{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:44:22Z","timestamp":1765082662034,"version":"3.46.0"},"reference-count":24,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:p>AIMS--To study the oesophageal histological changes in long term users of non-steroidal anti-inflammatory drugs (NSAIDs) compared with patients not receiving these drugs. METHODS--Ninety eight patients were studied, 53 of whom had taken NSAIDs for three years; 45 had not. Oesophageal biopsy specimens were taken from healthy-looking mucosa in the lower third of oesophagus. The papillary length, the thickness of the basal cell layer, and the intensity of cells infiltrating the epithelium were all assessed blind. RESULTS--The NSAID group included four (7%) cases of papillary elongation and two (4%) cases of basal cell hyperplasia, compared with 13 (29%; p &lt; 0.01) and eight (18%; p &lt; 0.02), respectively, in patients not taking NSAIDs. The total histological scores were also lower in patients treated with NSAIDs. CONCLUSION--Long term NSAID users have fewer oesophageal histological abnormalities than patients not receiving NSAIDs. Macroscopic damage related to NSAID use is, therefore, unlikely to require pre-existing histological oesophagitis for its development.<\/jats:p>","DOI":"10.1136\/jcp.47.8.705","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"705-708","source":"Crossref","is-referenced-by-count":18,"title":["Oesophageal histology in long term users of non-steroidal anti-inflammatory drugs."],"prefix":"10.1136","volume":"47","author":[{"given":"A S","family":"Taha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Dahill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Nakshabendi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F D","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R D","family":"Sturrock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R I","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,8,1]]},"reference":[{"key":"ref_1","first-page":"2","article-title":"Gastritis and duodenitis: the histopathological spectrum","volume":"4","author":"Dixon, M.F.; Sobala, G.M.","year":"1992","unstructured":"Dixon MF, Sobala GM. Gastritis and duodenitis: the histopathological spectrum. Eur J Gastroenterol Hepatol 1992;4(suppl 2):S17-23.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref_2","first-page":"2","article-title":"Long-term consequences of gastroduodenal inflammation","volume":"4","author":"Sipponen, P.","year":"1992","unstructured":"Sipponen P. Long-term consequences of gastroduodenal inflammation. Eur J Gastroenterol Hepatol 1992;4(suppl 2):S25-9.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/rheumatology\/27.2.87","article-title":"Non-steroidal anti-inflammatory drugsanother look","volume":"27","author":"Gibson, T.","year":"1989","unstructured":"Gibson T. Non-steroidal anti-inflammatory drugsanother look. BrJ Rheumatol 1989;27:87-90.","journal-title":"BrJ Rheumatol"},{"key":"ref_4","first-page":"926","article-title":"Current controversies in rheumatology. Controversies in detection and management of non-steroidal anti-inflammatory drug induced side-effects on upper gastrointestinal tract","volume":"32","author":"Barrier, C.H.; Hirschowitz, B.I.","year":"1989","unstructured":"Barrier CH, Hirschowitz BI. Current controversies in rheumatology. Controversies in detection and management of non-steroidal anti-inflammatory drug induced side-effects on upper gastrointestinal tract. Arthritis Rheum 1989;32:926-9.","journal-title":"Arthritis Rheum"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/jcp.45.2.135","article-title":"Chemical and Helicobacter pylori related gastritis in patients receiving non-steroidal anti-inflammatory drugs-comparison and correlation with peptic ulceration","volume":"45","author":"Taha, A.S.; Nakshabendi, I.; Lee, F.D.; Sturrock, R.D.; Russell, R.I.","year":"1992","unstructured":"Taha AS, Nakshabendi I, Lee FD, Sturrock RD, Russell RI. Chemical and Helicobacter pylori related gastritis in patients receiving non-steroidal anti-inflammatory drugs-comparison and correlation with peptic ulceration. Y Clin Pathol 1992;45:135-9.","journal-title":"Y Clin Pathol"},{"key":"ref_6","first-page":"1832","article-title":"Side effects of non-steroidal anti-inflammatory drugs on the small and large","volume-title":"intestine in humans. Gastroenterology 1993; 104","author":"Bjarnason, I.; Hayllar, J.; MacPherson, J.; Russell, A.S.","unstructured":"Bjarnason I, Hayllar J, MacPherson J, Russell AS. Side effects of non-steroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 1993;104: 1832-47."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/bmj.297.6652.833","article-title":"Non-steroidal anti-inflammatory drugs and pain-free peptic ulceration in the elderly","volume":"297","author":"Skander, M.P.; Ryan, F.P.","year":"1988","unstructured":"Skander MP, Ryan FP. Non-steroidal anti-inflammatory drugs and pain-free peptic ulceration in the elderly. Br MedJ 1988;297:833-4.","journal-title":"Br MedJ"},{"key":"ref_8","first-page":"203","article-title":"Nonsteroidal anti-inflammatory drugs and the oesophagusendoscopic and histological studies","volume":"104","author":"Taha, A.S.; Nakshabendi, I.; Sturrock, R.D.; Russell, R.I.","year":"1993","unstructured":"Taha AS, Nakshabendi I, Sturrock RD, Russell RI. Nonsteroidal anti-inflammatory drugs and the oesophagusendoscopic and histological studies. Gastroenterology 1993;104:A203.","journal-title":"Gastroenterology"},{"key":"ref_9","first-page":"15","article-title":"Pathophysiology of reflux oesophagitis","volume":"156","author":"Janssens, J.; Vantrappen, G.","year":"1989","unstructured":"Janssens J, Vantrappen G. Pathophysiology of reflux oesophagitis. Scand Gastroenterol 1989;156(suppl): 15-9.","journal-title":"Scand Gastroenterol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0016-5085(87)90142-9","article-title":"Gastric emptying of solid food in patients with gastrooesophageal reflux","volume":"92","author":"Shay, S.S.; Eggli, D.; McDonald, C.; Johnson, L.F.","year":"1987","unstructured":"Shay SS, Eggli D, McDonald C, Johnson LF. Gastric emptying of solid food in patients with gastrooesophageal reflux. Gastroenterology 1987;92:459-65.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/0016-5085(84)90201-4","article-title":"Effect of indomethacin on gastric acid and bicarbonate secretion in humans","volume":"87","author":"Feldman, M.; Colturic, T.J.","year":"1984","unstructured":"Feldman M, Colturic TJ. Effect of indomethacin on gastric acid and bicarbonate secretion in humans. Gastroenterology 1984;87: 1339-43.","journal-title":"Gastroenterology"},{"key":"ref_12","first-page":"756","article-title":"Non-salicylate nonsteroidal anti-inflammatory drugs augment pre-stimulated acid secretion in rabbit parietal cells","volume-title":"Investigations of the mechanisms of action. Gastroenterology 1991; 101","author":"Levine, R.A.; Jyotirmoy, N.; King, R.L.","unstructured":"Levine RA, Jyotirmoy N, King RL. Non-salicylate nonsteroidal anti-inflammatory drugs augment pre-stimulated acid secretion in rabbit parietal cells. Investigations of the mechanisms of action. Gastroenterology 1991;101: 756-65."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0262-1746(87)90003-5","article-title":"Oesophageal mucosal prostaglandin E, levels in health and gastrooesophageal reflux disease","volume":"29","author":"Ottignon, Y.; Alber, D.; Moussard, C.","year":"1987","unstructured":"Ottignon Y, Alber D, Moussard C. Oesophageal mucosal prostaglandin E, levels in health and gastrooesophageal reflux disease. Prostaglandins Leuk Med 1987;29:141-51.","journal-title":"Prostaglandins Leuk Med"},{"key":"ref_14","first-page":"881","article-title":"Radiation oesophagitis in the opossum; radioprotection with indomethacin","volume":"78","author":"Northway, M.G.; Libshitz, H.I.; Osborne, B.M.","year":"1980","unstructured":"Northway MG, Libshitz HI, Osborne BM. Radiation oesophagitis in the opossum; radioprotection with indomethacin. Gastroenterology 1980;78:881-92.","journal-title":"Gastroenterology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/ajplegacy.1972.222.4.967","article-title":"Cholinergic response of the lower oesophageal sphincter","volume":"222","author":"Rolling, G.T.; Farrell, R.L.; Castell, D.O.","year":"1972","unstructured":"Rolling GT, Farrell RL, Castell DO. Cholinergic response of the lower oesophageal sphincter. Am Y Physiol 1972;222:967-72.","journal-title":"Am Y Physiol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1152\/jappl.1987.62.5.1837","article-title":"Effect of endogenous prostaglandins on acetylcholine release from dog trachealis muscle","volume":"62","author":"Shore, S.; Collier, B.; Martin, J.G.","year":"1987","unstructured":"Shore S, Collier B, Martin JG. Effect of endogenous prostaglandins on acetylcholine release from dog trachealis muscle. YAppl Physiol 1987;62: 1837-44.","journal-title":"YAppl Physiol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1136\/jcp.38.11.1265","article-title":"Oesophageal histology in reflux oesophagitis","volume":"38","author":"Collins, B.J.; Elliot, H.; Sloan, J.M.; McFarland, R.J.; Love, A.H.G.","year":"1985","unstructured":"Collins BJ, Elliot H, Sloan JM, McFarland RJ, Love AHG. Oesophageal histology in reflux oesophagitis. Clin Pathol 1985;38:1265-72.","journal-title":"Clin Pathol"},{"key":"ref_18","first-page":"1127","article-title":"Drug-induced oesophagitis","volume":"86","author":"Eng, J.; Sabanathan, S.","year":"1991","unstructured":"Eng J, Sabanathan S. Drug-induced oesophagitis. Am Gastroenterol 1991;86:1127-33.","journal-title":"Am Gastroenterol"},{"key":"ref_19","first-page":"1086","article-title":"Pill-oesophagitis caused by non-steroidal anti-inflammatory drugs","volume":"86","author":"Minocha, A.; Greenbaum, D.S.","year":"1991","unstructured":"Minocha A, Greenbaum DS. Pill-oesophagitis caused by non-steroidal anti-inflammatory drugs. Am J7 Gastroenterol 1991;86: 1086-9.","journal-title":"Am J7 Gastroenterol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1136\/bmj.300.6730.1018-b","article-title":"Oesophageal lesions during treatment with piroxicam","volume":"300","author":"Santucci, L.; Patocia, L.; Fiorucci, S.; Farroni, F.; Favero, D.; Morelli, A.","year":"1990","unstructured":"Santucci L, Patocia L, Fiorucci S, Farroni F, Favero D, Morelli A. Oesophageal lesions during treatment with piroxicam. BMJ 1990;300:1018.","journal-title":"BMJ"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/BF01367672","article-title":"Beneficial effects of indomethacin on acid-induced oesophagitis in cats","volume":"26","author":"Eastwood, G.L.; Beck, B.D.; Castell, D.O.; Brown, F.C.; Fletcher, JR","year":"1981","unstructured":"Eastwood GL, Beck BD, Castell DO, Brown FC, Fletcher JR. Beneficial effects of indomethacin on acid-induced oesophagitis in cats. Dig Dis Sci 1981;26:601-8.","journal-title":"Dig Dis Sci"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0016-5085(89)90062-0","article-title":"Role of arachidonic acid metabolites in acid-pepsin injury to rabbit oesophagus","volume":"97","author":"Stein, B.E.; Schwartzman, M.L.; Carrol, M.A.; Stahl, R.E.; Rosenthal, W.S.","year":"1989","unstructured":"Stein BE, Schwartzman ML, Carrol MA, Stahl RE, Rosenthal WS. Role of arachidonic acid metabolites in acid-pepsin injury to rabbit oesophagus. Gastroenterol 1989;97:278-83.","journal-title":"Gastroenterol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJM197105202842007","article-title":"Inhibitory effect of smoking on the lower oesophageal sphincter","volume":"284","author":"Dennish, G.W.; Castell, D.O.","year":"1971","unstructured":"Dennish GW, Castell DO. Inhibitory effect of smoking on the lower oesophageal sphincter. N Engl Med 1971; 284:1136-7.","journal-title":"N Engl Med"},{"key":"ref_24","article-title":"Helicobacter pylori colonization and alteration in gastric physiology","volume-title":"pylon and gastroduodenal disease","author":"McColl, K.E.L.","year":"1992","unstructured":"McColl KEL. Helicobacter pylori colonization and alteration in gastric physiology. In: Rathbone BJ, Heatley RV, eds. Helicobacter pylon and gastroduodenal disease. 2nd edn. Oxford: Blackwell Scientific Publications, 1992: 198-208.","edition":"2nd edn"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.47.8.705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:32:32Z","timestamp":1765078352000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.47.8.705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":24,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1994,8,1]]},"published-print":{"date-parts":[[1994,8]]}},"alternative-id":["10.1136\/jcp.47.8.705"],"URL":"https:\/\/doi.org\/10.1136\/jcp.47.8.705","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}