{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:14:53Z","timestamp":1765710893433,"version":"3.48.0"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>A case of an ulcerating rheumatoid nodule of the vulva in a 76 year old woman with rheumatoid arthritis complicated by Felty's syndrome is reported. The patient presented with a mass in the vulval region. On clinical examination, she had an ulcerated mass associated with inguinal lymphadenopathy. These findings resulted in a clinical diagnosis of invasive carcinoma of the vulva and an excision biopsy was carried out. On microscopic examination, the lesion showed the characteristic features of a rheumatoid nodule with ulceration of overlying epidermis. Adjacent vessels showed inflammation and fibrinoid necrosis of their walls suggestive of a vasculitis. Awareness of the possibility of ulceration in rheumatoid nodules may facilitate diagnosis and avert unduly aggressive treatment.<\/jats:p>","DOI":"10.1136\/jcp.49.1.85","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"85-87","source":"Crossref","is-referenced-by-count":15,"title":["Ulcerating rheumatoid nodule of the vulva."],"prefix":"10.1136","volume":"49","author":[{"given":"M A","family":"Appleton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/978-1-4757-3889-6_17","article-title":"Diseases of the peritoneum","volume-title":"Blaustein pathology of the female genital tract","author":"Clement, P.B.","year":"1994","unstructured":"Clement PB. 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Arch Pathol 1953;55:475-95.","journal-title":"Arch Pathol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0002-9378(77)90831-6","article-title":"Indolent granulomatous necrosis in patients with previous tubal diathermy","volume":"129","author":"Roberts, J.T.; Roberts, G.T.; Maudsley, R.F.","year":"1977","unstructured":"Roberts JT, Roberts GT, Maudsley RF. Indolent granulomatous necrosis in patients with previous tubal diathermy. Am J Obstet Gynecol 1977;129:112-13.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1136\/jcp.46.10.953","article-title":"Necrotising granulomas of the uterine corpus","volume":"46","author":"Akosa, A.B.; Boret, F.","year":"1993","unstructured":"Akosa AB, Boret F. Necrotising granulomas of the uterine corpus. J Clin Pathol 1993;46:953-5.","journal-title":"J Clin Pathol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/00000478-198411000-00004","article-title":"Necrobiotic granulomas of the uterine cervix","volume":"8","author":"Evans, C.S.; Klein, H.Z.; Goldman, R.L.; Kohout, N.D.","year":"1984","unstructured":"Evans CS, Klein HZ, Goldman RL, Kohout ND. Necrobiotic granulomas of the uterine cervix. Am J Surg Pathol 1984; 8:841-4.","journal-title":"Am J Surg Pathol"},{"key":"ref_16","first-page":"\"380","article-title":"Isolated noninfectious granulomas of the ovary","volume":"2","author":"Herbold, D.R.; Frable, W.J.; Kraus, F.T.","year":"1984","unstructured":"Herbold DR, Frable WJ, Kraus FT. Isolated noninfectious granulomas of the ovary. Int 7 Gynecol Pathol 1984;2: 380-91. 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