{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:11:29Z","timestamp":1773249089869,"version":"3.50.1"},"reference-count":31,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:p>AIMS--To evaluate further the relation between gastric malignant lymphoma of the mucosa associated lymphoid tissue (MALT) and Helicobacter pylori. METHODS--One hundred and sixty two surgical specimens of MALT lymphoma were retrospectively investigated to determine tumour type and inflammatory patterns. In 121 cases biopsy specimens obtained before surgery were available and stained with haematoxylin and eosin, periodic acid Schiff, Giemsa and Warthin-Starry stains. RESULTS--Residual lymphoid follicles were found less often in high grade malignant than in low grade malignant MALT lymphomas. Chronic active gastritis was shown within the mucosa at some distance from the tumours in 143 of 146 specimens. In all the cases for which biopsy specimens could be evaluated, colonisation of the mucosa by H pylori had occurred. Lymphoid follicles and lymphoid aggregates were detected in 82.7% of the antral, and in 85% of the body mucosa specimens. CONCLUSIONS--These data support the hypothesis that H pylori has an important role in the development of MALT lymphomas. Furthermore, the chronic inflammation preceding malignant transformation might enhance the probability of malignant transformation via chronic stimulation of the lymphoid tissue. This might in part indicate why MALT lymphomas occur most often in the stomach.<\/jats:p>","DOI":"10.1136\/jcp.47.5.436","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"436-439","source":"Crossref","is-referenced-by-count":150,"title":["Helicobacter pylori gastritis and primary gastric non-Hodgkin's lymphomas."],"prefix":"10.1136","volume":"47","author":[{"given":"S","family":"Eidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Stolte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,5,1]]},"reference":[{"key":"ref_1","first-page":"1437","article-title":"Prospective double blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori","volume":"330","author":"Marshall, B.J.; Goodwin, C.S.; Warren, JR, Murray; R, Blincow; ED, Blackbourn; S.J.","year":"1988","unstructured":"Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ, et al. Prospective double blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet 1988;330:1437-42.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/0140-6736(91)93316-2","article-title":"Duodenal ulcer relapse after eradication of Helicobacter pylori","volume":"337","author":"Fiocca, L.; Solcia, E.; Santoro, B.","year":"1991","unstructured":"Fiocca L, Solcia E, Santoro B. Duodenal ulcer relapse after eradication of Helicobacter pylori. Lancet 1991; 337:1614.","journal-title":"Lancet"},{"key":"ref_3","article-title":"Results of treatment of Helicobacter pylori infection on the recurrence of gastric or duodenal ulcers: A randomized","volume-title":"single-blind, single center study. Gastroenterology 1991; 100: A 431","author":"Graham, D.Y.; Lew, G.M.; Kleine, P.D.; Evans, D.G.; Evans, D.J.; Saeed, Z.A.","unstructured":"Graham DY, Lew GM, Kleine PD, Evans DG, Evans DJ, Saeed ZA, et al. Results of treatment of Helicobacter pylori infection on the recurrence of gastric or duodenal ulcers: A randomized single-blind, single center study. Gastroenterology 1991;100:A 431."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/bmj.302.6788.1302","article-title":"Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation","volume":"302","author":"Forman, D.; Newell, D.G.; Fullerton, F.; Yarnell, J.W.G.; Stacey, A.R.; Wald, N.","year":"1991","unstructured":"Forman D, Newell DG, Fullerton F, Yarnell JWG, Stacey AR, Wald N. et al. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. 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Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175-6.","journal-title":"Lancet"},{"key":"ref_8","first-page":"142","article-title":"Immune response of the gastric mucosa to Campylobacter pylori","volume":"23","author":"Wyatt, J.I.; Rathbone, B.J.","year":"1988","unstructured":"Wyatt JI, Rathbone BJ. Immune response of the gastric mucosa to Campylobacter pylori. Scand J Gastroenterol 1988;23(suppl 142):44-9.","journal-title":"Scand J Gastroenterol"},{"key":"ref_9","first-page":"1269","article-title":"Lymphoid follicles of the antral mucosa: immune reaction to Campylobacter pylori? J7 Clin Pathol","volume":"42","author":"Stolte, M.; Eidt, S.","year":"1989","unstructured":"Stolte M, Eidt S. Lymphoid follicles of the antral mucosa: immune reaction to Campylobacter pylori? J7 Clin Pathol 1989;42: 1269-71."},{"key":"ref_10","first-page":"213","article-title":"Immunohistochemical patterns of the local immune response in Helicobacter pylori gastritis","volume-title":"gastnitis and peptic ulcer","author":"Kirchner, T.; Melber, A.; Fischbach, W.; Heilmann, K.L.; Miuller-Hermelink, H.K.","year":"1990","unstructured":"Kirchner T, Melber A, Fischbach W, Heilmann KL, Miuller-Hermelink HK. Immunohistochemical patterns of the local immune response in Helicobacter pylori gastritis. In: Malfertheimer P, Dischuneit H, eds. Helicobacter pyloi, gastnitis and peptic ulcer. Berlin: Springer, 1990:213-22."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/0140-6736(92)90280-G","article-title":"High incidence of primary gastric lymphoma in north eastern Italy","volume":"339","author":"Doglioni, C.; Wotherspoon, A.C.; Moschini, A.; De Boni, M.; Isaacson, P.G.","year":"1992","unstructured":"Doglioni C, Wotherspoon AC, Moschini A, De Boni M, Isaacson PG. High incidence of primary gastric lymphoma in north eastern Italy. Lancet 1992;339:834-5.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S0140-6736(88)90574-0","article-title":"Classifying primary gut lymphomas","volume":"330","author":"Isaacson, P.G.; Spencer, J.; Wright, D.H.","year":"1988","unstructured":"Isaacson PG, Spencer J, Wright DH. Classifying primary gut lymphomas. 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ZKrebsforschung 1975;83:323-8.","journal-title":"ZKrebsforschung"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/0016-5085(92)91723-H","article-title":"Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: factors relevant to prognosis","volume":"102","author":"Th, Radaskiewics; B, Dragosics; P, Bauer","year":"1992","unstructured":"Radaskiewics Th, Dragosics B, Bauer P. Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: factors relevant to prognosis. Gastroenterology 1992;102: 1628-38.","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1136\/gut.29.9.1258","article-title":"Lymphocytic gastritis: a newly described entity. A retrospective endoscopic and histological study","volume":"29","author":"Haot, J.; Hamuchi, L.; Walley, L.; Mainguet, P.","year":"1988","unstructured":"Haot J, Hamuchi L, Walley L, Mainguet P. Lymphocytic gastritis: a newly described entity. A retrospective endoscopic and histological study. Gut 1988;29:1258-64.","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/jcp.39.5.524","article-title":"Reflux gastritis: a distinct histopathological entity?","volume":"39","author":"Dixon, M.F.; O'Connor, H.J.; Axon, A.T.R.; King, R.F.J.; Johnston, D.","year":"1986","unstructured":"Dixon MF, O'Connor HJ, Axon ATR, King RFJ, Johnston D. Reflux gastritis: a distinct histopathological entity? J Clin Pathol 1986;39:524-30.","journal-title":"J Clin Pathol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0140-6736(92)90645-J","article-title":"Helicobacter pylori gastritis and gastric MALTlymphoma","volume":"339","author":"Stolte, M.","year":"1992","unstructured":"Stolte M. Helicobacter pylori gastritis and gastric MALTlymphoma. Lancet 1992;339:745-6.","journal-title":"Lancet"},{"key":"ref_19","first-page":"155","article-title":"Campylobacter pylori and non-ulcer dyspepsia","volume-title":"pylon and gastroduodenal disease","author":"Shallcross, T.M.; Rathbone, B.J.; Heatley, R.G.","year":"1989","unstructured":"Shallcross TM, Rathbone BJ, Heatley RG. Campylobacter pylori and non-ulcer dyspepsia. In: Rathbone BJ, Heatley RV, eds. Campylobacter pylon and gastroduodenal disease. Oxford: Blackwell Scientific Publications, 1989: 155-6."},{"key":"ref_20","first-page":"228","article-title":"Praxis der Gastritis-Klassifikation","volume":"4","author":"Stolte, M.; Bethke, B.; Ritter, M.; Lauer, E.; Eidt, H.","year":"1990","unstructured":"Stolte M, Bethke B, Ritter M, Lauer E, Eidt H. Praxis der Gastritis-Klassifikation. 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Frequency distribution of lymphoid follicles and lymphoid aggregates in Helicobacter pylori gastritis in antral and body mucosa of the stomach. Irish J Med Sci 1992;161(suppl 10):A14.","journal-title":"Irish J Med Sci"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000201116","article-title":"Antral intestinal metaplasia in Helicobacter pylori gastritis","volume":"55","author":"Eidt, S.; Stolte, M.","year":"1994","unstructured":"Eidt S, Stolte M. Antral intestinal metaplasia in Helicobacter pylori gastritis. Digestion 1994;55: 13-18.","journal-title":"Digestion"},{"key":"ref_24","first-page":"6","article-title":"Intestinal metaplasia and Helicobacter pylori: an endoscopic-bioptic study of the gastric antrum","volume":"33","author":"Craanen, M.E.; Decker, W.; Blok, P.; Ferweda, J.; Tytgat, G.N.J.","year":"1992","unstructured":"Craanen ME, Decker W, Blok P, Ferweda J, Tytgat GNJ. Intestinal metaplasia and Helicobacter pylori: an endoscopic-bioptic study of the gastric antrum. Gut 1992;33:6-10.","journal-title":"Gut"},{"key":"ref_25","first-page":"229","article-title":"Differences in the Helicobacter pylori associated gastritis in the antrum and body of the stomach","volume":"28","author":"Stolte, M.; Eidt, S.; Ohnsmann, A.","year":"1990","unstructured":"Stolte M, Eidt S, Ohnsmann A. Differences in the Helicobacter pylori associated gastritis in the antrum and body of the stomach. Z Gastroenterol 1990;28: 229-33.","journal-title":"Z Gastroenterol"},{"key":"ref_26","first-page":"81","article-title":"Follicular colonization in B-Cell lymphoma of mucosa-associated lymphoid tissue","volume":"15","author":"Isaacson, P.G.; Wotherspoon, A.C.; Diss, T.; Pan, L.","year":"1991","unstructured":"Isaacson PG, Wotherspoon AC, Diss T, Pan L. Follicular colonization in B-Cell lymphoma of mucosa-associated lymphoid tissue. Am j Surg Pathol 1991;15:81 9-28.","journal-title":"Am j Surg Pathol"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1097\/00000478-198712000-00008","article-title":"Persistent active Epstein-Barr virus infection and atypical lymphoproliferation","volume":"11","author":"Krueger, G.R.F.; Th, Papdakis; Schaefer, H.J.","year":"1987","unstructured":"Krueger GRF, Papdakis Th, Schaefer HJ. Persistent active Epstein-Barr virus infection and atypical lymphoproliferation. AmJ Surg Pathol 1987; 11:972-81.","journal-title":"AmJ Surg Pathol"},{"key":"ref_28","first-page":"114","article-title":"Epstein-Barr virus as an etiological agent in the pathogenesis of lymphoproliferative and aproliferative diseases in immune deficient patients","volume":"27","author":"Puertilo, D.T.; Tatsumi, E.; Manolov, G.; Manolova, Y.; Harada, S.; Lipscomb, H.","year":"1985","unstructured":"Puertilo DT, Tatsumi E, Manolov G, Manolova Y, Harada S, Lipscomb H, et al. Epstein-Barr virus as an etiological agent in the pathogenesis of lymphoproliferative and aproliferative diseases in immune deficient patients. Int Rev Exp Pathol 1985;27: 114-82.","journal-title":"Int Rev Exp Pathol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#","article-title":"Occurrence and prognosis of extranodal lymphomas","volume":"29","author":"Freeman, C.; Berg, J.W.; Cutler, S.J.","year":"1972","unstructured":"Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer 1972;29:252-60.","journal-title":"Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/1097-0142(19800701)46:1<215::AID-CNCR2820460136>3.0.CO;2-6","article-title":"Gastrointestinal involvement in nonHodgkin's lymphomas","volume":"46","author":"Herrman, R.; Panahon, A.M.; Barcos, M.P.; Walsh, D.; Stutzman, L.","year":"1980","unstructured":"Herrman R, Panahon AM, Barcos MP, Walsh D, Stutzman L. Gastrointestinal involvement in nonHodgkin's lymphomas. Cancer 1980;46:215-22.","journal-title":"Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/bjc.1989.351","article-title":"Primary gastrointestinal lymphoma in a populationbased registry","volume":"60","author":"Otter, R.; Bieger, R.; PhM, Kluin; Hermans, J.; Willemze, R.","year":"1989","unstructured":"Otter R, Bieger R, Kluin PhM, Hermans J, Willemze R. Primary gastrointestinal lymphoma in a populationbased registry. 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