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A case is reported of a 42 year old woman with a history of menorrhagia in whom a combination of degenerative and iatrogenic changes resulted in a histological appearance resembling diffuse leiomyomatosis.<\/jats:p>","DOI":"10.1136\/jcp.48.3.278","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"278-280","source":"Crossref","is-referenced-by-count":3,"title":["Degenerative changes in myometrium simulating diffuse leiomyomatosis after treatment with gonadotrophin releasing hormone analogue."],"prefix":"10.1136","volume":"48","author":[{"given":"M","family":"Jeffers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C B","family":"Lunan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0046-8177(93)90186-K","article-title":"The histopathology of uterine leiomyomas following treatment with gonadotrophin releasing hormone analogues","volume":"24","author":"Colgan, T.J.; Pendergast, S.; LeBlanc, M.","year":"1993","unstructured":"Colgan TJ, Pendergast S, LeBlanc M. The histopathology of uterine leiomyomas following treatment with gonadotrophin releasing hormone analogues. Hum Pathol 1993; 24:1073-7.","journal-title":"Hum Pathol"},{"issue":"811 -14","key":"ref_2","article-title":"Histopathological changes in leiomyomata treated with leuprolide acetate","volume":"54","author":"Upadhyaya, N.B.; Doody, M.C.; Googe, P.B.","year":"1990","unstructured":"Upadhyaya NB, Doody MC, Googe PB. Histopathological changes in leiomyomata treated with leuprolide acetate. Fertil Steril 1990;54:811 -14.","journal-title":"Fertil Steril"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0015-0282(16)60806-3","article-title":"Vaginal hemorrhage associated with degenerating submucous leiomyomata during leuprolide acetate treatment","volume":"52","author":"Friedman, A.J.","year":"1989","unstructured":"Friedman AJ. Vaginal hemorrhage associated with degenerating submucous leiomyomata during leuprolide acetate treatment. Fertil Steril 1989;52:152-4.","journal-title":"Fertil Steril"},{"key":"ref_4","first-page":"1018","article-title":"Fibroid and myometrial steroid receptors in women treated with gonadotrophin-releasing hormone agonist leuprolide acetate","volume-title":"Fertil Steil","volume":"53","author":"Rein, M.S.; Friedman, A.J.; Stuart, J.M.; MacLaughlin, D.T.","year":"1990","unstructured":"Rein MS, Friedman AJ, Stuart JM, MacLaughlin DT. Fibroid and myometrial steroid receptors in women treated with gonadotrophin-releasing hormone agonist leuprolide acetate. Fertil Steil 1990;53: 1018-23."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0015-0282(16)59464-3","article-title":"Treatment of leiomyomata with intranasal or subcutaneous leuprolide, a gonadotrophin-releasing hormone agonist","volume":"48","author":"Friedman, A.J.; Barbieri, R.L.; Benacerraf, B.R.; Schiff, I.","year":"1987","unstructured":"Friedman AJ, Barbieri RL, Benacerraf BR, Schiff I. Treatment of leiomyomata with intranasal or subcutaneous leuprolide, a gonadotrophin-releasing hormone agonist. Fertil Seril 1987;48:560-4.","journal-title":"Fertil Seril"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00000478-199201000-00004","article-title":"Diffuse, perinodular and other patterns of hydropic degeneration within and adjacent to uterine leiomyomas","volume":"16","author":"Clement, P.B.; Young, R.H.; Scully, R.E.","year":"1992","unstructured":"Clement PB, Young RH, Scully RE. Diffuse, perinodular and other patterns of hydropic degeneration within and adjacent to uterine leiomyomas. Am Surg Pathol 1992;16:26-32.","journal-title":"Am Surg Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.48.3.278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:55:04Z","timestamp":1765691704000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.48.3.278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1995,3,1]]},"published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1136\/jcp.48.3.278"],"URL":"https:\/\/doi.org\/10.1136\/jcp.48.3.278","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}