{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:22:48Z","timestamp":1765596168461,"version":"3.48.0"},"reference-count":14,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:p>AIMS\/BACKGROUND: Human herpesvirus type 6 (HHV-6) is the aetiological agent of exanthem subitum, and has also been linked with a variety of other diseases. The aim of this study was to investigate the role of HHV-6 in pneumonitis in children. METHODS: Formalin fixed, paraffin wax embedded lung tissue from 33 children (age range two months to 16 years) who died with pneumonitis was subjected to immunohistochemical staining for HHV-6 using an avidin-biotin method. RESULTS: Active HHV-6 infection was demonstrated in four children: a bone marrow transplant recipient with concomitant adenovirus infection, a patient with hepatitis of unknown aetiology, a patient with congenital anomalies, and a patient with congenital immunodeficiency. CONCLUSION: Accurate localisation of HHV-6 is possible in postmortem lung tissue. HHV-6 either alone or in combination with other pathogens may play a role in the development of pneumonitis.<\/jats:p>","DOI":"10.1136\/jcp.49.10.802","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"802-804","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis."],"prefix":"10.1136","volume":"49","author":[{"given":"J A","family":"Hammerling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Lambrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K S","family":"Kehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"Carrigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3527(08)60034-2","article-title":"Human herpesvirus 6: the virus and the research for its role as a human pathogen","volume":"41","author":"Pellett, P.E.; Black, J.B.; Yamamoto, M.","year":"1992","unstructured":"Pellett PE, Black JB, Yamamoto M. Human herpesvirus 6: the virus and the research for its role as a human pathogen. Adv Virus Res 1992;41:1-52.","journal-title":"Adv Virus Res"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1056\/NEJM199408183310703","article-title":"Human herpes virus-6 infection in children","volume":"331","author":"Hall, C.B.; Long, C.E.; Schnabel, K.C.; Caserta, M.T.; McIntyre, K.M.; Costanzo, M.A.","year":"1994","unstructured":"Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, et al. Human herpes virus-6 infection in children. 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