{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:04:56Z","timestamp":1770505496381,"version":"3.49.0"},"reference-count":7,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:p>A case of fatal Epstein-Barr virus (EBV) associated lymphoproliferative disorder is reported in an 11 month old female. Heavy infiltrates of CD20 + and EBV EBER mRNA expressing lymphoid blasts were found to cause a series of ulcers along the entire length of the gastrointestinal tract and there was an ileal perforation. Similar infiltrates were also found in lymph nodes, spleen, and liver. Although blood phenotypic analysis performed shortly before her death revealed a severe decrease in T lymphocytes, neither the patient nor other members of her family had a history of primary or secondary immunodeficiency. EBV infection is common in children. However, such a fatal infection of the virus has not apparently been described previously in infants without pre-established immunodeficiency.<\/jats:p>","DOI":"10.1136\/jcp.48.4.390","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"390-392","source":"Crossref","is-referenced-by-count":11,"title":["Epstein-Barr virus associated lymphoproliferative disorder with fatal involvement of the gastrointestinal tract in an infant."],"prefix":"10.1136","volume":"48","author":[{"given":"L X","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Ramani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T C","family":"Diss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L N","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Isaacson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/BF01959075","article-title":"Epstein-Barr virus infection and associated diseases in children. 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Pathol 1993;169:291-5.","journal-title":"Pathol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0140-6736(91)91837-K","article-title":"Epstein-Barr virus in AIDS-related primary central nervous system lymphoma","volume":"338","author":"MacMahon, E.M.; Glass, J.D.; Hayward, S.D.; Mann, R.B.; Becker, P.S.; Charache, P.","year":"1991","unstructured":"MacMahon EM, Glass JD, Hayward SD, Mann RB, Becker PS, Charache P, et al. Epstein-Barr virus in AIDS-related primary central nervous system lymphoma. Lancet 1991; 338:969-73.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/BF01957926","article-title":"Epstein-Barr virus infection and associated diseases in children. H. Diagnostic and therapeutic strategies","volume":"151","author":"Schuster, V.; Kreth, H.W.","year":"1992","unstructured":"Schuster V, Kreth HW. Epstein-Barr virus infection and associated diseases in children. H. Diagnostic and therapeutic strategies. EurJ Pediatr 1992;151:794-8.","journal-title":"EurJ Pediatr"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/0046-8177(93)90195-M","article-title":"et al A case of fatal infectious mononucleosis presenting with fulminant hepatic failure associated with an extensive CD8-positive lymphocyte infiltration in the liver","volume":"24","author":"Tazawa, Y.; Nishinomiya, F.; Noguchi, H.; Takada, G.; Tsuchiya, S.; Sumazaki, R.","year":"1993","unstructured":"Tazawa Y, Nishinomiya F, Noguchi H, Takada G, Tsuchiya S, Sumazaki R, et al A case of fatal infectious mononucleosis presenting with fulminant hepatic failure associated with an extensive CD8-positive lymphocyte infiltration in the liver. Hum Pathol 1993;24:1135-9.","journal-title":"Hum Pathol"},{"key":"ref_7","first-page":"372","article-title":"Immunodeficiency disorders","author":"Abramowsky, C.","year":"1992","unstructured":"Abramowsky C. Immunodeficiency disorders. In: StockerJT, Dehner LP, eds. Pediatric pathology, Vol I. Philadelphia: Lippincott, 1992:372-4."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.48.4.390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:46:19Z","timestamp":1765701979000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.48.4.390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1995,4,1]]},"published-print":{"date-parts":[[1995,4]]}},"alternative-id":["10.1136\/jcp.48.4.390"],"URL":"https:\/\/doi.org\/10.1136\/jcp.48.4.390","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4]]}}}