{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:35:03Z","timestamp":1763742903301,"version":"3.45.0"},"reference-count":1,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p>AIM: To investigate the prevalence, and relation to Helicobacter pylori, of parietal cells in the duodenal bulb using a monoclonal antibody directed against H+,K(+)-ATPase (HK12.18). METHODS: Twenty six patients with duodenal ulcer disease and 16 healthy controls were studied. H pylori status was determined by gastric histology and culture and by the 13C-urea breath test. Four biopsy specimens were taken from the duodenal bulb and stained with HK12.18. The presence\/absence and number of parietal cells in the duodenal bulb were assessed blindly by a histopathologist. RESULTS: The overall prevalence of parietal cells in the duodenal bulb was 31% (13\/42) and was similar in patients with duodenal ulcer and in controls, and in H pylori positive and negative subjects. The median (range) number of parietal cells in the duodenal bulb was 7.5 (4-20) parietal cells\/subject, and was similar in all four groups. CONCLUSIONS: The prevalence of parietal cells in the duodenal bulb (31%) is notably higher than previously reported in endoscopic studies, and is in keeping with reports from studies on necropsy\/operative specimens. There was no difference in the prevalence or number of parietal cells in the duodenal bulb between patients with duodenal ulcer and controls, regardless of H pylori status. These findings suggest that parietal cells in the duodenal bulb do not contribute to the pathogenesis of duodenal ulcer.<\/jats:p>","DOI":"10.1136\/jcp.49.4.309","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"309-312","source":"Crossref","is-referenced-by-count":2,"title":["Parietal cells in the duodenal bulb and their relation to Helicobacter pylori infection."],"prefix":"10.1136","volume":"49","author":[{"given":"A W","family":"Harris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Smolka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Waller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Baron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Misiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,4,1]]},"reference":[{"key":"ref_1","unstructured":"Parietal cells in the proximal duodenum were first described by Kaufman in 1906' and noted to be close to Brunner's glands. Further studies have shown their prevalence in the duodenal bulb to vary, ranging from less than 1 %2 to almost 70%4 (table 1). Parietal cells were not found in the duodenum of the fetus and newborn, which suggests that they may be acquired.4 Most of these studies have described gastric heterotopia and not isolated groups of parietal cells in the duodenal bulb. Furthermore, there is some confusion in the literature regarding the difference between gastric heterotopia and gastric metaplasia in the duodenal bulb. The former refers to the presence of full thickness body-type gastric mucosa, and the latter, replacement of intestinal-type surface mucosa with gastric-type epithelium.","article-title":"Parietal cells in the proximal duodenum were first described by Kaufman in 1906' and noted to be close to Brunner's glands. Further studies have shown their prevalence in the duodenal bulb to vary, ranging from less than 1 %2 to almost 70%4 (table 1). Parietal cells were not found in the duodenum of the fetus and newborn, which suggests that they may be acquired.4 Most of these studies have described gastric heterotopia and not isolated groups of parietal cells in the duodenal bulb. Furthermore, there is some confusion in the literature regarding the difference between gastric heterotopia and gastric metaplasia in the duodenal bulb. The former refers to the presence of full thickness body-type gastric mucosa, and the latter, replacement of intestinal-type surface mucosa with gastric-type epithelium"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.49.4.309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:31:21Z","timestamp":1763742681000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.49.4.309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":1,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1996,4,1]]},"published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.1136\/jcp.49.4.309"],"URL":"https:\/\/doi.org\/10.1136\/jcp.49.4.309","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1996,4]]}}}