{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:10:43Z","timestamp":1767373843997,"version":"3.46.0"},"reference-count":7,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:p>Human herpes virus 6 (HHV 6) has been implicated as the causative agent of exanthema subitum in young children. Recently, we reported two cases of a severe, infectious, mononucleosis-like syndrome resulting from a primary HHV 6 infection in immunocompetent adults. Both of these patients had the skin condition generally referred to as \"erythroderma\". A skin-biopsy specimen from one of them, a 43 year old man, was examined. Using immunohistochemical staining and in situ hybridisation, lymphocytes infected with HHV 6 were found in the skin. It is proposed that the erythroderma in immunocompetent adults infected with primary HHV 6 is provoked by infiltration of infected inflammatory cells or infected neoplastic lymphocytes into the dermis.<\/jats:p>","DOI":"10.1136\/jcp.47.8.762","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"762-763","source":"Crossref","is-referenced-by-count":11,"title":["Detection of human herpes virus 6 (HHV 6) in the skin of a patient with primary HHV 6 infection and erythroderma."],"prefix":"10.1136","volume":"47","author":[{"given":"Y","family":"Sumiyoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.2876520","article-title":"Isolation of new virus, HTLV, in patients with lymphoproliferative disorders","volume":"234","author":"Salahuddin, S.; Ablashi, D.V.; Markham, P.D.","year":"1986","unstructured":"Salahuddin S, Ablashi DV, Markham PD, et al. Isolation of new virus, HTLV, in patients with lymphoproliferative disorders. Science 1986;234:596-601.","journal-title":"Science"},{"key":"ref_2","first-page":"234","article-title":"Diverse tropism of human B-lymphotropic virus (human herpes virus-6)","volume":"ii:","author":"Lusso, P.; Salahuddin, S.Z.; Ablashi, D.V.","year":"1987","unstructured":"Lusso P, Salahuddin SZ, Ablashi DV, et al. Diverse tropism of human B-lymphotropic virus (human herpes virus-6). Lancet 1987;ii:234-4.","journal-title":"Lancet"},{"key":"ref_3","first-page":"1065","article-title":"Identification of human herpesvirus-6 as a causal agent for exanthema subitum","volume":"i:","author":"true","year":"1988","unstructured":"Yamanishi K, Toshiomi 0, Kimiyasu S, et al. Identification of human herpesvirus-6 as a causal agent for exanthema subitum. Lancet 1988;i: 1065-7.","journal-title":"Lancet"},{"key":"ref_4","article-title":"Human herpesvirus-6 lymphadenitis. Diagnostic molecular pathology","volume":"7","author":"Sumiyoshi, Y.; Kikuchi, M.; Ohshima, K.","unstructured":"Sumiyoshi Y, Kikuchi M, Ohshima K, et al. Human herpesvirus-6 lymphadenitis. Diagnostic molecular pathology. Am J7 Surg Pathol (in press).","journal-title":"Am"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1056\/NEJM199307153290304","article-title":"Severe infectious mononucleosis-like syndrome and a primary human herpesvirus-6 infection in an adult","volume":"329","author":"Akashi, K.; Eizuru, Y.; Sumiyoshi, Y.","year":"1993","unstructured":"Akashi K, Eizuru Y, Sumiyoshi Y, et al. Severe infectious mononucleosis-like syndrome and a primary human herpesvirus-6 infection in an adult. N Engl J Med 1993;329:168-71.","journal-title":"N Engl J Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0042-6822(90)90033-N","article-title":"Analysis of a glycoprotein of human herpesvirus-6 (HHV-6) using monoclonal antibodies","volume":"176","author":"Okuno, T.; Sao, H.; Asada, H.","year":"1990","unstructured":"Okuno T, Sao H, Asada H, et al. Analysis of a glycoprotein of human herpesvirus-6 (HHV-6) using monoclonal antibodies. Virology 1990;176:625-8.","journal-title":"Virology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/ajcp\/99.5.609","article-title":"Human herpesvirus-6 genomes in histiocytic necrotizing lymphadenitis (Kikuchi's disease) and other forms of lymphadenitis","volume":"99","author":"Sumiyoshi, Y.; Kikuchi, M.; Ohshima, K.","year":"1993","unstructured":"Sumiyoshi Y, Kikuchi M, Ohshima K, et al. Human herpesvirus-6 genomes in histiocytic necrotizing lymphadenitis (Kikuchi's disease) and other forms of lymphadenitis. Am GClin Pathol 1993;99:609-14.","journal-title":"Am GClin Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.47.8.762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:53:10Z","timestamp":1765075990000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.47.8.762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":7,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1994,8,1]]},"published-print":{"date-parts":[[1994,8]]}},"alternative-id":["10.1136\/jcp.47.8.762"],"URL":"https:\/\/doi.org\/10.1136\/jcp.47.8.762","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}