{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:43:52Z","timestamp":1765727032309,"version":"3.48.0"},"reference-count":19,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:p>AIMS--To evaluate the immunoreactivities of neoplastic and non-neoplastic monocytoid B cells (MBC) and compare them with hairy cell leukemia (HCL) and mantle cell lymphoma (MCL). METHODS--An immunohistochemical study of paraffin wax embedded sections was done on surgically resected specimens of spleens with MBC clusters from patients with gastric cancer (14 cases), tonsils (five cases), and lymph node (two cases) showing lymphoid follicular hyperplasia (LFH), submandibular lymph nodes containing MBC in Sj\u00f6gren's syndrome (one case). Extranodal organs affected by MCL (three cases) and monocytoid B cell lymphoma (MBCL) (seven cases), and spleens from HCL (four cases) were also studied. These specimens were fixed in 10% formalin and routinely processed for paraffin wax embedding. Fresh spleen specimens from patients with liver cirrhosis (one case) and gastric cancer (seven cases) were snap frozen. RESULTS--Mantle zone lymphocytes were DBA.44, CD74 positive and showed a weaker reaction for CDw75 than marginal zone lymphocytes and MBC, which were almost DBA negative. In neoplastic diseases tumour cells in MCL were DBA.44, CD74, and CDw75 positive. MBCL showed a positive reaction for CD74 and CDw75, but positivity for DBA.44 was observed in only one of seven cases. The HCL specimens, all positive for DBA.44, showed a weaker reaction for CD74 and a stronger reaction for CDw75 than either MCL and MBCL specimens. CONCLUSION--These results show that mantle zone lymphocytes and MCL more closely matched HCL for reactivity to DBA.44 than MBC and MBCL. Reactivities for DBA.44 and CDw75 were greater in MBCL compared with its non-neoplastic counterpart, MBC.<\/jats:p>","DOI":"10.1136\/jcp.47.10.928","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"928-932","source":"Crossref","is-referenced-by-count":10,"title":["Immunoreactivity of neoplastic and non-neoplastic monocytoid B lymphocytes for DBA.44 and other antibodies."],"prefix":"10.1136","volume":"47","author":[{"given":"M","family":"Ohsawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Machii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Aozasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/ajcp\/81.4.453","article-title":"\"Monocytoid\" cells in reactive follicular hyperplasia with and without multifocal histiocytic reactions: an immunohistochemical study of 21 cases including suspected cases of toxoplasmic lymphadenitis","volume":"81","author":"Sheinbani, K.; Fritz, R.M.; Winberg, C.D.; Burke, J.S.; Rappaport, H.","year":"1984","unstructured":"Sheinbani K, Fritz RM, Winberg CD, Burke JS, Rappaport H. \"Monocytoid\" cells in reactive follicular hyperplasia with and without multifocal histiocytic reactions: an immunohistochemical study of 21 cases including suspected cases of toxoplasmic lymphadenitis. Am J Clin Pathol 1984;81:453-8.","journal-title":"Am J Clin Pathol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0046-8177(85)80274-4","article-title":"Monocytoid B lymphocytes: their relation to the patterns of the acquired immunodeficiency syndrome (AIDS) and AIDS-related lymphadnopathy","volume":"16","author":"Sohn, C.C.; Sheibani, K.; Winberg, C.D.; Rappaport, H.","year":"1985","unstructured":"Sohn CC, Sheibani K, Winberg CD, Rappaport H. Monocytoid B lymphocytes: their relation to the patterns of the acquired immunodeficiency syndrome (AIDS) and AIDS-related lymphadnopathy. Hum Pathol 1985; 16:979-85.","journal-title":"Hum Pathol"},{"key":"ref_3","first-page":"44","article-title":"Immature sinus histiocytosis. Their identification as a novel B-cell population","volume":"117","author":"Stein, H.; Lennert, K.; Mason, D.Y.; Liangru, S.; Ziegler, A.","year":"1984","unstructured":"Stein H, Lennert K, Mason DY, Liangru S, Ziegler A. Immature sinus histiocytosis. Their identification as a novel B-cell population. Am J Pathol 1984;117:44-52.","journal-title":"Am J Pathol"},{"key":"ref_4","first-page":"266","article-title":"Immature sinus histiocytosis. Light and electron microscopic features, immunologic phenotypes and relationship with marginal zone lymphocytes","volume":"118","author":"den Oord JJ, Van; de Wolf-Peeters C; R, De Vos; VJ, Desmet","year":"1985","unstructured":"Van den Oord JJ, de Wolf-Peeters C, De Vos R, Desmet VJ. Immature sinus histiocytosis. Light and electron microscopic features, immunologic phenotypes and relationship with marginal zone lymphocytes. Am Jf Pathol 1985;118:266-77.","journal-title":"Am Jf Pathol"},{"key":"ref_5","first-page":"717","article-title":"The occurrence of monocytoid B-lymphocytes in the spleens of patients with gastric cancer","volume":"6","author":"N.","year":"1993","unstructured":"Aozasa K, Ohsawa M, Horiuchi K, Mishima K, Kawano K, Ito N. The occurrence of monocytoid B-lymphocytes in the spleens of patients with gastric cancer. Mod Pathol 1993;6:717-20.","journal-title":"Mod Pathol"},{"key":"ref_6","first-page":"121","article-title":"The occurrence of monocytoid Blymphocytes in autoimmune disorders","volume":"6","author":"S, Matsuzuka F.","year":"1993","unstructured":"Aozasa K, Ohsawa M, Horiuchi K, Saeki K, Katayama S, Matsuzuka F, et al. The occurrence of monocytoid Blymphocytes in autoimmune disorders. Mod Pathol 1993;6: 121-4.","journal-title":"Mod Pathol"},{"key":"ref_7","first-page":"310","article-title":"Monocytoid B-cell lymphoma: a novel Bcell neoplasm","volume":"124","author":"Sheibani, K.; Sohn, C.C.; Burke, J.S.; Winberg, C.D.; Wu, A.M.; Rappaport, H.","year":"1986","unstructured":"Sheibani K, Sohn CC, Burke JS, Winberg CD, Wu AM, Rappaport H. Monocytoid B-cell lymphoma: a novel Bcell neoplasm. Am Pathol 1986;124:310-18.","journal-title":"Am Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1182\/blood.V59.3.609.609","article-title":"The phenotype of the neoplastic cells of hairy cell leukemia studied with monoclonal antibodies","volume":"59","author":"Jansen, J.; LeBien, T.W.; Kersey, J.H.","year":"1982","unstructured":"Jansen J, LeBien TW, Kersey JH. The phenotype of the neoplastic cells of hairy cell leukemia studied with monoclonal antibodies. Blood 1982;59:609-14.","journal-title":"Blood"},{"key":"ref_9","first-page":"4522","article-title":"Rearrangement and expression of immunoglobulin genes and expression of Tac antigen","volume-title":"hairy cell leukemia. Proc Nad Acad Sci","volume":"80","author":"Korsmeyer, S.J.; Greene, W.C.; Cossman, J.; Hsu, S.-M.; Jensen, J.P.; Neckers, L.M.","year":"1983","unstructured":"Korsmeyer SJ, Greene WC, Cossman J, Hsu S-M, Jensen JP, Neckers LM, et al. Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. Proc Nad Acad Sci USA 1983; 80:4522-6."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1182\/blood.V65.4.974.974","article-title":"The monoclonal antibodies a S-HCLI (a Leu-14) and a S-HCL(a Leu-M5) allow the diagnosis of hairy cell leukemia","volume":"65","author":"Schwarting, R.; Stein, H.; Wang, C.Y.","year":"1985","unstructured":"Schwarting R, Stein H, Wang CY. The monoclonal antibodies a S-HCLI (a Leu-14) and a S-HCL(a Leu-M5) allow the diagnosis of hairy cell leukemia. Blood 1985;65:974-83.","journal-title":"Blood"},{"key":"ref_11","first-page":"298","article-title":"Hairy cells and monocytoid B-lymphocytes: are they related?","volume":"1","author":"Burke, J.S.; Sheibani, K.","year":"1987","unstructured":"Burke JS, Sheibani K. Hairy cells and monocytoid B-lymphocytes: are they related? Leukemia 1987;1:298-300.","journal-title":"Leukemia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0046-8177(92)90239-Y","article-title":"Sheibani K: Antigen phenotypes of hairy cell leukemia and monocytoid B-cell lymphoma: An immunohistochemical evaluation of 66 cases","volume":"23","author":"Stroup, R.M.","year":"1992","unstructured":"Stroup RM, Sheibani K: Antigen phenotypes of hairy cell leukemia and monocytoid B-cell lymphoma: An immunohistochemical evaluation of 66 cases. Hum Pathol 1992;23: 172-7.","journal-title":"Hum Pathol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1182\/blood.V74.7.2476.2476","article-title":"Production of anti-B monoclonal antibodies (DBB.42, DBA.44, DNA.7, and DND.53) reactive on paraffin-embedded tissues with a new B-lymphoma cell line grafted into a thymic nude mice","volume":"74","author":"T, Al Saati; S, Caspar; P, Brousset; S, Chittal; P, Caveriviere; H, Hounieu","year":"1989","unstructured":"Al Saati T, Caspar S, Brousset P, Chittal S, Caveriviere P, Hounieu H, et al. Production of anti-B monoclonal antibodies (DBB.42, DBA.44, DNA.7, and DND.53) reactive on paraffin-embedded tissues with a new B-lymphoma cell line grafted into a thymic nude mice. Blood 1989; 74:2476-85.","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1182\/blood.V73.2.573.573","article-title":"Monocytoid B-cell lymphoma: its evolution and relationship to other low-grade B-cell neoplasms","volume":"73","author":"Traweek, S.T.; Sheibani, K.; Winberg, C.D.; Mena, R.R.; Wu, A.M.; Rappaport, H.","year":"1989","unstructured":"Traweek ST, Sheibani K, Winberg CD, Mena RR, Wu AM, Rappaport H. Monocytoid B-cell lymphoma: its evolution and relationship to other low-grade B-cell neoplasms. Blood 1989;73:573-8.","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/ajcp\/98.1.26","article-title":"Hairy cell leukemia. Diagnosis of bone marrow involvement in paraffin-embedded sections with monoclonal antibody DBA.44","volume":"98","author":"Hounieu, H.; Chittal, S.M.; Al Saati, T.; Mascarel, A.; Sabattini, E.; Pileri, S.","year":"1992","unstructured":"Hounieu H, Chittal SM, Al Saati T, Mascarel A, Sabattini E, Pileri S, et al. Hairy cell leukemia. Diagnosis of bone marrow involvement in paraffin-embedded sections with monoclonal antibody DBA.44. Am 7 Clin Pathol 1992; 98:26-33.","journal-title":"Am 7 Clin Pathol"},{"key":"ref_16","first-page":"123","article-title":"Phenotypic expression of B lymphocytes. III. Marginal zone B cells in the spleen are characterized by the expression of Tac and alkaline phosphatase","volume":"135","author":"Hsu, S.-M.","year":"1985","unstructured":"Hsu S-M. Phenotypic expression of B lymphocytes. III. Marginal zone B cells in the spleen are characterized by the expression of Tac and alkaline phosphatase. J7 Immunol 1985;135:123-30."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00320293","article-title":"Hairy cell leukemia: a B-lymphocytic disorder derived from splenic marginal zone lymphocytes?","volume":"50","author":"den Oord JJ, Van; de Wolf-Peeters C; VJ, Desmet","year":"1985","unstructured":"Van den Oord JJ, de Wolf-Peeters C, Desmet VJ. Hairy cell leukemia: a B-lymphocytic disorder derived from splenic marginal zone lymphocytes? Blut 1985;50:191-4.","journal-title":"Blut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0046-8177(89)90040-3","article-title":"Splenic marginal zone lymphocytes and related cells in the lymph node: A morphologic and immunohistochemical study","volume":"20","author":"JHJM, Van Krieken; C, Von Schilling; PM, Kluin; K, Lennert","year":"1989","unstructured":"Van Krieken JHJM, Von Schilling C, Kluin PM, Lennert K. Splenic marginal zone lymphocytes and related cells in the lymph node: A morphologic and immunohistochemical study. Hum Pathol 1989;20:320-5.","journal-title":"Hum Pathol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/ajcp\/86.4.475","article-title":"The marginal zone in human reactive lymph node","volume":"86","author":"den Oord JJ, Van; C, De Wolf-Peeters; VJ, Desmet","year":"1986","unstructured":"Van den Oord JJ, De Wolf-Peeters C, Desmet VJ. The marginal zone in human reactive lymph node. 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