{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:44:38Z","timestamp":1765712678332,"version":"3.48.0"},"reference-count":14,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:p>AIMS--To investigate and characterise the appearance of non-transferrin bound iron (NTBI) in the serum of patients after cytotoxic chemotherapy and to compare this with the onset and duration of neutropenia. METHOD--Non-transferrin bound iron was measured by a bleomycin assay in patients undergoing intensive chemotherapy for treatment of acute leukaemia or lymphoma. RESULTS--NTBI was detected after 26 of 27 courses of chemotherapy and lasted for a mean of 14.5 days. The presence of NTBI correlated with the serum iron binding saturation, but not with serum ferritin. Neutropenia occurred after all courses of chemotherapy and lasted for a mean of 20.0 days. NTBI and neutropenia occurred concurrently after 23 courses of chemotherapy, and had a mean joint duration of 9.5 days. CONCLUSIONS--NTBI is consistently present in the serum of patients after cytotoxic chemotherapy, often at the same time as the patient is neutropenic. This may be an additional risk factor for the development of infective episodes after chemotherapy.<\/jats:p>","DOI":"10.1136\/jcp.47.4.350","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"350-352","source":"Crossref","is-referenced-by-count":40,"title":["Non-transferrin bound iron and neutropenia after cytotoxic chemotherapy."],"prefix":"10.1136","volume":"47","author":[{"given":"P","family":"Harrison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Marwah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R T","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Bareford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF01308057","article-title":"A non transferrin bound serum iron in idiopathic haemachromatosis","volume":"25","author":"Bately, R.G.; Lai Chung Fong, P.; Shamir, S.; Sherlock, S.","year":"1980","unstructured":"Bately RG, Lai Chung Fong P, Shamir S, Sherlock S. A non transferrin bound serum iron in idiopathic haemachromatosis. Dig Dis Sci 1980;25:340-6.","journal-title":"Dig Dis Sci"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-0609.1981.tb01641.x","article-title":"Non specific iron in patients with beta thalassaemia trait and chronic active hepatitis","volume":"26","author":"Fargion, S.; Capellini, M.D.; Sampietro, M.; Forelli, G.","year":"1981","unstructured":"Fargion S, Capellini MD, Sampietro M, Forelli G. Non specific iron in patients with beta thalassaemia trait and chronic active hepatitis. Scand Jf Haematol 1981;26: 161-7.","journal-title":"Scand Jf Haematol"},{"issue":"34","key":"ref_3","first-page":"441","article-title":"Elevated serum iron, low unbound transferrin and candidiasis in acute leukaemia","volume":"1969","author":"Caroline, L.; Rosner, F.; Kozinn, P.J.","unstructured":"Caroline L, Rosner F, Kozinn PJ. Elevated serum iron, low unbound transferrin and candidiasis in acute leukaemia. Blood 1969;34:441-51.","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/ajcp\/81.6.748","article-title":"Transferrin in disease II: defects in the regulation of transferrin saturation contribute to susceptibility to infection","volume":"81","author":"Hunter, R.L.; Bennett, B.; Towne, M.; Volger, W.R.","year":"1984","unstructured":"Hunter RL, Bennett B, Towne M, Volger WR. Transferrin in disease II: defects in the regulation of transferrin saturation contribute to susceptibility to infection. Am J Clin Pathol 1984;81:748-53.","journal-title":"Am J Clin Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/10715768609088066","article-title":"Iron complexes and their reactivity in the bleomycin assay for radical promoting loosely bound iron","volume":"2","author":"Gutteridge, J.M.C.; Hou, Y.","year":"1986","unstructured":"Gutteridge JMC, Hou Y. Iron complexes and their reactivity in the bleomycin assay for radical promoting loosely bound iron. Free Radic Res Commun 1986;2: 143-51.","journal-title":"Free Radic Res Commun"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1042\/bj1990263","article-title":"Superoxide dependant formation of hydroxyl radicals in the presence of iron salts","author":"Gutteridge, J.M.C.; Rowley, D.A.; Halliwell, B.","year":"1981","unstructured":"Gutteridge JMC, Rowley DA, Halliwell B. Superoxide dependant formation of hydroxyl radicals in the presence of iron salts. Biochemj 1981;199:263-5.","journal-title":"Biochemj"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0014-5793(88)81061-5","article-title":"Bleomycindetectable iron in the serum from leukaemic patients before and after chemotherapy","volume":"241","author":"Halliwell, B.; Aruoma, O.I.; Mufti, G.; Bomford, A.","year":"1988","unstructured":"Halliwell B, Aruoma OI, Mufti G, Bomford A. Bleomycindetectable iron in the serum from leukaemic patients before and after chemotherapy. FEBS Lett 1988;241: 202-4.","journal-title":"FEBS Lett"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00043426-198724000-00014","article-title":"Association of serum iron, serum transferrin saturation, and serum ferritin with survival in acute lymphoblastic leukaemia","volume":"9","author":"Potaznik, N.; Groshen, S.; Miller, D.; Bagin, R.; Bhalla, R.; Schwartz, M.; de Souza, M.","year":"1987","unstructured":"Potaznik N, Groshen S, Miller D, Bagin R, Bhalla R, Schwartz M, de Souza M. Association of serum iron, serum transferrin saturation, and serum ferritin with survival in acute lymphoblastic leukaemia. Am J Pediatr Hematol Oncol 1987;9:350-5.","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1152\/physrev.1984.64.1.65","article-title":"Iron withholding: a defence against infection and neoplasia","volume":"64","author":"Weinberg, E.D.","year":"1984","unstructured":"Weinberg ED. Iron withholding: a defence against infection and neoplasia. Physiol Rev 1984;64:65-102.","journal-title":"Physiol Rev"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1128\/IAI.51.3.966-968.1986","article-title":"Aerobactin-mediated iron uptake by Escherichia coli isolates from human extraintestinal infections","volume":"51","author":"Carbonetti, N.H.; Boonchai, S.; Parry, S.H.; Vaianen-Rhen, V.; Korhonen, T.K.; Williams, P.H.","year":"1986","unstructured":"Carbonetti NH, Boonchai S, Parry SH, Vaianen-Rhen V, Korhonen TK, Williams PH. Aerobactin-mediated iron uptake by Escherichia coli isolates from human extraintestinal infections. Infect Immun 1986;51:966-968.","journal-title":"Infect Immun"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/apa.1989.78.s361.53","article-title":"Iron and infection: the clinical evidence","volume":"361","author":"Oppenheimer, S.J.","year":"1989","unstructured":"Oppenheimer SJ, Iron and infection: the clinical evidence. Acta Paediatr Suppl 1989;361:53-62.","journal-title":"Acta Paediatr Suppl"},{"key":"ref_12","first-page":"237","article-title":"Iron and infection","volume":"20","author":"Brock, J.H.","year":"1987","unstructured":"Brock JH. Iron and infection. Haematologia 1987;20: 237-46.","journal-title":"Haematologia"},{"key":"ref_13","first-page":"387","article-title":"The effects of iron and transferrin on the response in serum-free cultures of mouse lymphocytes to concanavalin a and lipopolysaccharide","volume":"43","author":"Brock, J.H.","year":"1981","unstructured":"Brock JH. The effects of iron and transferrin on the response in serum-free cultures of mouse lymphocytes to concanavalin a and lipopolysaccharide. Immunology 1981;43:387-95.","journal-title":"Immunology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.4049\/jimmunol.132.2.851","article-title":"Effect of iron (III) in the presence of various ligands on the phagocytic and metabolic activity of human polymorphonuclear leukocytes","volume":"132","author":"BS, Van Asbeck; JJM, Marx; A, Struyvenberg; JH, Van Kats; J, Verhoef","year":"1984","unstructured":"Van Asbeck BS, Marx JJM, Struyvenberg A, Van Kats JH, Verhoef J. Effect of iron (III) in the presence of various ligands on the phagocytic and metabolic activity of human polymorphonuclear leukocytes. J Immunol 1984; 132:851-6.","journal-title":"J Immunol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.47.4.350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:42:28Z","timestamp":1765712548000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.47.4.350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1994,4,1]]},"published-print":{"date-parts":[[1994,4]]}},"alternative-id":["10.1136\/jcp.47.4.350"],"URL":"https:\/\/doi.org\/10.1136\/jcp.47.4.350","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}