{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:25:58Z","timestamp":1764998758943,"version":"3.46.0"},"reference-count":11,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>AIMS--To evaluate the role of bilharzial hepatic fibrosis--whether pure or combined with chronic hepatitis B virus infection--on the functional activity of vitamin K dependent coagulation proteins. METHODS--Coagulation screening using prothrombin time (PT), partial thromboplastin time (PTT), and thrombin time (TT) was carried out on 31 patients with endemic Egyptian hepatosplenomegaly and on 14 healthy controls. The functional activities of factors II, VII, IX and X and protein C were measured. Patients were classified as pure hepatosplenic schistosomiasis (n = 17) and schistosomiasis with concomitant chronic hepatitis B virus infection (n = 14). RESULTS--Prolongation of the PT and PTT were noticed in bilharzial patients compared with the controls. The increase in the TT remained within the upper range of normal. Factors II, VII, IX and X and protein C functional activities were significantly reduced in all groups studied. CONCLUSION--The decreased activity of vitamin K dependent coagulation factors might be partially offset by the reduced activity of circulating protein C which tends to establish a haemostatic balance at a lower level in endemic Egyptian hepatosplenomegaly. No significant difference could be shown between the pure and mixed cases. Schistosomal coagulopathy is therefore not necessarily aggravated by chronic hepatitis B virus infection.<\/jats:p>","DOI":"10.1136\/jcp.47.6.502","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"502-504","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin K dependent coagulation proteins in endemic hepatosplenomegaly in Egypt."],"prefix":"10.1136","volume":"47","author":[{"given":"S A","family":"Omran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N E","family":"el-Bassiouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F M","family":"Essawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Toiema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0016-5085(76)80557-4","article-title":"Hepatitis B surface antigen carrier state in hepatosplenic schistosomiasis","volume":"71","author":"Lyra, L.G.; Reboucas, G.; Andrade, Z.A.","year":"1976","unstructured":"Lyra LG, Reboucas G, Andrade ZA. Hepatitis B surface antigen carrier state in hepatosplenic schistosomiasis. 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Absence of relationship between schistosomiasis and hepatitis B virus infection in the Qalyub Govemate, Egypt Ann Trop Med Parasiwl 1987;81: 373-5.","journal-title":"Govemate, Egypt Ann Trop Med Parasiwl"},{"key":"ref_4","first-page":"17","article-title":"In vitro effect of Schistosoma worm antigen on some haemostatic parameters in hepatosplenic schistosomiasis","volume":"12","author":"Omran, S.A.; Toiema, S.M.; Shams El-Din, A.","year":"1990","unstructured":"Omran SA, Toiema SM, Shams El-Din A. In vitro effect of Schistosoma worm antigen on some haemostatic parameters in hepatosplenic schistosomiasis. The Egyptian J3ournal of Bilharziasis 1990;12:17-34."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000214643","article-title":"Factor VII in liver cirrhosis","volume":"11","author":"Orlando, M.; Casalbore, P.; Camagna, A.; Lauro, R.; Tardella, L.; Hassan, H.J.","year":"1982","unstructured":"Orlando M, Casalbore P, Camagna A, Lauro R, Tardella L, Hassan HJ. Factor VII in liver cirrhosis. Thromb Haemostas 1982;11:73-8.","journal-title":"Thromb Haemostas"},{"key":"ref_6","first-page":"113","article-title":"Coagulation factors as indices of protein synthesis in chronic liver disease","volume":"8","author":"Ritland, S.; Skrede, S.; Blomhoff, J.P.; Gjone, E.","year":"1983","unstructured":"Ritland S, Skrede S, Blomhoff JP, Gjone E. Coagulation factors as indices of protein synthesis in chronic liver disease. ScandJ3 Gastroenterol 1983;8:113-7."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000214335","article-title":"Correlation analysis of relationship between vitamin K-dependent clotting factors and effective hepatic blood flow, albumin, and other liver function tests","volume":"9","author":"Fujii, M.; Yasunaga, K.; Uchino, H.","year":"1980","unstructured":"Fujii M, Yasunaga K, Uchino H. Correlation analysis of relationship between vitamin K-dependent clotting factors and effective hepatic blood flow, albumin, and other liver function tests. Thromb Haemostas 1980;9: 9-14.","journal-title":"Thromb Haemostas"},{"key":"ref_8","first-page":"858","article-title":"Impaired coagulation factor synthesis is more important than impaired carboxylation in the coagulopathy of liver disease","volume":"3","author":"Feldshon, S.D.; Earnest, D.L.; Corrigan, J.J.","year":"1983","unstructured":"Feldshon SD, Earnest DL, Corrigan JJ. Impaired coagulation factor synthesis is more important than impaired carboxylation in the coagulopathy of liver disease. Hepatol 1983;3:858.","journal-title":"Hepatol"},{"key":"ref_9","first-page":"237","article-title":"Prealbumin, prekallikrein and prothrombin in hepatosplenic schistosomiasis; Increased turnover of the clotting proteins. Revista Do Instituto","volume":"26","author":"De Medecina Tropical De Sao Paulo","year":"1984","unstructured":"Manoukian N, Borges DR. Prealbumin, prekallikrein and prothrombin in hepatosplenic schistosomiasis; Increased turnover of the clotting proteins. 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