{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:37:24Z","timestamp":1765039044751,"version":"3.46.0"},"reference-count":28,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:p>AIMS--To define and group static and dynamic iliac crest histomorphometric parameters in women with established osteoporosis. METHODS--Iliac crest biopsy specimens from 146 white women were sectioned undecalcified and examined using image analysis. RESULTS--Five distinct groups were defined on the basis of histomorphometric changes in cell function: group 1, decreased osteoblastic and osteoclastic activity; group 2, decreased osteoblastic and increased osteoclastic activity; group 3, increased osteoblastic and osteoclastic activity; group 4, no bone surface cell activity; and group 5, apparently normal osteoblastic and osteoclastic activity. CONCLUSIONS--Five distinct subgroups of patients with postmenopausal osteoporosis can be defined based on changes in bone cell function. Defining cellular dysfunction in this way may be important for tailoring treatment regimens to the needs of individual patients.<\/jats:p>","DOI":"10.1136\/jcp.48.3.229","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"229-235","source":"Crossref","is-referenced-by-count":13,"title":["Histomorphometric classification of postmenopausal osteoporosis: implications for the management of osteoporosis."],"prefix":"10.1136","volume":"48","author":[{"given":"M T","family":"Rehman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Hoyland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Denton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Freemont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF02555743","article-title":"The role of serum concentration of sex steroids and bone turnover in the development and occurrence of postmenopausal osteoporosis","volume":"38","year":"1986","unstructured":"Riis BJ, Rodbro 0, Christiensen C. The role of serum concentration of sex steroids and bone turnover in the development and occurrence of postmenopausal osteoporosis. Calcific Tissue Int 1986;38:318-22.","journal-title":"Calcific Tissue Int"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/jbmr.5650050402","article-title":"Cancellous bone remodelling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels","volume":"5","author":"Eriksen, E.F.; Hodgson, S.F.; Eastell, R.; Cedal, S.L.; O'Fallon, W.M.; Riggs, B.L.","year":"1990","unstructured":"Eriksen EF, Hodgson SF, Eastell R, Cedal SL, O'Fallon WM, Riggs BL. 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