{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:38:24Z","timestamp":1790617104160,"version":"4.1.0"},"reference-count":23,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:p>AIMS--To analyse the diagnostic value of cytological examination compared with histological findings in a large series of patients (n = 615) with tumours of the urinary tract epithelium. METHODS--Cytological examinations (n = 785) after bladder washing and exfoliative cytology were retrospectively compared and correlated with histological findings. In addition, 1527 bladder washings were obtained during follow up of patients after transurethral resection of bladder tumours. RESULTS--Cytology in bladder washings (overall diagnostic accuracy 66%) provides considerably more information that exfoliative cytology (overall accuracy 49%). Cytological examinations (n = 1125) in patients with bladder tumours receiving intravesical cytostatic drugs (for example, mitomycin C) yielded suspicious or positive results in 28% of patients, without being confirmed by endoscopy during follow up. CONCLUSION--Our results illustrate two major drawbacks of urinary cytology. First, a high rate of false positive results in patients on intravesical chemotherapy. Second, a high rate of false negative results in highly differentiated carcinomas, stressing the need for additional diagnostic tests such as staining with monoclonal antibodies directed against tumour antigens or assessment of ploidy.<\/jats:p>","DOI":"10.1136\/jcp.48.4.314","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"314-317","source":"Crossref","is-referenced-by-count":59,"title":["The clinical value of urinary cytology: 12 years of experience with 615 patients."],"prefix":"10.1136","volume":"48","author":[{"given":"U","family":"Maier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Simak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Neuhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1995,4,1]]},"reference":[{"issue":"49","key":"ref_1","first-page":"1","volume":"1856","author":"Vierteljahresschr, Lambl V.O.Prager","unstructured":"Lambl VO. 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A preliminary report","volume":"16","author":"Reichborn-Kjennerud, S.; Hoeg, K.","year":"1972","unstructured":"Reichborn-Kjennerud S, Hoeg K. The value of urinary cytology in the diagnosis of recurrent bladder tumours. A preliminary report. Acta Cytol 1972;16:269-72.","journal-title":"Acta Cytol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0022-5347(17)61391-0","article-title":"Urinary cytology and the clinical diagnosis of urinary tract malignancy. A clinicopathological study of 1,400 patients","volume":"106","author":"Sarnacki, C.T.; McCormack, U.; Kiser, W.S.; Beach Hazard, J.; McLaughlin, T.C.; Belovich, D.M.","year":"1971","unstructured":"Sarnacki CT, McCormack U, Kiser WS, Beach Hazard J, McLaughlin TC, Belovich DM. Urinary cytology and the clinical diagnosis of urinary tract malignancy. A clinicopathological study of 1,400 patients. 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Cytology in the diagnosis and follow up of transitional cell carcinoma of the urothelium: a review with a case series. Urol 1976;116:43-6.","journal-title":"Urol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/1097-0142(19871001)60:7<1423::AID-CNCR2820600702>3.0.CO;2-6","article-title":"The sensitivity of bladder wash flow cytometry, bladder wash cytology, and voided cytology in the detection of bladder carcinoma","volume":"60","author":"Badalament, R.A.; Hermansen, D.K.; Kimmel, M.; Gay, H.; Herr, H.W.; Fair, W.R.","year":"1987","unstructured":"Badalament RA, Hermansen DK, Kimmel M, Gay H, Herr HW, Fair WR, et al. The sensitivity of bladder wash flow cytometry, bladder wash cytology, and voided cytology in the detection of bladder carcinoma. Cancer 1987;60: 1423-7.","journal-title":"Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0022-5347(17)49814-4","article-title":"Evaluation of bladder washings and urine cytology in the diagnosis of bladder cancer and its correlation with selected biopsies of the bladder mucosa","volume":"132","author":"Zein, T.; Wajsman, Z.; Englander, L.S.; Gamarra, M.; Lopez, C.; Huben, R.P.","year":"1984","unstructured":"Zein T, Wajsman Z, Englander LS, Gamarra M, Lopez C, Huben RP, et al. Evaluation of bladder washings and urine cytology in the diagnosis of bladder cancer and its correlation with selected biopsies of the bladder mucosa. J Urol 1984;132:670-1.","journal-title":"J Urol"},{"key":"ref_14","first-page":"145","article-title":"Critical appraisal of tumor markers in bladder cancer","volume":"XI:","author":"Fradet, Y.; Cordon-Cardo, C.","year":"1993","unstructured":"Fradet Y, Cordon-Cardo C. Critical appraisal of tumor markers in bladder cancer. Semin Urol 1993;XI:145-53.","journal-title":"Semin Urol"},{"key":"ref_15","first-page":"13","article-title":"DNA profile and tumour progression in patients with superficial bladder tumors","volume":"10","author":"Gustafson, H.; Tribukait, B.; Esposti, P.L.","year":"1982","unstructured":"Gustafson H, Tribukait B, Esposti PL. DNA profile and tumour progression in patients with superficial bladder tumors. UrolRes 1982;10:13-18.","journal-title":"UrolRes"},{"key":"ref_16","first-page":"\"1155","article-title":"Kaalhus 0, Scott-Knudsen 0. The clinical and histopathological significance of Feulgen DNA values in transitional cell carcinoma of the human urinary bladder","volume":"13","author":"Fossa, S.D.","year":"1977","unstructured":"Fossa SD, Kaalhus 0, Scott-Knudsen 0. The clinical and histopathological significance of Feulgen DNA values in transitional cell carcinoma of the human urinary bladder. Eur J Cancer 1977;13:1155-7. 17 deVere White RW, Deitch AD, West B, Fitzpatrick JM. The predictive value of flow cytometric information in the clinical management of stage 0 (Ta) bladder cancer. J Urol 1988;139:279-82.","journal-title":"Eur J Cancer; The predictive value of flow cytometric information in the clinical management of stage 0 (Ta) bladder cancer"},{"key":"ref_17","first-page":"459","article-title":"Stellenwert der Urotheldysplasie im Rahmen des Blasenmappings","volume":"52","author":"Maier, U.; Holzner, J.H.","year":"1985","unstructured":"Maier U, Holzner JH. Stellenwert der Urotheldysplasie im Rahmen des Blasenmappings. Helv Chir Acta 1985;52: 459-62.","journal-title":"Helv Chir Acta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000471673","article-title":"Value of bladder wash cytology in the follow up of patients with bladder carcinoma receiving intravesical chemoprophylaxis with mitomycin C","volume":"20","author":"Hobarth, K.; Maier, U.; Susani, M.","year":"1991","unstructured":"Hobarth K, Maier U, Susani M. Value of bladder wash cytology in the follow up of patients with bladder carcinoma receiving intravesical chemoprophylaxis with mitomycin C. Eur J Urol 1991;20:93-6.","journal-title":"Eur J Urol"},{"key":"ref_19","first-page":"232","article-title":"Stellenwert der Urotheldysplasie in makroskopisch normaler Schleimhaut bei Patienten mit Blasentumoren. Ergebnisse einer randomisierten Studie mit und ohne intravesicale Mitomycin C-Rezidivprophylaxe","volume":"8","author":"Maier, U.; Holzner, J.H.","year":"1985","unstructured":"Maier U, Holzner JH. Stellenwert der Urotheldysplasie in makroskopisch normaler Schleimhaut bei Patienten mit Blasentumoren. Ergebnisse einer randomisierten Studie mit und ohne intravesicale Mitomycin C-Rezidivprophylaxe. Onkologie 1985;8:232-40.","journal-title":"Onkologie"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0022-5347(17)38157-0","article-title":"Identification of a high risk subgroup of grade 1 transitional cell carcinoma using image analysis based deoxyribonucleic acid ploidy analysis of tumor tissue","volume":"146","author":"m, Hemstreet G.P.; S, Rollins; P, Jones; JY, Rao; RE, Hurst; R, Bass Bonner","year":"1991","unstructured":"Hemstreet GP m, Rollins S, Jones P, Rao JY, Hurst RE, Bass Bonner R, et al. Identification of a high risk subgroup of grade 1 transitional cell carcinoma using image analysis based deoxyribonucleic acid ploidy analysis of tumor tissue. 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The morphologic effects of mitomycin C in mammalian urinary bladder. Cancer 1981;47:2567-74.","journal-title":"Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000471723","article-title":"Intratumoral heterogeneity of DNA indices in transitional cell bladder cancer: Relation to tumour histology","volume":"20","author":"Lipponen, P.K.; Eskelinen, M.J.; Nordling, S.","year":"1991","unstructured":"Lipponen PK, Eskelinen MJ, Nordling S. Intratumoral heterogeneity of DNA indices in transitional cell bladder cancer: Relation to tumour histology. 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