{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:42:23Z","timestamp":1791470543332,"version":"4.3.4"},"reference-count":31,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>AIM--To examine the expression of HLA-ABC and HLA-DR major histocompatibility (MHC) antigens and intercellular adhesion molecule (ICAM)-1 in normal, inflamed, metaplastic, and neoplastic oesophageal tissue and in freshly disaggregated tumours. METHODS--Sequential sections of frozen tissue and cytospins of freshly disaggregated tumour were stained using the ABC peroxidase system and monoclonal antibodies specific for HLA-ABC, HLA-DR and ICAM-1. RESULTS--Normal oesophageal tissue showed positive staining for HLA-ABC in the basal layers of the oesophageal squamous epithelium and on the epithelial cells of the submucosal oesophageal glands. HLA-DR and ICAM-1 were not detected in either of these cell types. In 20 of 37 (54%) carcinomas HLA-ABC was expressed weakly, with heterogeneous expression in nine (24%). Two tumours showed strong expression of HLA-ABC, but 15 of 37 (41%) were negative. HLA-DR and ICAM-1 were expressed weakly in six of 37 (16%) carcinomas without correlation with each other or with the expression of HLA-ABC. CONCLUSIONS--HLA-ABC is absent from a high proportion of oesophageal carcinomas (41%) and is otherwise variably and weakly expressed with strong expression in only a small fraction (3%). In other carcinomas there is a higher level of HLA-ABC expression. This discrepancy may partly explain the aggressive nature of oesophageal carcinomas. HLA-DR and ICAM-1 are not normally expressed on those cells from which oesophageal carcinomas are thought to arise. The limited expression found here could suggest a partial or inhibited immune response against oesophageal carcinoma. In vivo repressive factors may be involved.<\/jats:p>","DOI":"10.1136\/jcp.48.6.539","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"539-544","source":"Crossref","is-referenced-by-count":29,"title":["Expression of HLA-ABC, HLA-DR and intercellular adhesion molecule-1 in oesophageal carcinoma."],"prefix":"10.1136","volume":"48","author":[{"given":"J C","family":"Rockett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Darnton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Crocker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H R","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A G","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0065-2776(08)60262-X","article-title":"MHC-restricted cytotoxic Tcells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restrictionspecificity, function and responsiveness","volume":"27","author":"Zinkernagel, R.; Doherty, P.","year":"1979","unstructured":"Zinkernagel R, Doherty P. MHC-restricted cytotoxic Tcells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restrictionspecificity, function and responsiveness. Adv Immunol 1979;27:51-177.","journal-title":"Adv Immunol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000420682","article-title":"The role of ICAM-1 in tumour development","volume":"50","author":"Johnson, J.P.","year":"1991","unstructured":"Johnson JP. The role of ICAM-1 in tumour development [review]. Chem Immunol 1991;50:143-63.","journal-title":"Chem Immunol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/00007890-198409000-00018","article-title":"The detailed distribution of HLA-ABC antigens in normal human organs","volume":"38","author":"Darr, A.S.; Fuggle, S.V.; Fabre, J.W.; Ting, A.; Morris, P.J.","year":"1984","unstructured":"Darr AS, Fuggle SV, Fabre JW, Ting A, Morris PJ. The detailed distribution of HLA-ABC antigens in normal human organs. Transplantation 1984;38:287-92.","journal-title":"Transplantation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/jcp.34.7.779","article-title":"Distribution of class I antigens in normal and in mammary cancer","volume":"34","author":"Fleming, K.A.; McMichael, A.; Morton, J.A.; Woods, J.; JO'D, McGee","year":"1981","unstructured":"Fleming KA, McMichael A, Morton JA, Woods J, McGee JO'D. Distribution of class I antigens in normal and in mammary cancer. J Clin Pathol 1981;34:779-84.","journal-title":"J Clin Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/bjc.1989.45","article-title":"HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens in colorectal, gastric and laryngeal carcinomas","volume":"59","author":"Lopez-Nevot, M.A.; Esteban, F.; Ferron, A.; Gutierrez, J.; Oliva, M.R.; Romero, C.","year":"1989","unstructured":"Lopez-Nevot MA, Esteban F, Ferron A, Gutierrez J, Oliva MR, Romero C, et al. HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens in colorectal, gastric and laryngeal carcinomas. BrJ Cancer 1989; 59:221-6.","journal-title":"BrJ Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/ijc.2910460614","article-title":"Loss of MHC class I expression in cervical carcinomas","volume":"46","author":"Connor, M.E.; Stern, P.L.","year":"1990","unstructured":"Connor ME, Stern PL. Loss of MHC class I expression in cervical carcinomas. Int J Cancer 1990;46:1029-34.","journal-title":"Int J Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/bjc.1990.437","article-title":"MHC class I antigens and tumour aggressiveness of the squamous cell carcinoma of the larynx","volume":"62","author":"Esteban, F.; Concha, A.; Delgado, M.; Perez-Ayala, M.; RuizCabello, F.; Garrido, F.","year":"1990","unstructured":"Esteban F, Concha A, Delgado M, Perez-Ayala M, RuizCabello F, Garrido F. MHC class I antigens and tumour aggressiveness of the squamous cell carcinoma of the larynx. Br J Cancer 1990;62:1047-51.","journal-title":"Br J Cancer"},{"key":"ref_8","first-page":"146","article-title":"Can the HLA phenotype be used as a prognostic factor in breast carcinomas","volume":"6","author":"Concha, A.; Cabrera, T.; Ruiz-Cabello, F.; Garrido, F.","year":"1991","unstructured":"Concha A, Cabrera T, Ruiz-Cabello F, Garrido F. Can the HLA phenotype be used as a prognostic factor in breast carcinomas. Int J Cancer 1991;Suppl 6:146-54.","journal-title":"Int J Cancer"},{"key":"ref_9","first-page":"4948","article-title":"Expression of HLA class I and II antigens in bronchogenic carcinomas: Its relationship to cellular DNA content and clinical-pathological parameters","volume":"51","author":"Redondo, M.; Concha, A.; Oldiviela, R.; Cueto, A.; Gonzalez, F.; Garrido, F.","year":"1991","unstructured":"Redondo M, Concha A, Oldiviela R, Cueto A, Gonzalez F, Garrido F, et al. Expression of HLA class I and II antigens in bronchogenic carcinomas: Its relationship to cellular DNA content and clinical-pathological parameters. Cancer Res 1991;51:4948-54.","journal-title":"Cancer Res"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0171-2985(11)80086-0","article-title":"HLA molecules in basal-cell carcinoma of the skin","volume":"185","author":"Cabrera, T.; Garrido, V.; Concha, A.; Martin, J.; Esquivias, J.; Oliva, M.R.","year":"1992","unstructured":"Cabrera T, Garrido V, Concha A, Martin J, Esquivias J, Oliva MR, et al. HLA molecules in basal-cell carcinoma of the skin. Immunobiology 1992;185:440-52.","journal-title":"Immunobiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00007890-198409000-00019","article-title":"The detailed distribution of class II antigens in normal human organs","volume":"38","author":"Daar, A.S.; Fuggle, S.V.; Fabre, J.W.; Ting, A.; Morris, P.J.","year":"1984","unstructured":"Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ. The detailed distribution of class II antigens in normal human organs. Transplantation 1984;38:293-8.","journal-title":"Transplantation"},{"key":"ref_12","first-page":"389","article-title":"Tissue distribution of class II transplantation antigens: presence on normal cells","volume":"21","author":"Klareskog, L.; Forsum, U.","year":"1984","unstructured":"Klareskog L, Forsum U. Tissue distribution of class II transplantation antigens: presence on normal cells. Scand J Immunol 1984;21:389-96.","journal-title":"Scand J Immunol"},{"key":"ref_13","first-page":"614","article-title":"Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease","volume":"53","author":"Selby, W.S.; Janossy, G.; Mason, D.Y.; Jewell, D.P.","year":"1983","unstructured":"Selby WS, Janossy G, Mason DY, Jewell DP. Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. Clin Exp Immunol 1983;53:614-18.","journal-title":"Clin Exp Immunol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-3083.1983.tb00833.x","article-title":"T-lymphocyte subsets and HLA expressing cells in rejected human kidney grafts","volume":"18","author":"Tufvesson, G.; Forsum, U.; Claesson, K.; Klareskog, L.; Larsson, E.; Karlsson-Parra, A.","year":"1983","unstructured":"Tufvesson G, Forsum U, Claesson K, Klareskog L, Larsson E, Karlsson-Parra A, et al. 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Rheumatoid arthritis: a disease of T lymphocyte and macrophage immunoregulation. Lancet 1981;ii:839-43.","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-3083.1981.tb00198.x","article-title":"Appearance of anti-HLA-DR reactive cells in normal and rheumatoid synovium","volume":"14","author":"Klareskog, L.; Forsum, U.; Malmnas Tjernlund, U.; Kabelitz, D.; Wigren, A.","year":"1981","unstructured":"Klareskog L, Forsum U, Malmnas Tjernlund U, Kabelitz D, Wigren A. Appearance of anti-HLA-DR reactive cells in normal and rheumatoid synovium. Scand Immunol 1981;14: 183-92.","journal-title":"Scand Immunol"},{"key":"ref_18","first-page":"4009","article-title":"HIA class II antigen expression in human papillomavirus-associated cervical cancer","volume":"52","author":"Glew, S.S.; Duggan Keen, M.; Cabrera, T.; Stern, P.L.","year":"1992","unstructured":"Glew SS, Duggan Keen M, Cabrera T, Stern PL. HIA class II antigen expression in human papillomavirus-associated cervical cancer. Cancer Res 1992;52:4009-16.","journal-title":"Cancer Res"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/bjc.1984.239","article-title":"Distribution of histocompatibility and leukocyte differentation antigens in normal human colon and in benign and malignant colonic neoplasms","volume":"50","author":"Csiba, A.; Whitwell, H.L.; Moore, M.","year":"1984","unstructured":"Csiba A, Whitwell HL, Moore M. Distribution of histocompatibility and leukocyte differentation antigens in normal human colon and in benign and malignant colonic neoplasms. Br Cancer 1984;50:699-709.","journal-title":"Br Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/ijc.2910540413","article-title":"Estimates of the worldwide incidence of eighteen major cancers in 1985","volume":"54","author":"Parkin, D.M.; Pisani, P.; Ferlay, J.","year":"1993","unstructured":"Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. IntJI Cancer 1993;54:594-606.","journal-title":"IntJI Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/bjc.1992.124","article-title":"Oesophageal mortality in Europe: paradoxical time trend in relation to smoking and drinking","volume":"65","author":"Cheng, K.K.; Day, N.E.; Davies, T.W.","year":"1992","unstructured":"Cheng KK, Day NE, Davies TW. Oesophageal mortality in Europe: paradoxical time trend in relation to smoking and drinking. Br I Cancer 1992;65:613-17.","journal-title":"Br I Cancer"},{"key":"ref_22","first-page":"114","article-title":"JE (eds). Cancer of the oesophagus. In: Clinical cancer monographs. Vol 1","author":"Matthews, H.R.; Waterhouse, J.A.H.; Powell, J.; McConkey, C.C.; Robertson","year":"1993","unstructured":"Matthews HR, Waterhouse JAH, Powell J, McConkey CC, Robertson JE (eds). Cancer of the oesophagus. In: Clinical cancer monographs. Vol 1. London: Macmillan, 1993:114-65."},{"key":"ref_23","first-page":"42","article-title":"LH (eds). UICC TNM classification of malignant tumours","author":"Hermanek, P.; Sobin","year":"1992","unstructured":"Hermanek P, Sobin LH (eds). UICC TNM classification of malignant tumours. 4th edn, 2nd revision. Berlin: SpringerVerlag, 1992:42-4.","edition":"4th edn,"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0167-5699(93)90264-L","article-title":"Natural history of HIA expression during tumour development","volume":"14","author":"Garrido, F.; Cabrera, T.; Concha, A.; Glew, S.; Ruiz-Cabello, F.; Stern, P.L.","year":"1993","unstructured":"Garrido F, Cabrera T, Concha A, Glew S, Ruiz-Cabello F, Stern PL. Natural history of HIA expression during tumour development. Immunol Today 1993;14:491-9.","journal-title":"Immunol Today"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0167-5699(91)90096-C","article-title":"Antigen presentation: structural themes and functional variations","volume":"12","author":"Braciale, T.J.; Braciale, V.L.","year":"1991","unstructured":"Braciale TJ, Braciale VL. Antigen presentation: structural themes and functional variations. Immunol Today 1991; 12:124-9.","journal-title":"Immunol Today"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-3083.1991.tb01531.x","article-title":"Loss of HLA heavy chain and beta-2-microglobulin in HLA negative tumours","volume":"34","author":"Cabrera, T.; Concha, A.; Ruiz-Cabello, F.; Garrido, F.","year":"1991","unstructured":"Cabrera T, Concha A, Ruiz-Cabello F, Garrido F. Loss of HLA heavy chain and beta-2-microglobulin in HLA negative tumours. Scand _J Immunol 1991;34:147-52.","journal-title":"Scand _J Immunol"},{"key":"ref_27","first-page":"233","article-title":"Relationship between HLA-DR-like antigens and secretory component (SC) in jejunal epithelium of patients with coelic disease or dermatitis herpetiformis. Clin Exp Immunol","volume":"44","author":"Scott, H.; Brandtzaeg, P.; Solheim, B.G.; Thorsby, E.","year":"1981","unstructured":"Scott H, Brandtzaeg P, Solheim BG, Thorsby E. Relationship between HLA-DR-like antigens and secretory component (SC) in jejunal epithelium of patients with coelic disease or dermatitis herpetiformis. Clin Exp Immunol 1981;44:233-8."},{"key":"ref_28","first-page":"641","article-title":"De novo expression of intercellular adhesion molecule in melanoma correlated with increased","volume-title":"risk of metastasis. Proc Natl Acad Sci","volume":"86","author":"Johnson, J.P.; Stade, B.G.; Holzmann, B.; Schwable, W.; Reithmuller, G.","year":"1989","unstructured":"Johnson JP, Stade BG, Holzmann B, Schwable W, Reithmuller G. De novo expression of intercellular adhesion molecule in melanoma correlated with increased risk of metastasis. Proc Natl Acad Sci USA 1989;86:641-4."},{"key":"ref_29","first-page":"2980","article-title":"Modulation by interferons of HLA antigen, high molecular weight melanoma-associated antigens and intercellular adhesion molecule 1 expression by cultured melanoma cells with different metastatic potential","volume":"49","author":"Maio, M.; Gulwani, B.; Langer, A.; Kerbel, R.S.; Duigou, G.J.; Fisher, P.B.","year":"1990","unstructured":"Maio M, Gulwani B, Langer A, Kerbel RS, Duigou GJ, Fisher PB, et al. Modulation by interferons of HLA antigen, high molecular weight melanoma-associated antigens and intercellular adhesion molecule 1 expression by cultured melanoma cells with different metastatic potential. Cancer Res 1990;49:2980-7.","journal-title":"Cancer Res"},{"key":"ref_30","first-page":"1271","article-title":"Differential expression of intercellular adhesion molecule-l in primary and metastatic melanoma lesions","volume":"50","author":"Natali, P.; Nicotra, M.R.; Caviere, R.; Biotti, A.; Romano, G.; Temponi, M.","year":"1990","unstructured":"Natali P, Nicotra MR, Caviere R, Biotti A, Romano G, Temponi M, et al. Differential expression of intercellular adhesion molecule-l in primary and metastatic melanoma lesions. Cancer Res 1990;50:1271-8.","journal-title":"Cancer Res"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/ijc.2910430504","article-title":"Expression of 7f7antigen, a human adhesion molecule identical to intercellular adhesion molecule 1 (ICAM-1) in human carcinomas and their stromal fibroblasts","volume":"43","author":"Vogetseder, W.; Feichtinger, H.; Schulz, T.F.; Schwaeble, W.; Tabaczewski, P.; Mitterer, M.","year":"1989","unstructured":"Vogetseder W, Feichtinger H, Schulz TF, Schwaeble W, Tabaczewski P, Mitterer M, et al. Expression of 7f7antigen, a human adhesion molecule identical to intercellular adhesion molecule 1 (ICAM-1) in human carcinomas and their stromal fibroblasts. 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