{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:31:26Z","timestamp":1770219086571,"version":"3.49.0"},"reference-count":17,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>AIM--To evaluate the histological changes that occur in the antral mucosa of healthy male subjects before and after one week of naproxen administration, using a chemical gastritis score according to the Helicobacter pylori status. METHODS--Nineteen male subjects (mean age 31 years) underwent two endoscopies: one before and the other after one week of naproxen treatment (1 g daily). Antral biopsy specimens were assessed for the presence of H pylori infection and for chemical gastritis, defined as the presence of foveolar hyperplasia, muscle fibres in the lamina propria, oedema, and vasodilatation, in the absence of acute or chronic inflammatory cell infiltrate. RESULTS--Of the 19 subjects, eight had H pylori infection. After one week of naproxen treatment, none of those with H pylori infection developed chemical gastritis, while five of 11 (45%) of those without H pylori infection did. In the absence of H pylori infection there was no evidence of inflammation, either before or after naproxen administration. CONCLUSIONS--A different pattern of antral histological change occurs following naproxen administration. This pattern is related to the presence or absence of H pylori infection, suggesting that H pylori status should be determined in histological studies of subjects taking non-steroidal anti-inflammatory drugs.<\/jats:p>","DOI":"10.1136\/jcp.48.1.61","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"61-63","source":"Crossref","is-referenced-by-count":6,"title":["Chemical gastritis induced by naproxen in the absence of Helicobacter pylori infection."],"prefix":"10.1136","volume":"48","author":[{"given":"C J","family":"McCarthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Hourihane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"O'Morain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/rheumatology\/30.1.16","article-title":"Serological evidence of infection with Helicobacter pylori may predict gastrointestinal intolerance to non-steroidal anti-inflammatory drug treatment of rheumatoid arthritis","volume":"30","author":"Jones, S.T.M.; Clague, R.B.; Eldridge, J.; Jones, D.M.","year":"1991","unstructured":"Jones STM, Clague RB, Eldridge J, Jones DM. 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BrJ Rheumatol 1988; 27:113-16.","journal-title":"BrJ Rheumatol"},{"key":"ref_3","first-page":"135","article-title":"Chemical gastritis and Helicobacter pylori related gastritis in patients receiving non-steroidal anti-inflammatory drugs: comparison and correlation with peptic ulceration","volume":"45","author":"Taha, A.S.; Nakshabendi, I.; Lee, F.D.; Sturrock, R.D.; Russell, R.I.","year":"1992","unstructured":"Taha AS, Nakshabendi I, Lee FD, Sturrock RD, Russell RI. 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Am Jf Gastroenterol 1991;86:735-7.","journal-title":"Am Jf Gastroenterol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/0016-5085(91)90665-8","article-title":"Long-term nonsteroidal anti-inflammatory drug use and Helicobacter pylon infection","volume":"100","author":"Graham, D.Y.; Lidsky, M.D.; Cox, A.M.; DJ, Jr, Evans; Evans, D.G.; Alpert, L.","year":"1991","unstructured":"Graham DY, Lidsky MD, Cox AM, Evans DJ Jr, Evans DG, Alpert L, et al. Long-term nonsteroidal anti-inflammatory drug use and Helicobacter pylon infection. Gastroenterology 1991;100: 1653-7.","journal-title":"Gastroenterology"},{"key":"ref_6","first-page":"1185","article-title":"Relationship between Campylobacterpylori and gastritis in healthy humans after the administration of placebo","volume-title":"or indomethacin Gastroenterology 1988; 95","author":"Peterson, W.L.; Lee, E.; Feldman, M.","unstructured":"Peterson WL, Lee E, Feldman M. 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Gastroenterology 1992; 102","author":"Loeb, D.S.; Talley, N.J.; Ahlquist, D.A.; Carpenter, H.A.; Zinsmeister, A.R.","unstructured":"Loeb DS, Talley NJ, Ahlquist DA, Carpenter HA, Zinsmeister AR. Long term use of nonsteroidal antiinflammatory drugs and gastroduodenal injury; the role of Helicobacter pylori. 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