title":"Lymphocyte transformation response to pokeweed mitogen as a predictive marker for development of AIDS and AIDS related symptoms in homosexual men with HIV antibodies","volume":"295","author":"Hofinann, B.; Lindhardt, B.O.; Gerstoft, J.","year":"1987","unstructured":"Hofinann B, Lindhardt BO, Gerstoft J, et al. Lymphocyte transformation response to pokeweed mitogen as a predictive marker for development of AIDS and AIDS related symptoms in homosexual men with HIV antibodies. Br MedJ 1987;295:293-6.","journal-title":"Br MedJ"},{"key":"ref_2","first-page":"701","article-title":"Predicting the progression to AIDS","volume":"89","author":"Polis, M.A.; Masur, H.","year":"1990","unstructured":"Polis MA, Masur H. Predicting the progression to AIDS. AmJIMed 1990;89:701-5.","journal-title":"AmJIMed"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.4049\/jimmunol.142.6.1874","article-title":"Relatively preserved phytohaemagglutinin as opposed to decreased pokeweed mitogen responses may be due to possibly preserved responses via CD2\/phytohaemagglutinin pathway","volume":"142","author":"Hofmann, B.; Damgard, J.; Odum, N.","year":"1989","unstructured":"Hofmann B, Damgard J, Odum N, et al. 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