{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:08:03Z","timestamp":1768626483477,"version":"3.49.0"},"reference-count":10,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:p>A case of a 62 year old Japanese woman with an endometrial adenocarcinoma producing alpha-fetoprotein (AFP) is described. Microscopically, the tumour was composed of a major medullary portion and a minor tubular adenocarcinoma which had invaded the myometrium, the myometrial lymphatics and blood vessels. Neoplastic cells in the medullary portion were polygonal with glycogen-rich cytoplasm. Vascular permeation by neoplastic cells was prominent. Extensive hepatoma-like features were observed. The tumour cells lacked features suggestive of a diagnosis of embryonal carcinoma or endodermal sinus tumour. The production of AFP by the tumour cells was demonstrated immunohistochemically using the PAP technique. Only two cases of AFP producing endometrial adenocarcinomas have been reported previously.<\/jats:p>","DOI":"10.1136\/jcp.49.5.420","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"420-422","source":"Crossref","is-referenced-by-count":37,"title":["Alpha-fetoprotein production by a hepatoid adenocarcinoma of the uterus."],"prefix":"10.1136","volume":"49","author":[{"given":"R","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ishikura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Hareyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Makinoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,5,1]]},"reference":[{"key":"ref_1","first-page":"391","article-title":"Endodermal sinus tumors arising in the endometrium","volume":"56","author":"Pileri, S.; Martinelli, G.; Serra, L.; Bazzocchi, F.","year":"1980","unstructured":"Pileri S, Martinelli G, Serra L, Bazzocchi F. Endodermal sinus tumors arising in the endometrium. Obstet Gynecol 1980;56:391-6.","journal-title":"Obstet Gynecol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0090-8258(88)80015-5","article-title":"Successful treatment of primary endodermal sinus tumor of the endometrium","volume":"31","author":"Ohta, M.; Sakakibara, K.; Mizuno, K.; Kano, T.; Matsuzawa, K.; Tomoda, Y.","year":"1988","unstructured":"Ohta M, Sakakibara K, Mizuno K, Kano T, Matsuzawa K, Tomoda Y, et al. Successful treatment of primary endodermal sinus tumor of the endometrium. Gynecol Oncol 1988;31:357-64.","journal-title":"Gynecol Oncol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/1097-0142(19880801)62:3<620::AID-CNCR2820620330>3.0.CO;2-P","article-title":"Extraovarian pelvic yolk sac tumors","volume":"62","author":"Clement, P.; Young, R.; Scully, R.","year":"1988","unstructured":"Clement P, Young R, Scully R. Extraovarian pelvic yolk sac tumors. Cancer 1988;62:620-6.","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/1097-0142(19900115)65:2<297::AID-CNCR2820650219>3.0.CO;2-E","article-title":"Primary endodermal sinus tumor of the endometrium. A clinicopathologic, immunocytochemical, and ultrastructural study","volume":"65","author":"Joseph, M.; Fellows, F.; Heam, S.","year":"1990","unstructured":"Joseph M, Fellows F, Heam S. Primary endodermal sinus tumor of the endometrium. A clinicopathologic, immunocytochemical, and ultrastructural study. Cancer 1990;65: 297-302.","journal-title":"Cancer"},{"key":"ref_5","first-page":"577","article-title":"A case of mixed mesodermal tumor of the uterus with alpha-fetoprotein production. Jpn J7 Clin Oncol","volume":"15","author":"Kawagoe, K.","year":"1985","unstructured":"Kawagoe K. A case of mixed mesodermal tumor of the uterus with alpha-fetoprotein production. Jpn J7 Clin Oncol 1985;15:577-83."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0090-8258(88)90238-7","article-title":"Alpha-fetoprotein producing endometrial adenocarcinoma: Report of a case","volume":"29","author":"Matsukuma, K.; Tsukamoto, N.","year":"1988","unstructured":"Matsukuma K, Tsukamoto N. Alpha-fetoprotein producing endometrial adenocarcinoma: Report of a case. Gynecol Oncol 1988;29:370-7.","journal-title":"Gynecol Oncol"},{"key":"ref_7","first-page":"399","article-title":"Alpha-fetoprotein-producing papillary adenocarcinoma originating from a uterine body: A case report","volume":"41","author":"Kubo, K.; Lee, G.-H.; Yamauchi, K.; Kitagawa, T.","year":"1991","unstructured":"Kubo K, Lee G-H, Yamauchi K, Kitagawa T. Alpha-fetoprotein-producing papillary adenocarcinoma originating from a uterine body: A case report. Acta PatholJpn 1991; 41:399-403.","journal-title":"Acta PatholJpn"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/ajcp\/99.5.551","article-title":"Comparative immunohistochemical study of primary and metastatic carcinomas of the liver","volume":"99","author":"Ma, C.K.; Zarbo, R.J.; Frierson, H.F.; Lee, M.W.","year":"1993","unstructured":"Ma CK, Zarbo RJ, Frierson HF, Lee MW. Comparative immunohistochemical study of primary and metastatic carcinomas of the liver. Am GClin Pathol 1993;99:551-7.","journal-title":"Am GClin Pathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/1097-0142(19940401)73:7<1919::AID-CNCR2820730724>3.0.CO;2-L","article-title":"Hepatoid adenocarcinoma in the urinary bladder","volume":"73","author":"Sinard, J.; Macleay, L.; Melamed, J.","year":"1994","unstructured":"Sinard J, Macleay L, Melamed J. Hepatoid adenocarcinoma in the urinary bladder. Cancer 1994;73:1919-25.","journal-title":"Cancer"},{"key":"ref_10","first-page":"\"2970","article-title":"Sugar chains of human cord serum ca-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas","volume":"53","author":"Yamashita, K.; Taketa, K.; Nishi, S.; Fukushima, K.; Ohkura, T.","year":"1993","unstructured":"Yamashita K, Taketa K, Nishi S, Fukushima K, Ohkura T. Sugar chains of human cord serum ca-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas. Cancer Res 1993;53:2970-5. J Clin Pathol 1996;49:422-425","journal-title":"Cancer Res"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.49.5.420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:24:29Z","timestamp":1758821069000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.49.5.420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1996,5,1]]},"published-print":{"date-parts":[[1996,5]]}},"alternative-id":["10.1136\/jcp.49.5.420"],"URL":"https:\/\/doi.org\/10.1136\/jcp.49.5.420","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}