{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:46:06Z","timestamp":1789922766078,"version":"4.0.1"},"reference-count":9,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>A 74 year old man presented with signs and symptoms of mild cardiac failure. His face and chest were severely discoloured, which was thought to be due to cyanosis. He deteriorated and died of bronchopneumonia. At post mortem examination multiple organs, including the skin, showed silver pigment deposition; he also had a gastric malignant neuroendocrine tumour. He gave no history of contact with silver compounds. Systemic argyria caused by chronic ingestion of silver compounds is a rare condition which, apart from its cosmetic effects, is thought to be relatively harmless; it is not thought to be carcinogenic. This condition can pose diagnostic problems for both clinicians and pathologists.<\/jats:p>","DOI":"10.1136\/jcp.47.6.556","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"556-557","source":"Crossref","is-referenced-by-count":20,"title":["Systemic argyria."],"prefix":"10.1136","volume":"47","author":[{"given":"R J","family":"Prescott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,6,1]]},"reference":[{"key":"ref_1","first-page":"703","article-title":"Inorganic constituents. In: Histochemistry, theoretical and applied","author":"Pearse, A.G.E.","year":"1961","unstructured":"Pearse AGE. Inorganic constituents. In: Histochemistry, theoretical and applied. 3rd edn. Edinburgh: Churchill Livingstone, 1961:703-4.","edition":"3rd edn"},{"key":"ref_2","first-page":"115","article-title":"Silver and other metals. In: Handbook of materia medica, pharmacy and therapeutics","volume":"1892","author":"Potter, S.O.L.","unstructured":"Potter SOL. Silver and other metals. In: Handbook of materia medica, pharmacy and therapeutics. 4th edn. Philadelphia: Blakiston, 1892:115-6.","edition":"4th edn","journal-title":"Philadelphia: Blakiston"},{"key":"ref_3","article-title":"Argyria: the pharmacology of silver","author":"Hill, W.R.; Pillsbury, D.M.","year":"1939","unstructured":"Hill WR, Pillsbury DM. Argyria: the pharmacology of silver. 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Localised argyria. Arch Dermatol 1963;88: 531-9.","journal-title":"Arch Dermatol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0002-9149(72)90075-6","article-title":"Argyria presenting as cyanotic heart disease","volume":"30","author":"Rich, L.L.; Epinette, W.W.; Nasser, W.K.","year":"1972","unstructured":"Rich LL, Epinette WW, Nasser WK. Argyria presenting as cyanotic heart disease. Am Y Cardiol 1972;30:290-2.","journal-title":"Am Y Cardiol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1056\/NEJM194204232261703","article-title":"Argyria confused with heart disease","volume":"226","author":"Levine, S.A.; Smith, J.A.","year":"1942","unstructured":"Levine SA, Smith JA. Argyria confused with heart disease. N EngJMed 1942;226:682-4.","journal-title":"N EngJMed"},{"key":"ref_9","first-page":"250","article-title":"Pigmentation of the skin and disorders of melanin metabolism. In: Harrison's principles of intemal medicine","author":"Wintrobe, M.M.; Thorn, G.W.; Adams, R.D.","year":"1978","unstructured":"Wintrobe MM, Thorn GW, Adams RD, et al. Pigmentation of the skin and disorders of melanin metabolism. In: Harrison's principles of intemal medicine. New York: McGraw-Hill Book Co, 1978:250-5."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.47.6.556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:52:53Z","timestamp":1765007573000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.47.6.556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":9,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1994,6,1]]},"published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1136\/jcp.47.6.556"],"URL":"https:\/\/doi.org\/10.1136\/jcp.47.6.556","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6]]}}}