{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:20:44Z","timestamp":1782602444709,"version":"3.54.5"},"reference-count":6,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:p>AIMS--To draw attention to non-neoplastic inclusions in axillary lymph nodes removed from women with primary breast cancer which may be mistaken for metastases. METHODS--Five examples of non-malignant inclusions were detected in axillary lymph nodes removed from women with mammary carcinoma. Immunohistochemical staining for CAM 5.2 and S100 markers, as well as morphological assessment were performed. RESULTS--Three of the five cases comprised naevus cells and two heterotopic epithelial elements. One of each was initially mistaken for metastatic carcinoma. Naevus cells in the capsule of axillary nodes are often arranged as lines of small, round cells and may readily be misinterpreted as metastatic lobular carcinoma. Heterotopic epithelial elements, in the form of tubules, can easily be mistaken for metastasis from an infiltrating ductal carcinoma. CONCLUSIONS--Awareness of the occasional occurrence of non-neoplastic nodal inclusions will help avoid misdiagnosis. If immunohistochemical markers for epithelial cells are used to screen lymph nodes for metastasis, such lesions could be detected more frequently. It is important to combine immunohistochemistry with morphological assessment and the use of a panel of antibodies in histological diagnosis.<\/jats:p>","DOI":"10.1136\/jcp.47.3.245","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"245-247","source":"Crossref","is-referenced-by-count":82,"title":["Benign lymph node inclusions mimicking metastatic carcinoma."],"prefix":"10.1136","volume":"47","author":[{"given":"C J","family":"Fisher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R R","family":"Millis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/1097-0142(197701)39:1<164::AID-CNCR2820390127>3.0.CO;2-T","article-title":"Nevus cell aggregates associated with lymph nodes: estimated frequency and clinical significance","volume":"39","author":"Ridolfi, R.L.; Rosen, P.P.; Thaler, H.","year":"1977","unstructured":"Ridolfi RL, Rosen PP, Thaler H. Nevus cell aggregates associated with lymph nodes: estimated frequency and clinical significance. Cancer 1977;39: 164-71.","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3109\/00313027409077346","article-title":"Nevus cells in lymph nodes","volume":"6","author":"McCarthy, S.W.; Palmer, A.A.; Bale, P.M.; Hirst, E.","year":"1974","unstructured":"McCarthy SW, Palmer AA, Bale PM, Hirst E. Nevus cells in lymph nodes. Pathology 1974;6:351-8.","journal-title":"Pathology"},{"issue":"23","key":"ref_3","first-page":"747","article-title":"Benign nevus cells in the capsule of lymph nodes","volume":"1969","author":"Johnson, W.T.; Helwig, E.B.","unstructured":"Johnson WT, Helwig EB. Benign nevus cells in the capsule of lymph nodes. Cancer 1969;23:747-53.","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2559.1980.tb02958.x","article-title":"Breast tissue inclusions in axillary lymph nodes","volume":"4","author":"Turner, D.R.; Millis, R.R.","year":"1980","unstructured":"Turner DR, Millis RR. Breast tissue inclusions in axillary lymph nodes. Histopathology 1980;4:631-6.","journal-title":"Histopathology"},{"key":"ref_5","first-page":"141","article-title":"Papillary carcinoma arising from ectopic breast tissue in an axillary lymph node","volume":"4","author":"Walker, A.N.; Fechner, R.E.","year":"1982","unstructured":"Walker AN, Fechner RE. Papillary carcinoma arising from ectopic breast tissue in an axillary lymph node. Diagnostic Gynecology and Obstetrics 1982;4:141-5.","journal-title":"Diagnostic Gynecology and Obstetrics"},{"key":"ref_6","first-page":"226","article-title":"Benign axillary epithelial lymph node inclusions-a histological pitfall","volume":"41","author":"Holdsworth, P.J.; Hopkinson, J.M.; Leveson, S.H.","year":"1988","unstructured":"Holdsworth PJ, Hopkinson JM, Leveson SH. Benign axillary epithelial lymph node inclusions-a histological pitfall. _J Clin Pathol 1988;41:226-8.","journal-title":"_J Clin Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.47.3.245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:51:08Z","timestamp":1763747468000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.47.3.245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1994,3,1]]},"published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1136\/jcp.47.3.245"],"URL":"https:\/\/doi.org\/10.1136\/jcp.47.3.245","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}