{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:06:15Z","timestamp":1764493575860,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:p>Lymphoblastic transformation of polycythaemia rubra vera is an extremely rare phenomenon. A case of a 76 year old man with polycythaemia rubra vera who developed acute lymphoblastic leukaemia (ALL) 16 years after his initial diagnosis is reported. Membrane markers showed a CD10 positive (common ALL) immunophenotype. To our knowledge this association has not been previously recorded. The rare occurrence of ALL in polycythaemia rubra vera may indicate that in a minority of patients clonal expansion of an abnormal pluripotent haemopoietic stem cell is responsible for the polycythaemia rubra vera disease phenotype.<\/jats:p>","DOI":"10.1136\/jcp.47.5.471","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"471-472","source":"Crossref","is-referenced-by-count":10,"title":["Polycythaemia rubra vera transforming to acute lymphoblastic leukaemia with a common immunophenotype."],"prefix":"10.1136","volume":"47","author":[{"given":"J R","family":"Neilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W N","family":"Patton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M D","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E E","family":"Mayne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B J","family":"Boughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0002-9343(86)90029-X","article-title":"Terminal lymphoblastic transformation in polycythaemia vera","volume":"80","author":"Braich, T.A.; Grogan, T.M.; Hicks, M.J.; Greenberg, B.R.","year":"1986","unstructured":"Braich TA, Grogan TM, Hicks MJ, Greenberg BR. 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Ann Intern Med 1978;89:7 1.","journal-title":"Ann Intern Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/1097-0142(197905)43:5<1862::AID-CNCR2820430540>3.0.CO;2-K","article-title":"Polycythaemia vera in a child with acute lymphoblastic leukaemia","volume":"43","author":"Hann, H.L.; Feta, R.S.; Rosenstock, J.G.; Cifuentes, E.","year":"1979","unstructured":"Hann HL, Feta RS, Rosenstock JG, Cifuentes E. Polycythaemia vera in a child with acute lymphoblastic leukaemia. Cancer 1979;43: 1862-5.","journal-title":"Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ajh.2830290108","article-title":"Acute lymphoblastic leukaemia in a patient with longstanding polycythaemia vera: Cytogenetic analysis reveals two distinct clones","volume":"29","author":"Anastasi, J.; Pettenati, M.J.; Le Beau, M.M.; Kwaan, H.C.; Weil, S.C.","year":"1988","unstructured":"Anastasi J, Pettenati MJ, Le Beau MM, Kwaan HC, Weil SC. Acute lymphoblastic leukaemia in a patient with longstanding polycythaemia vera: Cytogenetic analysis reveals two distinct clones. Am J7 Hematol 1988;29: 33-7.","journal-title":"Am J7 Hematol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1136\/jcp.46.7.668","article-title":"Immunophenotypic characterisation of acute leukaemia after Polycythaemia vera","volume":"46","author":"Hernandez, J.M.; Orfao, A.; Gonzalez, M.","year":"1993","unstructured":"Hernandez JM, Orfao A, Gonzalez M, et al. Immunophenotypic characterisation of acute leukaemia after Polycythaemia vera. Clin Pathol 1993;46:668-7 1.","journal-title":"Clin Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.47.5.471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:17:04Z","timestamp":1758820624000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.47.5.471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5]]},"references-count":6,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1994,5,1]]},"published-print":{"date-parts":[[1994,5]]}},"alternative-id":["10.1136\/jcp.47.5.471"],"URL":"https:\/\/doi.org\/10.1136\/jcp.47.5.471","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1994,5]]}}}