{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:58:36Z","timestamp":1763747916978,"version":"3.45.0"},"reference-count":10,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>A double immunohistochemical technique, incorporating MIB1 and CD3, was used to identify proliferating T cells in paraffin wax sections of normal tonsil and B cell lymphomas. The number of double stained T cells as a percentage of the total T cells was then determined. In normal tonsil and follicular lymphoma the follicle centre and T cell zones were counted independently. In normal tonsil very few T cells in the follicle centre expressed MIB1. Proliferating T cells were concentrated in the T cell zones. The same pattern was observed in follicular lymphoma. In contrast, the percentage of T cells expressing MIB1 was higher in mucosa associated lymphoid tissue type lymphoma and lymphocytic lymphoma, suggesting that T cell activation occurs in these tumours. The highest percentage of MIB1 positive T cells was observed in high grade lymphoma. This suggests that transformation to high grade lymphoma is associated with an increase in T cell activation.<\/jats:p>","DOI":"10.1136\/jcp.48.9.873","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"873-875","source":"Crossref","is-referenced-by-count":7,"title":["Immunohistochemical analysis of T cell proliferation in normal tonsil and B cell lymphoma."],"prefix":"10.1136","volume":"48","author":[{"given":"J","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Isaacson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,9,1]]},"reference":[{"key":"ref_1","first-page":"503","article-title":"This suggests that transformation from low to high grade lymphoma is associated with an increase in T cell activation. The significance of this is not yet known","volume":"139","author":"Diaz, R.I.; Edinger, M.G.; Stoler, M.H.; Tubbs, R.R.","year":"1991","unstructured":"This suggests that transformation from low to high grade lymphoma is associated with an increase in T cell activation. The significance of this is not yet known. 1 Diaz RI, Edinger MG, Stoler MH, Tubbs RR. Activated T- cell subsets in benign lymphoid hyperplasias and B-cell non-Hodgkin's lymphomas. AmJIPathol 1991;139:503-9.","journal-title":"AmJIPathol; Activated T- cell subsets in benign lymphoid hyperplasias and B-cell non-Hodgkin's lymphomas"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.4049\/jimmunol.144.7.2550","article-title":"Induction of proliferation of human follicular (B type) lymphoma cells by cognate interaction with CD4 + T cell clones","volume":"144","author":"Umetsu, D.T.; Esserman, L.; Donlon, T.A.; Dekruyff, R.H.; Levy, R.","year":"1990","unstructured":"Umetsu DT, Esserman L, Donlon TA, Dekruyff RH, Levy R. Induction of proliferation of human follicular (B type) lymphoma cells by cognate interaction with CD4 + T cell clones. 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Cytokine expression by germinal centre cells. J Immunol 1993;150: 39-47.","journal-title":"J Immunol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/00007890-198111000-00018","article-title":"Association of T cells with proliferating cells in lymphoid follicles","volume":"32","author":"Berman, M.A.; Rafiei, S.; Gutman, G.A.","year":"1981","unstructured":"Berman MA, Rafiei S, Gutman GA. Association of T cells with proliferating cells in lymphoid follicles. Transplantation 1981;32:426-30.","journal-title":"Transplantation"},{"key":"ref_8","first-page":"4505","article-title":"T cells within germinal centres are specific for the immunizing antigen","volume":"151","year":"1993","unstructured":"Fuller KA, Kanagawa 0, Nahm MH. T cells within germinal centres are specific for the immunizing antigen. 7 Immunol 1993;151:4505-12."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/367425a0","article-title":"How B and T cells talk to each other","volume":"367","author":"Clark, E.A.; Ledbetter, J.A.","year":"1994","unstructured":"Clark EA, Ledbetter JA. How B and T cells talk to each other. Nature 1994;367:425-8.","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1711680102","article-title":"Proliferating cell nuclear antigen (PCNA) expression in Hodgkin's disease","volume":"168","author":"Schmid, C.; Sweeney, E.; Isaacson, P.G.","year":"1992","unstructured":"Schmid C, Sweeney E, Isaacson PG. Proliferating cell nuclear antigen (PCNA) expression in Hodgkin's disease. 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