{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:54:58Z","timestamp":1775267698035,"version":"3.50.1"},"reference-count":28,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p>AIMS--To assess the role of Ki67 immunoreactivity in predicting the clinical progress of hydatidiform mole. METHODS--Tissue from 87 hydatidiform moles, 11 normal first trimester placentas, 11 normal term placentas and 17 spontaneous abortions were examined for expression of Ki67 antigen, using the monoclonal antibody MIB1. RESULTS--Ki67 immunoreactivity was significantly higher in the tissue from normal first trimester placentas than in that from normal term placentas and spontaneous abortions. Among the 87 patients with hydatidiform moles studied, 20 developed persistent gestational trophoblastic disease and required subsequent treatment. There was no statistically significant difference in the Ki67 index between the 20 patients who developed persistent disease and those who did not. CONCLUSION--Hydatidiform moles which give rise to persistent trophoblastic disease do not have a higher proliferative rate than those which do not. The Ki67 index is not useful for predicting the prognosis of molar pregnancies.<\/jats:p>","DOI":"10.1136\/jcp.47.7.601","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"601-604","source":"Crossref","is-referenced-by-count":40,"title":["Assessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen."],"prefix":"10.1136","volume":"47","author":[{"given":"A N","family":"Cheung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Y","family":"Ngan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y L","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/978-1-4757-1942-0_24","article-title":"Gestational trophoblastic disease","volume-title":"Blaustein's pathology offemale genital tract","author":"Mazur, M.T.; Kurman, R.J.","year":"1987","unstructured":"Mazur MT, Kurman RJ. Gestational trophoblastic disease. In: Kurman RJ, ed. Blaustein's pathology offemale genital tract. New York: Springer-Verlag, 1987:835-75."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1471-0528.1972.tb12907.x","article-title":"The value of histological grading in the management of hydatidiform mole","volume":"79","author":"Elston, C.W.; Bagshawe, K.D.","year":"1972","unstructured":"Elston CW, Bagshawe KD. The value of histological grading in the management of hydatidiform mole. J Obstet Gynecol Br Commonwealth 1972;79:717-24.","journal-title":"J Obstet Gynecol Br Commonwealth"},{"key":"ref_3","first-page":"402","article-title":"A clinicopathologic study of 153 cases of complete hydatidiform mole ( 1080-1990): Histologic grade lacks prognostic significance","volume":"78","year":"1991","unstructured":"Genest DR, Laborde 0, Berkowitz RS, Goldstein DP, Bernstein MR, Lage J. A clinicopathologic study of 153 cases of complete hydatidiform mole (1080-1990): Histologic grade lacks prognostic significance. Obstet Gynecol 1991;78:402-9.","journal-title":"Obstet Gynecol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/jcp.43.3.184","article-title":"Review: assessment of cell proliferation in histological material","volume":"43","author":"DA, Hall P.A.Levison","year":"1990","unstructured":"Hall PA. Levison DA. Review: assessment of cell proliferation in histological material. J Clin Pathol 1990;43: 184-92.","journal-title":"J Clin Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00004347-199204000-00007","article-title":"Review: the usefulness of clinical measurement of cell proliferation in gynaecological cancer","volume":"11","author":"Quinn, C.M.; Wright, N.A.","year":"1992","unstructured":"Quinn CM, Wright NA. Review: the usefulness of clinical measurement of cell proliferation in gynaecological cancer. IntI Gynaecol Pathol 1992;11: 131-43.","journal-title":"IntI Gynaecol Pathol"},{"key":"ref_6","first-page":"531","article-title":"Immunohistochemical markers of cellular proliferation: achievements, problems and prospects","volume":"23","author":"Hall, P.A.; Wood, A.L.","year":"1990","unstructured":"Hall PA, Wood AL. Immunohistochemical markers of cellular proliferation: achievements, problems and prospects. CeUl Tissue Kinet 1990;23:531-49.","journal-title":"CeUl Tissue Kinet"},{"key":"ref_7","first-page":"99","article-title":"Ki67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies","volume-title":"biology. Vol I","author":"Gerdes, J.","year":"1990","unstructured":"Gerdes J. Ki67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies. In: Osborn M, ed. Cancer biology. Vol I. London: Saunders Scientific Publications, 1990:99-206."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/path.1711680404","article-title":"Monoclonal antibodies against recombinant parts of the Ki67 antigen (MIB1 and MIB3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections","volume":"168","author":"Cattoretti, G.; Becker, M.H.G.; Key, G.; Duchrow, M.; Schluter, C.; Galle, J.; Gerdes, J.","year":"1992","unstructured":"Cattoretti G, Becker MHG, Key G, Duchrow M, Schluter C, Galle J, Gerdes J. Monoclonal antibodies against recombinant parts of the Ki67 antigen (MIB1 and MIB3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. Y Pathol 1992;168: 357-63.","journal-title":"Y Pathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2559.1993.tb00135.x","article-title":"Detection of the Ki67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIBI","volume":"22","author":"McCormick, Chong H.; C, Hobbs; C, Datta; PA, Hall","year":"1993","unstructured":"McCormick, Chong H, Hobbs C, Datta C, Hall PA. Detection of the Ki67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIBI. Histopathology 1993;22:355-60.","journal-title":"Histopathology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1365-2559.1993.tb00177.x","article-title":"The signifance of proliferating cell nuclear antigen in human trophoblastic disease: an immunohistochemical study","volume":"22","author":"Cheung, A.N.Y.; Ngan, H.Y.S.; Chen, W.Z.; Loke, S.L.; Collins, R.J.","year":"1993","unstructured":"Cheung ANY, Ngan HYS, Chen WZ, Loke SL, Collins RJ. The signifance of proliferating cell nuclear antigen in human trophoblastic disease: an immunohistochemical study. Histopathology 1993;22:565-8.","journal-title":"Histopathology"},{"key":"ref_11","first-page":"1045","article-title":"Gestation trophoblastic disease","volume-title":"obstetrcal and gynaecological pathology","author":"Elston, C.W.","year":"1987","unstructured":"Elston CW. Gestation trophoblastic disease. In: Fox H, ed. Haines and Taylor: obstetrcal and gynaecological pathology. Edinburgh: Churchill Livingstone, 1987: 1045-78."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0002-9378(78)90829-3","article-title":"The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations","volume":"131","author":"U, Szulman A.E.Surti","year":"1987","unstructured":"Szulman AE. Surti U. The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. AmY Obstet Gynecol 1987;131:665-71.","journal-title":"AmY Obstet Gynecol"},{"key":"ref_13","first-page":"1","article-title":"The modern managment of trophoblastic disease","volume-title":"advances in obstetrics and gynaecology","author":"Ma, H.K.; Wong, L.C.; Ngan, H.Y.S.","year":"1990","unstructured":"Ma HK, Wong LC, Ngan HYS. The modern managment of trophoblastic disease. In: Nonnar J, ed. Recent advances in obstetrics and gynaecology. Edinburgh: Churchill Livingstone, 1990: 1-23."},{"key":"ref_14","first-page":"1","article-title":"Hydatidiform mole: diagnosis, management and long term follow-up of 347 patients","volume":"45","author":"Curry, S.L.; Hammond, C.B.; Tyrey, L.; Creasman, W.T.; Parker, R.T.","year":"1975","unstructured":"Curry SL, Hammond CB, Tyrey L, Creasman WT, Parker RT. Hydatidiform mole: diagnosis, management and long term follow-up of 347 patients. Obstet Gynaecol 1975;45: 1-3.","journal-title":"Obstet Gynaecol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0002-9378(77)90562-2","article-title":"Clinical and Laboratory correlates of molar pregnancy and trophoblastic disease","volume":"128","author":"Morrow, C.P.; Kletxky, O.A.; Disaia, P.J.; Townsend, D.E.; Mishell, D.R.; Nakamura, R.M.","year":"1977","unstructured":"Morrow CP, Kletxky OA, Disaia PJ, Townsend DE, Mishell DR, Nakamura RM. Clinical and Laboratory correlates of molar pregnancy and trophoblastic disease. Am J Obstet Gynecol 1977;128:424-8.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0002-9378(72)90553-4","article-title":"A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone","volume":"113","author":"Vaitukaitis, J.L.; Braunstein, G.D.; Ross, G.T.","year":"1972","unstructured":"Vaitukaitis JL, Braunstein GD, Ross GT. A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone. Am J Obstet Gynecol 1972;113: 751-7.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ijc.2910310104","article-title":"Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation","volume":"31","author":"Gerdes, J.; Schwab, U.; Lemke, H.; Stein, H.","year":"1983","unstructured":"Gerdes J, Schwab U, Lemke H, Stein H. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 1983;31:13-20.","journal-title":"Int J Cancer"},{"key":"ref_18","first-page":"1710","article-title":"Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki67","volume":"133","author":"Gerdes, J.; Lemke, H.; Baisch, H.; Wacher, H.-H.; Schwab, U.; Stein, H.","year":"1984","unstructured":"Gerdes J, Lemke H, Baisch H, Wacher H-H, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki67. JImmunol 1984;133:1710-15."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/path.1711540305","article-title":"The prognostic significance of Ki67 immunostaining in non-Hodgkin's lymphoma","volume":"154","author":"Hall, P.A.; Gregory, W.; Richards, M.A.; D'Ardenne, A.J.; Lister, T.A.; Stansfeld, A.G.","year":"1988","unstructured":"Hall PA, Gregory W, Richards MA, D'Ardenne AJ, Lister TA, Stansfeld AG. The prognostic significance of Ki67 immunostaining in non-Hodgkin's lymphoma. J Pathol 1988;154:223-35.","journal-title":"J Pathol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2184.1992.tb01435.x","article-title":"Cell cycle dependent expression and stability of the nuclear protein detected by Ki67 antibody in HL60 cells","volume":"25","author":"Bruno, S.; Darzynltiewicz, Z.","year":"1992","unstructured":"Bruno S, Darzynltiewicz Z. Cell cycle dependent expression and stability of the nuclear protein detected by Ki67 antibody in HL60 cells. Cell Prolif 1992;25:31-40.","journal-title":"Cell Prolif"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/path.1711650213","article-title":"A comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fraction","volume":"165","author":"Scott, R.J.; Hall, P.A.; Haldane, J.S.","year":"1991","unstructured":"Scott RJ, Hall PA, Haldane JS, et al. A comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fraction. J Pathol 1991;165:173-8.","journal-title":"J Pathol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/15513819209023291","article-title":"Proliferating cell nuclear antigen in human placenta and trophoblastic disease","volume":"12","author":"Wolf, H.K.; Michalopoulos, G.K.","year":"1992","unstructured":"Wolf HK, Michalopoulos GK. Proliferating cell nuclear antigen in human placenta and trophoblastic disease. Pediatr Pathol 1992;12:147-54.","journal-title":"Pediatr Pathol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF00672281","article-title":"Regionale unterschiedliche Zellproliferation innerhalb der Plazentome reifer menschlichen Plazenten: autoradiographische Untersuchungen","volume":"218","author":"Geier, G.; Schuhmann, R.; Kraus, H.","year":"1975","unstructured":"Geier G, Schuhmann R, Kraus H. Regionale unterschiedliche Zellproliferation innerhalb der Plazentome reifer menschlichen Plazenten: autoradiographische Untersuchungen. Arch Gynakol 1975;218:31-7.","journal-title":"Arch Gynakol"},{"key":"ref_24","first-page":"13","article-title":"Continuing growth and development of the third trimester human placenta","volume":"6","author":"Sands, J.; Dobbing, J.","year":"1985","unstructured":"Sands J, Dobbing J. Continuing growth and development of the third trimester human placenta. P-lacenta 1985;6: 13-22.","journal-title":"P-lacenta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0378-3782(84)90074-4","article-title":"Quantitative studies of the normal human placenta from 10 weeks of gestation to term","volume":"9","author":"Boyd, P.A.","year":"1984","unstructured":"Boyd PA. Quantitative studies of the normal human placenta from 10 weeks of gestation to term. Early Hum Devel 1984;9:297-307.","journal-title":"Early Hum Devel"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/jcp.46.1.48","article-title":"Use of proliferating cell nuclear antigen immunoreactivity for distinguishing hydropic abortions from partial hydatidiform moles","volume":"46","author":"Suresh, U.R.; Hale, R.J.; Fox, H.; Buckley, C.H.","year":"1993","unstructured":"Suresh UR, Hale RJ, Fox H, Buckley CH. Use of proliferating cell nuclear antigen immunoreactivity for distinguishing hydropic abortions from partial hydatidiform moles. Y Clin Pathol 1993;46:48-50.","journal-title":"Y Clin Pathol"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0065-230X(08)60931-8","article-title":"Gestational trophoblastic disease: Origin of choriocarcinoma, invasive mole and choriocarcinoma associated with hydatidiform mole, and some immunological aspects","volume":"27","author":"Brewer, J.I.; Torok, E.E.; Kahan, B.D.; Stanhope, C.R.; Halpern, B.","year":"1978","unstructured":"Brewer JI, Torok EE, Kahan BD, Stanhope CR, Halpern B. Gestational trophoblastic disease: Origin of choriocarcinoma, invasive mole and choriocarcinoma associated with hydatidiform mole, and some immunological aspects. Adv Cancer Res 1978;27:89-147.","journal-title":"Adv Cancer Res"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0950-3552(05)80009-4","article-title":"The immune system in disease: gestational trophoblastic tumours","volume":"6","author":"Newlands, E.S.; Fisher, R.A.; Searle, F.","year":"1992","unstructured":"Newlands ES, Fisher RA, Searle F. The immune system in disease: gestational trophoblastic tumours. Baillieris Clin Obstet Gynaecol 1992;6:519-39.","journal-title":"Baillieris Clin Obstet Gynaecol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.47.7.601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:30:17Z","timestamp":1765600217000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.47.7.601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":28,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1994,7,1]]},"published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1136\/jcp.47.7.601"],"URL":"https:\/\/doi.org\/10.1136\/jcp.47.7.601","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}