{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:09:19Z","timestamp":1759342159663,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:p>AIMS--To investigate a female patient with a tumour mass of the terminal ileum, to define the nature of the tumour, and to correlate its morphology and behaviour with similar types of tumours of the large intestine and stomach. METHODS--Tissues obtained at colonoscopy, from hemicolectomy specimens, and from liver and peritoneal biopsy specimens were studied macroscopically, microscopically, histochemically, and immunohistochemically for epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), neuron specific enolase (NSE), and S100 protein. RESULTS--Macroscopic examination showed a tumour of the terminal ileum protruding into the caecum. Microscopically the tumour showed two components, one adenoma with moderate dysplasia and the other carcinoid tumour. The adenomatous component stained positively for EMA and CEA and negatively for NSE. The carcinoid component stained positively for NSE and negatively for EMA and CEA. Histochemically the carcinoid area was argyrophil positive and argentaffin negative. Only the carcinoid had metastasised, to the liver, peritoneum, and the lymph nodes, at the time of diagnosis. CONCLUSION--The morphological, histochemical, and immunohistochemical findings confirm the diagnosis of a composite adenoma-carcinoid tumour of the terminal ileum.<\/jats:p>","DOI":"10.1136\/jcp.47.5.427","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"427-429","source":"Crossref","is-referenced-by-count":12,"title":["Composite glandular-carcinoid tumour of the terminal ileum."],"prefix":"10.1136","volume":"47","author":[{"given":"N M","family":"Varghese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Zaitoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Senapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Theodossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/1097-0142(19810801)48:3<799::AID-CNCR2820480324>3.0.CO;2-Q","article-title":"Adenomas of small intestine-A clinicopathologic review of 51 cases and a study of their relationship to carcinoma","volume":"48","author":"Perzin, K.H.; Bridge, M.F.","year":"1981","unstructured":"Perzin KH, Bridge MF. Adenomas of small intestine-A clinicopathologic review of 51 cases and a study of their relationship to carcinoma. Cancer 1981;48:799-819.","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/BF02586737","article-title":"A composite tumour in tubulovillous adenoma of the rectum","volume":"21","author":"Mori, K.; Shinya, H.; Kalisman, M.","year":"1978","unstructured":"Mori K, Shinya H, Kalisman M. A composite tumour in tubulovillous adenoma of the rectum. Dis Colon Rectum 1978;21:506-9.","journal-title":"Dis Colon Rectum"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/00000478-198808000-00001","article-title":"Composite glandular-carcinoid tumours of the colon and rectum. Report of two cases","volume":"12","author":"Moyana, T.N.; Qizilbash, A.H.; Murphy, F.","year":"1988","unstructured":"Moyana TN, Qizilbash AH, Murphy F. Composite glandular-carcinoid tumours of the colon and rectum. 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