{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:45:29Z","timestamp":1790369129436,"version":"4.1.0"},"reference-count":44,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>AIMS--To investigate the expression of interleukin-8 (IL-8) in Helicobacter pylori infected normal and neoplastic gastroduodenal mucosa, and in established gastric cancer cell lines. METHODS--Immunofluorescence techniques were used to localise IL-8 in cryosections of gastric (n = 25) and duodenal (n = 17) endoscopic biopsy specimens an in resected gastric tumour tissue samples from 16 patients. Two gastric cancer cell lines (Kato 3 and MKN 45) were examined for IL-8 protein expression by immunofluorescence and for the presence of IL-8 mRNA by reverse transcription followed by the polymerase chain reaction (RT-PCR). RESULTS--IL-8 was localised to the epithelium in histologically normal gastric mucosa, with particularly strong expression in the surface cells. IL-8 expression was also a feature of surface epithelium in the duodenal bulb, but was much reduced in the second part of the duodenum. In chronic H pylori-associated gastritis gastritis gastric epithelial IL-8 expression was increased and expression of IL-8 within the lamina propria was evident. By contrast, large areas of IL-8 negative epithelium were observed in the body mucosa of a subject with M\u00e9n\u00e9trier's disease. In gastric carcinoma the tumour cells were positive for IL-8. IL-8 was also detected by immunofluorescence in unstimulated Kato 3 and MKN 45 cells, and constitutive IL-8 gene expression in these cell lines was confirmed by detection of IL-8 mRNA by RT-PCR. CONCLUSIONS--Immunoreactive IL-8, a potent neutrophil chemotactic and activating factor, is present in the epithelium of both normal and inflamed gastric mucosa with increased expression in the latter. There is site dependent variation in epithelial IL-8 expression within the gastroduodenal mucosa. The expression of the pro-inflammatory cytokine IL-8 in gastric carcinoma cells may influence peritumoural cellular infiltrates.<\/jats:p>","DOI":"10.1136\/jcp.47.1.61","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"61-66","source":"Crossref","is-referenced-by-count":282,"title":["Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa."],"prefix":"10.1136","volume":"47","author":[{"given":"J E","family":"Crabtree","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L K","family":"Trejdosiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Peichl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J N","family":"Primrose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I J","family":"Lindley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1084\/jem.167.6.1883","article-title":"Molecular cloning of human monocyte-derived neutrophil chemotactic factor (MDNCF) and induction of MDNCF by interleukin-l and tumour necrosis factor","volume":"167","author":"Matsushima, K.; Morishita, K.; Yoshimura, T.","year":"1988","unstructured":"Matsushima K, Morishita K, Yoshimura T, et al. Molecular cloning of human monocyte-derived neutrophil chemotactic factor (MDNCF) and induction of MDNCF by interleukin-l and tumour necrosis factor. Jf Exp Med 1988;167:1883-93.","journal-title":"Jf Exp Med"},{"key":"ref_2","first-page":"9199","article-title":"Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural","volume-title":"and recombinant neutrophil-activating factor. Proc Natl Acad Sci","volume":"85","author":"Lindley, I.; Aschauer, H.; Seifert, J.M.","year":"1988","unstructured":"Lindley I, Aschauer H, Seifert JM, et al. Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor. Proc Natl Acad Sci USA 1988; 85:9199-203."},{"key":"ref_3","first-page":"2","article-title":"and MCAF: novel inflammatory cytokines inducible by I-1 and TNF","volume":"8","author":"Matsushima, K.; Oppenheimn, J.J.","year":"1989","unstructured":"Matsushima K, Oppenheimn JJ. Interleukin 8 and MCAF: novel inflammatory cytokines inducible by I-1 and TNF. Cytokine 1989;1:2-13.","journal-title":"Interleukin"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.iy.09.040191.003153","article-title":"Properties of the novel proinflammatory supergene intercrine cytokine family","volume":"9","author":"Oppenheim, J.J.; Zachariae, C.O.C.; Mukaiada, N.; Matsushima, K.","year":"1991","unstructured":"Oppenheim JJ, Zachariae COC, Mukaiada N, Matsushima K. Properties of the novel proinflammatory supergene intercrine cytokine family. Ann Rev Immunol 1991;9:617-48.","journal-title":"Ann Rev Immunol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1172\/JCI114265","article-title":"Neutrophil-activating peptide-1\/interleukin 8, a novel cytokine that activates neutrophils","volume":"84","author":"Baggiolini, M.; Walz, A.; Kunkel, S.L.","year":"1989","unstructured":"Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1\/interleukin 8, a novel cytokine that activates neutrophils. Jf Clin Invest 1989;84:1045-9.","journal-title":"Jf Clin Invest"},{"key":"ref_6","first-page":"515","article-title":"Aminoacid sequence characterization of two structurally related neutrophil activating peptides obtained from lesional psoriatic scales","volume":"92","author":"Schroder, J.M.; Young, J.; Gregory, H.; Christophers, E.","year":"1989","unstructured":"Schroder JM, Young J, Gregory H, Christophers E. Aminoacid sequence characterization of two structurally related neutrophil activating peptides obtained from lesional psoriatic scales. Jf Invest Dermatol 1989;92: 515-21.","journal-title":"Jf Invest Dermatol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/cs0820273","article-title":"Enhanced synthesis of neutrophil-activating peptide-1\/interleukin-8 in active ulcerative colitis","volume":"82","author":"Mahida, Y.R.; Ceska, M.; Effenberg, F.; Kurlak, L.; Lindley, I.; Hawkey, C.J.","year":"1992","unstructured":"Mahida YR, Ceska M, Effenberg F, Kurlak L, Lindley I, Hawkey CJ. Enhanced synthesis of neutrophil-activating peptide-1\/interleukin-8 in active ulcerative colitis. Clin Sci 1992;82:273-5.","journal-title":"Clin Sci"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-3083.1991.tb01554.x","article-title":"Presence of NAP\/IL-8 in synovial fluids indicates a possible pathogenic role in rheumatoid arthritis","volume":"34","author":"Peichl, P.; Ceska, M.; Effenberger, F.; Haberhauer, G.; Broell, H.; Lindley, I.J.D.","year":"1991","unstructured":"Peichl P, Ceska M, Effenberger F, Haberhauer G, Broell H, Lindley IJD. Presence of NAP\/IL-8 in synovial fluids indicates a possible pathogenic role in rheumatoid arthritis. ScandJ Immunol 1991;34:333-9.","journal-title":"ScandJ Immunol"},{"key":"ref_9","first-page":"2141","article-title":"biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells","volume":"8","author":"Brennan, F.M.; Zachariae, C.O.C.; Larsen, C.G.","year":"1990","unstructured":"Brennan FM, Zachariae COC, Larsen CG, et al. Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells. EurJ Immunol 1990;20:2141-4.","journal-title":"Detection of interleukin"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1172\/JCI115018","article-title":"Enhanced production of neutrophil-activating peptide-1\/interleukin-8 in rheumatoid arthritis","volume":"87","author":"Seitz, M.; Dewald, B.; Gerber, N.; Baggiolini, M.","year":"1991","unstructured":"Seitz M, Dewald B, Gerber N, Baggiolini M. Enhanced production of neutrophil-activating peptide-1\/interleukin-8 in rheumatoid arthritis. J Clin Invest 1991;87: 463-9.","journal-title":"J Clin Invest"},{"key":"ref_11","first-page":"127","article-title":"Some aspects of NAP-1 pathophysiology; lung damage caused by a blood-borne cytokine","volume-title":"Advances in experimental medicine and biology. Vol 305","author":"Rot, A.","year":"1991","unstructured":"Rot A. Some aspects of NAP-1 pathophysiology; lung damage caused by a blood-borne cytokine. In: Westwick J, Lindley IJD, Kunkel SL, eds. Advances in experimental medicine and biology. Vol 305. New York: Plenum Press, 1991:127-35."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1440-1746.1991.tb01451.x","article-title":"Helicobacter pylon and peptic ulceration: histopathological aspects","volume":"6","author":"Dixon, M.F.","year":"1991","unstructured":"Dixon MF. Helicobacter pylon and peptic ulceration: histopathological aspects. J Gastroenterol Hepatol 1991;6: 125-30.","journal-title":"J Gastroenterol Hepatol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0016-5085(89)80057-5","article-title":"Campylobacter pylon and peptic ulcer disease","volume":"96","author":"Graham, D.Y.","year":"1989","unstructured":"Graham DY. Campylobacter pylon and peptic ulcer disease. Gastroenterology 1989;96:615-25.","journal-title":"Gastroenterology"},{"key":"ref_14","first-page":"462","article-title":"Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process","volume":"259","author":"Wallace, J.L.; Keenan, C.M.; Granger, D.N.","year":"1990","unstructured":"Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am Jf Physiol 1990;259: G462-7.","journal-title":"Am Jf Physiol"},{"key":"ref_15","first-page":"878","article-title":"A monoclonal antibody against the CD18 leucocyte adhesion molecule prevents indomethacin-induced gastric damage","volume-title":"the rabbit. Gastroenterology 1991","volume":"100","author":"Wallace, J.L.; McKnight, G.W.; Arfors, K.E.","unstructured":"Wallace JL, McKnight GW, Arfors KE. A monoclonal antibody against the CD18 leucocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit. Gastroenterology 1991;100:878-83."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198902093200606","article-title":"Tissue destruction by neutrophils","volume":"320","author":"Weiss, S.J.","year":"1989","unstructured":"Weiss SJ. Tissue destruction by neutrophils. N Engl Jf Med 1989;320:365-76.","journal-title":"N Engl Jf Med"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-3083.1993.tb01666.x","article-title":"Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylon infection","volume":"37","author":"Crabtree, J.E.; Peichl, P.; Wyatt, J.I.; Stachl, U.; Lindley, I.J.D.","year":"1993","unstructured":"Crabtree JE, Peichl P, Wyatt JI, Stachl U, Lindley IJD. Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylon infection. Scand Jf Immunol 1993;37: 65-70.","journal-title":"Scand Jf Immunol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1084\/jem.169.6.1895","article-title":"Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells","volume":"169","author":"Suzuli, K.; Miyasaka, H.; Ota, H.","year":"1989","unstructured":"Suzuli K, Miyasaka H, Ota H, et al. Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. Y Exp Med 1989;169: 1895-901.","journal-title":"Y Exp Med"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1126\/science.2781291","article-title":"Identification of monocyte chemotactic activity produced by malignant cells","volume":"245","author":"Graves, D.T.; Jiang, Y.L.; Williamson, M.J.; Valente, A.J.","year":"1989","unstructured":"Graves DT, Jiang YL, Williamson MJ, Valente AJ. Identification of monocyte chemotactic activity produced by malignant cells. Science 1989;245:1490-3.","journal-title":"Science"},{"key":"ref_20","first-page":"365","article-title":"Cytokineinduced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas","volume":"140","author":"Abruzzo, L.V.; Thornton, A.J.; Liebert, M.","year":"1992","unstructured":"Abruzzo LV, Thornton AJ, Liebert M, et al. Cytokineinduced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas. Am J Pathol 1992;140:365-73.","journal-title":"Am J Pathol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1172\/JCI114928","article-title":"Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung","volume":"86","author":"Standiford, T.J.; Kunkel, S.L.; Basha, M.A.","year":"1990","unstructured":"Standiford TJ, Kunkel SL, Basha MA et al. Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. Jf Clin Invest 1990;86: 1945-53.","journal-title":"Jf Clin Invest"},{"key":"ref_22","first-page":"464","article-title":"Neutrophil chemotactic factors produced by a cell line from thyroid carcinoma","volume":"52","author":"Yoshida, M.; Matsuzaki, H.; Sakata, K.","year":"1992","unstructured":"Yoshida M, Matsuzaki H, Sakata K. Neutrophil chemotactic factors produced by a cell line from thyroid carcinoma. Cancer Res 1992;52:464-9.","journal-title":"Cancer Res"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/1523-1747.ep12481934","article-title":"Expression and secretion of chemotactic cytokines by normal human melanocytes and melanoma cells","volume":"97","author":"Zachariae, C.O.; Threstrup-Pedersen, K.; Matsushima, K.","year":"1991","unstructured":"Zachariae CO, Threstrup-Pedersen K, Matsushima K. Expression and secretion of chemotactic cytokines by normal human melanocytes and melanoma cells. J Invest Dermatol 1991;97:593-9.","journal-title":"J Invest Dermatol"},{"key":"ref_24","first-page":"22506","article-title":"Tumour necrosis factor a and interferon T synergistically induce interleukin-8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites","volume":"267","author":"Yasumoto, K.; Okamoto, S.; Mukaida, N.; Murakami, S.; Mai, M.; Matsushima, K.","year":"1992","unstructured":"Yasumoto K, Okamoto S, Mukaida N, Murakami S, Mai M, Matsushima K. Tumour necrosis factor a and interferon T synergistically induce interleukin-8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene. JfBiol Chem 1992;267:22506-11.","journal-title":"of the interleukin 8 gene. JfBiol Chem"},{"key":"ref_25","first-page":"1","article-title":"The Sydney system: a new classification of gastritis. Working Party Reports of the World Congresses of Gastroenterology","author":"Misiewicz, J.J.; Tytgat, G.N.J.; Goodwin, C.S.","year":"1990","unstructured":"Misiewicz JJ, Tytgat GNJ, Goodwin CS, et al. The Sydney system: a new classification of gastritis. Working Party Reports of the World Congresses of Gastroenterology. Oxford: Blackwell Scientific Publications, 1990:1-10."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","article-title":"The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification","volume":"64","author":"Lauren, P.","year":"1965","unstructured":"Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965;64:31-49.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0014-4827(85)90269-1","article-title":"Microheterogenous expression of peanut agglutininbinding sites in the extracellular matrix of cultured cells","volume":"156","author":"Trejdosiewicz, L.K.; Southgate, J.; Hodges, G.M.; Goodman, S.L.","year":"1985","unstructured":"Trejdosiewicz LK, Southgate J, Hodges GM, Goodman SL. Microheterogenous expression of peanut agglutininbinding sites in the extracellular matrix of cultured cells. Exp Cell Res 1985;156:153-63.","journal-title":"Exp Cell Res"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/0014-4827(86)90037-6","article-title":"Phenotypic analysis of cultured melanoma cells: expression of cytokeratin-type intermediate filaments by a human melanoma cell line","volume":"164","author":"Trejdosiewicz, L.K.; Southgate, J.; Kempshead, J.T.; Hodges, G.M.","year":"1986","unstructured":"Trejdosiewicz LK, Southgate J, Kempshead JT, Hodges GM. Phenotypic analysis of cultured melanoma cells: expression of cytokeratin-type intermediate filaments by a human melanoma cell line. Exp Cell Res 1986;164: 388-98.","journal-title":"Exp Cell Res"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/ard.51.1.19","article-title":"Human neutrophil activating peptide\/interleukin 8, acts as an autoantigen in rheumatoid arthritis","volume":"51","author":"Peichl, P.; Ceska, M.; Broell, H.; Effenberger, F.; Lindley, I.J.D.","year":"1992","unstructured":"Peichl P, Ceska M, Broell H, Effenberger F, Lindley IJD. Human neutrophil activating peptide\/interleukin 8, acts as an autoantigen in rheumatoid arthritis. Ann Rheum Dis 1992;51:19-22.","journal-title":"Ann Rheum Dis"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1128\/IAI.57.2.623-629.1989","article-title":"Molecular cloning and expression of Campylobacter pylori species-specific antigens in Escherichia coli K-12","volume":"57","author":"Clayton, C.L.; Wren, B.W.; Mullany, P.; Topping, A.; Tabaqchali, S.","year":"1989","unstructured":"Clayton CL, Wren BW, Mullany P, Topping A, Tabaqchali S. Molecular cloning and expression of Campylobacter pylori species-specific antigens in Escherichia coli K-12. Infect Immun 1989;57:623-9.","journal-title":"Infect Immun"},{"key":"ref_31","first-page":"61","article-title":"Establishment of cultured cell lines derived from a human gastric carcinoma","volume":"48","author":"Sekiguchi, M.; Sakakibara, K.; Fujii, G.","year":"1978","unstructured":"Sekiguchi M, Sakakibara K, Fujii G. Establishment of cultured cell lines derived from a human gastric carcinoma. JpnJIExp Med 1978;48:61-8.","journal-title":"JpnJIExp Med"},{"key":"ref_32","first-page":"737","article-title":"Establishment of cultured cell lines of human stomach cancer origin and their morphological characteristics","volume":"91","author":"Hojo, J.","year":"1977","unstructured":"Hojo J. Establishment of cultured cell lines of human stomach cancer origin and their morphological characteristics. Niigata Igakukai Zasshi 1977;91:737-63.","journal-title":"Niigata Igakukai Zasshi"},{"key":"ref_33","article-title":"Molecular cloning-a laboratory manual","author":"Sambrook, J.; Fritsch, E.F.; Maniatis, T.","year":"1989","unstructured":"Sambrook J, Fritsch EF, Maniatis T. Molecular cloning-a laboratory manual. 2nd Edn. New York: Cold Spring Harbour Laboratory Press, 1989.","edition":"2nd Edn"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/hep.1840140627","article-title":"Kupffer cell-derived cytokines induce the synthesis of a leukocyte chemotactic peptide, interleukin-8, in human hepatoma and primary hepatocyte cultures","volume":"14","author":"Thornton, A.J.; Ham, J.; Kunkel, S.L.","year":"1991","unstructured":"Thornton AJ, Ham J, Kunkel SL. Kupffer cell-derived cytokines induce the synthesis of a leukocyte chemotactic peptide, interleukin-8, in human hepatoma and primary hepatocyte cultures. Hepatology 1991;14:1112-22.","journal-title":"Hepatology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1136\/gut.32.12.1473","article-title":"Mucosal tumour necrosis factor a and interleukin-6 in patients with Helicobacter pylori associated gastritis","volume":"32","author":"Crabtree, J.E.; Shallcross, T.M.; Heatley, R.V.; Wyatt, J.I.","year":"1991","unstructured":"Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. Mucosal tumour necrosis factor a and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 1991;32:1473-7.","journal-title":"Gut"},{"key":"ref_36","first-page":"894","article-title":"Soluble surface proteins from Helicobacter pylori activate monocytes\/macrophages by lipopolysaccharide-independent mechanism. J7 Clin Invest","volume":"87","author":"Mai, U.E.H.; Perez-Perez, G.I.; Wahl, L.M.; Wahl, S.M.; Blaser, M.J.; Smith, P.D.","year":"1991","unstructured":"Mai UEH, Perez-Perez GI, Wahl LM, Wahl SM, Blaser MJ, Smith PD. Soluble surface proteins from Helicobacter pylori activate monocytes\/macrophages by lipopolysaccharide-independent mechanism. J7 Clin Invest 1991;87:894-900."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/BF01307522","article-title":"Neutrophil chemotaxis in gastric mucosa. A signal-to-response comparison","volume":"36","author":"Kozol, B.; Domanowski, A.; Jaszewski, R.","year":"1991","unstructured":"Kozol B, Domanowski A, Jaszewski R, et al. Neutrophil chemotaxis in gastric mucosa. A signal-to-response comparison. Dig Dis Sci 1991;36:1277-80.","journal-title":"Dig Dis Sci"},{"key":"ref_38","first-page":"853","article-title":"Neutrophil activation by Helicobacterpyloni","volume-title":"Gut","volume":"32","author":"Mooney, C.; Keenan, J.; Munster, D.","year":"1991","unstructured":"Mooney C, Keenan J, Munster D, et al. Neutrophil activation by Helicobacterpyloni. Gut 1991;32:853-7."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.175.2.517","article-title":"Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa","volume":"175","author":"Mai, U.E.H.; Perez-Perez, G.I.; Allen, J.B.; Wahl, S.M.; Blaser, M.J.; Smith, P.D.","year":"1992","unstructured":"Mai UEH, Perez-Perez GI, Allen JB, Wahl SM, Blaser MJ, Smith PD. Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa. J Exp Med 1992;175:517-25.","journal-title":"J Exp Med"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1136\/gut.31.11.1242","article-title":"Paf-acether synthesis by Helicobacter pylori","volume":"31","author":"Denizot, Y.; Sobhani, I.; Rambaud, J.C.; Lewin, M.; Thomas, Y.; Benveniste, J.","year":"1990","unstructured":"Denizot Y, Sobhani I, Rambaud JC, Lewin M, Thomas Y, Benveniste J. Paf-acether synthesis by Helicobacter pylori. Gut 1990;31:1242-5.","journal-title":"Gut"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1136\/gut.33.6.738","article-title":"Chemotactic activity of Helicobacter pylon sonicate for human polymorphonuclear leucoytes and monocytes","volume":"33","author":"Nielsen, H.; Andersen, L.P.","year":"1992","unstructured":"Nielsen H, Andersen LP. Chemotactic activity of Helicobacter pylon sonicate for human polymorphonuclear leucoytes and monocytes. Gut 1992;33:738-42.","journal-title":"Gut"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gut.33.8.1020","article-title":"Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils","volume":"33","author":"Craig, P.M.; Territo, M.C.; Karnes, W.E.; Walsh, J.H.","year":"1992","unstructured":"Craig PM, Territo MC, Karnes WE, Walsh JH. Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gut 1992;33:1020-3.","journal-title":"Gut"},{"issue":"4","key":"ref_43","article-title":"Secretion of immunologically and biologically active interleukin-8 by a gastric epithelial cell line","volume":"34","author":"Plusa, S.; Farmery, S.; Peichl, P.; Lindley, I.J.D.; Primrose, J.N.; Crabtree, J.E.","year":"1993","unstructured":"Plusa S, Farmery S, Peichl P, Lindley IJD, Primrose JN, Crabtree JE. Secretion of immunologically and biologically active interleukin-8 by a gastric epithelial cell line. 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