{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:22:01Z","timestamp":1791973321136,"version":"4.3.4"},"reference-count":19,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1996,8]]},"abstract":"<jats:p>AIMS: To determine the causes of death in patients with osteogenesis imperfecta, excluding infants with the perinatal lethal form (type II). METHODS: Seventy nine patients with known osteogenesis imperfecta were identified, 37 of whom had been seen clinically in life. Causes of death were identified from death certificates, postmortem reports, medical records, hospital consultants, relatives, and the Brittle Bone Society's records. RESULTS: Patients with the milder types of osteogenesis imperfecta, I and IV, often had a normal lifespan and died of unrelated illnesses such as myocardial infarction and malignancy. In some of these patients and in many patients with the more severe type III disease, it was clear that osteogenesis imperfecta contributed significantly to death, almost certainly to many of the respiratory deaths and to deaths from cardiac failure due to kyphoscoliosis. Osteogenesis imperfecta also caused six deaths, directly or indirectly, due to basilar invagination of the skull. Osteogenesis imperfecta may have contributed to deaths from intracranial bleeding. Apparently minor traumatic incidents may have disastrous consequences in patients with this disorder. CONCLUSIONS: Prompt care for respiratory infections and prevention of trauma in patients with osteogenesis imperfecta is essential.<\/jats:p>","DOI":"10.1136\/jcp.49.8.627","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"627-630","source":"Crossref","is-referenced-by-count":145,"title":["Causes of death in osteogenesis imperfecta."],"prefix":"10.1136","volume":"49","author":[{"given":"S J","family":"McAllion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C R","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1996,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence, D.O.; Senn, A.; Danks, D.M.","year":"1979","unstructured":"Sillence DO, Senn A, Danks DM. Genetic heterogeneity in osteogenesis imperfecta. JMed Genet 1979;16:101-6.","journal-title":"JMed Genet"},{"key":"ref_2","first-page":"11","article-title":"Osteogenesis imperfecta: an expanding panorama of variants","volume":"159","author":"Sillence, D.O.","year":"1981","unstructured":"Sillence DO. Osteogenesis imperfecta: an expanding panorama of variants. Clin Orthop 1981;159:11-25.","journal-title":"Clin Orthop"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/jmg.28.7.433","article-title":"Osteogenesis imperfecta: translation of mutation to phenotype","volume":"28","author":"Byers, P.H.; Wallis, G.A.; Willing, M.C.","year":"1991","unstructured":"Byers PH, Wallis GA, Willing MC. Osteogenesis imperfecta: translation of mutation to phenotype. 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J7 Bone joint Surg Br 1983;65:35-9."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1651-2227.1987.tb10519.x","article-title":"Clinical and radiological features of osteogenesis imperfecta type IVA","volume":"76","author":"Paterson, C.R.; McAllion, S.J.; Shaw, J.W.","year":"1987","unstructured":"Paterson CR, McAllion SJ, Shaw JW. Clinical and radiological features of osteogenesis imperfecta type IVA. Acta PaediatrScand 1987;76:548-52.","journal-title":"Acta PaediatrScand"},{"key":"ref_9","article-title":"International Statistical Classification of Diseases and Related Health Problems. Tenth revision","author":"World Health Organisation","year":"1992","unstructured":"World Health Organisation. International Statistical Classification of Diseases and Related Health Problems. Tenth revision. Geneva: World Health Organisation, 1992."},{"issue":"20","key":"ref_10","article-title":"Population Censuses and Surveys","volume":"2","author":"Office of","year":"1995","unstructured":"Office of Population Censuses and Surveys. Mortality Statistics 1993: Cause (Series DH2 no 20) London: HMSO, 1995.","journal-title":"Mortality Statistics 1993: Cause (Series"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/0002-8703(83)90055-8","article-title":"Cardiovascular abnormalities in osteogenesis imperfecta","volume":"106","author":"White, N.J.; Winearls, C.G.; Smith, R.","year":"1983","unstructured":"White NJ, Winearls CG, Smith R. Cardiovascular abnormalities in osteogenesis imperfecta. 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Neurochirurgia 1985;28:180-1.","journal-title":"Neurochirurgia"},{"issue":"298-30","key":"ref_14","first-page":"1","article-title":"Nontraumatic subdural hematoma in a patient with osteogenesis imperfecta and renal failure","volume":"5","author":"Sayre, M.R.; Roberge, R.J.; Evans, T.C.","year":"1987","unstructured":"Sayre MR, Roberge RJ, Evans TC. Nontraumatic subdural hematoma in a patient with osteogenesis imperfecta and renal failure. Am _J Emerg Med 1987;5:298-30 1.","journal-title":"Am _J Emerg Med"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1227\/00006123-198803000-00029","article-title":"Infantile chronic subdural hematoma with local protrusion of the skull in a case of osteogenesis imperfecta","volume":"22","author":"Tokoro, K.; Nakajima, F.; Yamataki, A.","year":"1988","unstructured":"Tokoro K, Nakajima F, Yamataki A. Infantile chronic subdural hematoma with local protrusion of the skull in a case of osteogenesis imperfecta. 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