{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:22:05Z","timestamp":1791930125445,"version":"4.3.4"},"reference-count":14,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p>AIMS--To classify lesions discovered at colectomy in patients with ulcerative colitis; to assess the importance of histological findings by correlating them with biochemical parameters. METHODS--Liver tissue specimens taken at colectomy from 59 patients with chronic ulcerative colitis were studied using light microscopy. The findings were compared with results of biochemical liver function tests. RESULTS--Abnormal laboratory findings were found in 12 patients with liver histology consistent with primary sclerosing cholangitis. Non-specific reactive hepatitis was observed in six patients, eight had fatty liver, and three minor non-specific parenchymal changes. Twenty nine patients had normal liver histology. The highest cholestatic serum enzyme activities were seen in two patients with sclerosing cholangitis. Cholangiography in these patients also revealed changes in the extrahepatic bile ducts. However, identical histological changes were also present in patients with only slightly abnormal or even normal liver enzyme activities. CONCLUSION--Biochemical tests of liver function do not reliably indicate the extent or severity of bile duct damage in ulcerative colitis, the assessment of which requires liver biopsy.<\/jats:p>","DOI":"10.1136\/jcp.47.11.1019","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1019-1021","source":"Crossref","is-referenced-by-count":10,"title":["Liver lesions found at colectomy in ulcerative colitis: correlation between histological findings and biochemical parameters."],"prefix":"10.1136","volume":"47","author":[{"given":"J","family":"Mattila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Aitola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Matikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.7326\/0003-4819-72-4-475","article-title":"Liver disease in ulcerative colitis","volume":"72","author":"Eade, M.N.","year":"1970","unstructured":"Eade MN. Liver disease in ulcerative colitis. Ann Intern Med 1970;72:475-82.","journal-title":"Ann Intern Med"},{"key":"ref_2","first-page":"217","article-title":"Extraintestinal complications","volume-title":"bowel disease","author":"Kern, F.","year":"1980","unstructured":"Kern F. Extraintestinal complications. In: Kirsner JB, Shorter RG, eds. Inflammatory bowel disease, 2nd edn. Philadelphia: Lea and Febiger, 1980:217-27.","edition":"2nd edn"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1056\/NEJM198404053101407","article-title":"Primary sclerosing cholangitis","volume":"310","author":"LaRusso, N.F.; Russel, H.; Ludwig, J.; MacCarty, R.L.","year":"1984","unstructured":"LaRusso NF, Russel H, Ludwig J, MacCarty RL. Primary sclerosing cholangitis. N Engl J Med 1984;310:899-903.","journal-title":"N Engl J Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.7326\/0003-4819-102-5-581","article-title":"Pericholangitis in chronic ulcerative colitis: primary sclerosing cholangitis of the small bile ducts?","volume":"102","author":"Wee, A.; Ludwig, J.","year":"1985","unstructured":"Wee A, Ludwig J. Pericholangitis in chronic ulcerative colitis: primary sclerosing cholangitis of the small bile ducts? Ann Intern Med 1985;102:581-7.","journal-title":"Ann Intern Med"},{"key":"ref_5","first-page":"1","article-title":"Surgical pathology of the syndrome of primary sclerosing cholangitis","volume":"13","author":"Ludwig, J.","year":"1989","unstructured":"Ludwig J. Surgical pathology of the syndrome of primary sclerosing cholangitis. Am J Surg Pathol 1989;13(Suppl 1):43-9.","journal-title":"Am J Surg Pathol"},{"key":"ref_6","first-page":"193","article-title":"Primary sclerosing cholangitis","author":"Ludwig, J.; LaRusso, F.; Wiesner, R.H.","year":"1986","unstructured":"Ludwig J, LaRusso F, Wiesner RH. Primary sclerosing cholangitis. In: Peters LR, Craig R, eds. Liver pathology. New York: Churchill Livingstone, 1986:193-213."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/oxfordjournals.qjmed.a067266","article-title":"The liver in ulcerative colitis","volume":"40","author":"Perrett, A.D.; Higgins, G.; Johnston, H.H.; Massarella, G.R.; Truelove, S.C.; Wright, R.","year":"1971","unstructured":"Perrett AD, Higgins G, Johnston HH, Massarella GR, Truelove SC, Wright R. The liver in ulcerative colitis. QJMed 1971;40:211-38.","journal-title":"QJMed"},{"key":"ref_8","first-page":"113","article-title":"The spectrum of hepatic dysfunction in inflammatory bowel disease","volume":"48","author":"Dew, M.J.; Thompson, H.; Allan, R.","year":"1979","unstructured":"Dew MJ, Thompson H, Allan R. The spectrum of hepatic dysfunction in inflammatory bowel disease. Q J Med 1979;48:113-35.","journal-title":"Q J Med"},{"key":"ref_9","first-page":"155","article-title":"Ultrastructural aspects of liver injury with special reference to small bile ducts in patients with ulcerative colitis","volume":"12","author":"Mattila, J.; Pitkanen, R.; Halonen, P.; Matikainen, M.","year":"1992","unstructured":"Mattila J, Pitkanen R, Halonen P, Matikainen M. Ultrastructural aspects of liver injury with special reference to small bile ducts in patients with ulcerative colitis. Liver 1992;12:155-60.","journal-title":"Liver"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1055\/s-2007-1012796","article-title":"Septicemia after endoscopic retrograde cholangiopancreatography","volume":"22","author":"Deviere, J.; Motte, S.; Dumonceau, J.M.; Serruys, E.; Thys, J.P.; Cremer, M.","year":"1990","unstructured":"Deviere J, Motte S, Dumonceau JM, Serruys E, Thys JP, Cremer M. Septicemia after endoscopic retrograde cholangiopancreatography. Endoscopy 1990;22:72-5.","journal-title":"Endoscopy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1055\/s-2007-1012830","article-title":"Antibiotic prophylaxis of infectious complications with endoscopic retrograde cholangiopancreatography. A randomized controlled study","volume":"22","author":"Sauter, G.; Grabein, B.; Huber, G.; Mannes, G.A.; Ruckdeschel, G.; Sauerbruch, T.","year":"1990","unstructured":"Sauter G, Grabein B, Huber G, Mannes GA, Ruckdeschel G, Sauerbruch T. Antibiotic prophylaxis of infectious complications with endoscopic retrograde cholangiopancreatography. A randomized controlled study. Endoscopy 1990;22: 164-7.","journal-title":"Endoscopy"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1055\/s-2008-1040621","article-title":"Diagnosis and treatment of primary sclerosing cholangitis","volume":"5","author":"Wiesner, R.H.; Ludwig, J.; LaRusso, N.F.; MacCarty, R.L.","year":"1985","unstructured":"Wiesner RH, Ludwig J, LaRusso NF, MacCarty RL. Diagnosis and treatment of primary sclerosing cholangitis. Semin Liver Dis 1985;5:241-53.","journal-title":"Semin Liver Dis"},{"key":"ref_13","first-page":"404","article-title":"Liver: Structure and Function","author":"Popper, H.; Schaffner, F.","year":"1957","unstructured":"Popper H, Schaffner F. Liver: Structure and Function. New York: McGraw-Hill, 1957:404-7."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/0016-5085(88)90378-2","article-title":"Primary sclerosing cholangitis with normal serum alkaline phosphatase activity","volume":"95","author":"Balasubramaniam, K.; Wiesner, R.H.; LaRusso, N.F.","year":"1988","unstructured":"Balasubramaniam K, Wiesner RH, LaRusso NF. Primary sclerosing cholangitis with normal serum alkaline phosphatase activity. Gastroenterology 1988;95:1395-8.","journal-title":"Gastroenterology"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.47.11.1019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:53:14Z","timestamp":1765011194000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.47.11.1019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1994,11,1]]},"published-print":{"date-parts":[[1994,11]]}},"alternative-id":["10.1136\/jcp.47.11.1019"],"URL":"https:\/\/doi.org\/10.1136\/jcp.47.11.1019","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11]]}}}