{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:16:28Z","timestamp":1767665788839,"version":"3.46.0"},"reference-count":3,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:p>AIMS--To compare the titre of anti-ganglioside antibodies (AGA) to GM1 ganglioside in patients with central and peripheral neurological disease and pure motor and sensorimotor neuropathy, in patients with classic autoimmune diseases, and controls. METHODS--AGA to GM1 were measured using an enzyme linked immunosorbent assay (ELISA) technique, highly purified bovine GM1 ganglioside, and sequential dilution of control and test sera. Antibody titre was calculated using the optical density readings of three consecutive serum dilutions multiplied by the dilution factor. RESULTS--A considerable overlap was evident in the titre of AGA to GM1 in control and test sera. High antibody titres were most frequent in patients with multifocal motor neuropathy with conduction block (MMNCB). Low AGA titre were observed in several patient groups. Compared with the controls, the median titre of AGA to GM1 was significantly higher in patients with multiple sclerosis, rheumatoid arthritis, primary Sj\u00f6gren's syndrome and systemic lupus erythematosus. In contrast, the median titre in patients with diabetic peripheral neuropathy, motor neurone disease, sensorimotor neuropathy and chronic inflammatory demyelinating polyneuropathy was no different from that in normal control subjects. CONCLUSIONS--Estimation of AGA to GM1 may be helpful in the diagnosis of MMNCB in patients with a pure motor neuropathy but in few other conditions. Low titre AGA to GM1 are evident in several autoimmune conditions. The pathogenetic importance of AGA to GM1 in patients with neuropathy is not clear.<\/jats:p>","DOI":"10.1136\/jcp.47.4.300","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"300-302","source":"Crossref","is-referenced-by-count":28,"title":["IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls."],"prefix":"10.1136","volume":"47","author":[{"given":"A S","family":"Bansal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Abdul-Karim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Malik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Goulding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Pumphrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Boulton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P L","family":"Holt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P B","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/mus.880141002","article-title":"Motor neuropathies, motor neurone disorders and antiglycolipid antibodies","volume":"14","author":"Pestronk, A.","year":"1991","unstructured":"Pestronk A. Motor neuropathies, motor neurone disorders and antiglycolipid antibodies. Muscle Nerve 1991;14: 927-36.","journal-title":"Muscle Nerve"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1172\/JCI109999","article-title":"Antiglycolipid autoantibody detected in the sera from systemic lupus erythematosus patients","volume":"66","author":"Hirano, T.; Hashimoto, H.; Shiokawa, Y.; Iwamori, M.; Nagai, Y.; Kasai, M.","year":"1980","unstructured":"Hirano T, Hashimoto H, Shiokawa Y, Iwamori M, Nagai Y, Kasai M,et al. Antiglycolipid autoantibody detected in the sera from systemic lupus erythematosus patients. J Clin Invest 1980;66:1437-40.","journal-title":"J Clin Invest"},{"key":"ref_3","first-page":"385","volume":"31","author":"Santoro, M.; Uncini, A.; Corbo, M.; Staugaitis, S.M.; Hays, A.P.","year":"1992","unstructured":"Santoro M, Uncini A, Corbo M, Staugaitis SM, Hays AP, Lsaetrouvm Nf.romExpaerpiatmieennttalwicthondauncttii-oGnMlbloacnktibiondideusc.edAnbny Neurol 1992;31:385-90.","journal-title":"Lsaetrouvm Nf.romExpaerpiatmieennttalwicthondauncttii-oGnMlbloacnktibiondideusc.edAnbny Neurol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.47.4.300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:36:12Z","timestamp":1764995772000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.47.4.300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":3,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1994,4,1]]},"published-print":{"date-parts":[[1994,4]]}},"alternative-id":["10.1136\/jcp.47.4.300"],"URL":"https:\/\/doi.org\/10.1136\/jcp.47.4.300","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}