{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:07:15Z","timestamp":1765004835138,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>This report describes the occurrence of splenic lymphoma with villous lymphocytes (SLVL) in a 56 year old white female with a family history of chronic lymphocytic leukaemia. Other unusual features included a marked lymphocytosis with counts up to 224 x 10(9)\/l and marked clumping of lymphocytes in EDTA anticoagulated blood. The neoplastic cells were CD19+, CD20+, CD22+, CD22+, IgM+, lambda+, kappa-, CD5-, and CD10-. The spleen had nodular infiltrates of B lymphocytes in the region of the white pulp with minimal red pulp involvement. Electron microscopy of peripheral blood lymphocytes revealed cells with polar cytoplasmic processes. This report underlines the need for detailed analysis, including morphology and immunophenotyping, for each patient with a small B cell lymphoproliferative disorder.<\/jats:p>","DOI":"10.1136\/jcp.48.6.584","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"584-587","source":"Crossref","is-referenced-by-count":17,"title":["Splenic lymphoma with circulating villous lymphocytes."],"prefix":"10.1136","volume":"48","author":[{"suffix":"Jr","given":"F","family":"Imbing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Yuoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1136\/jcp.40.6.642","article-title":"Splenic B cell lymphoma with circulating villous lymphocytes: differential diagnosis of B cell leukaemias with large spleens","volume":"40","author":"Melo, J.V.; Hegde, U.; Parreira, A.; Thompson, I.; Lampert, I.A.; Catovsky, D.","year":"1987","unstructured":"Melo JV, Hegde U, Parreira A, Thompson I, Lampert IA, Catovsky D. Splenic B cell lymphoma with circulating villous lymphocytes: differential diagnosis of B cell leukaemias with large spleens. J Clin Pathol 1987;40:642-51.","journal-title":"J Clin Pathol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/1097-0142(197901)43:1<329::AID-CNCR2820430148>3.0.CO;2-2","article-title":"Malignant lymphoma simulating leukemic reticuloendotheliosis. A clinicopathologic study of ten cases","volume":"43","author":"Neiman, R.S.; Sullivan, A.L.; Jaffe, R.","year":"1979","unstructured":"Neiman RS, Sullivan AL, Jaffe R Malignant lymphoma simulating leukemic reticuloendotheliosis. A clinicopathologic study of ten cases. Cancer 1979;43:329-42.","journal-title":"Cancer"},{"key":"ref_3","first-page":"25","article-title":"Splenomegalic immunocytoma with circulating hairy cells. 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Blood","volume":"83","author":"Matutes, E.; Morilla, R.; Owusu-Ankomah, K.; Houlihan, A.; Catovsky, D.","year":"1994","unstructured":"Matutes E, Morilla R, Owusu-Ankomah K, Houlihan A, Catovsky D. The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B-cell disorders. Blood 1994; 83:1558-62."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"\"206","DOI":"10.1111\/j.1365-2141.1991.tb04417.x","article-title":"Splenic lymphoma with villous lymphocytes: natural history and response to therapy in 50 cases","volume":"78","author":"Mulligan, S.; Matutes, E.; Dearden, C.; Catovsky, D.","year":"1991","unstructured":"Mulligan S, Matutes E, Dearden C, Catovsky D. Splenic lymphoma with villous lymphocytes: natural history and response to therapy in 50 cases. Br J Haematol 1991;78: 206-9. 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