{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:20:59Z","timestamp":1770718859529,"version":"3.49.0"},"reference-count":17,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:p>AIMS: To evaluate the expression of the alpha 5 beta 1 integrin fibronectin receptor (FNR), which mediates several processes, including phagocytosis, cell motility and the immune response, on T lymphocytes of patients with HIV-1 infection. METHODS: T lymphocytes were incubated with monoclonal antibody directed against FNR and then with monoclonal antibodies, conjugated with phycoerythrin, directed against CD3, CD4 and CD8 positive cells. Expression of FNR on CD3, CD4 and CD8 positive cells was analysed using flow cytometry. RESULTS: Normal expression of FNR was observed on CD3 positive cells from asymptomatic HIV positive patients and those with AIDS. Increased expression of FNR was observed on CD8 positive cells from asymptomatic HIV positive patients and on CD4 positive cells from patients with AIDS. Increased FNR expression was observed on CD4 positive cells from patients with AIDS, particularly those with opportunistic infections caused by Pneumocystis carinii, Mycobacterium sp, Toxoplasma gondii, and Cryptococcus neoformans. CONCLUSION: Increased expression of FNR on CD8 and CD4 positive cells in asymptomatic HIV positive patients and those with AIDS, respectively, may be an epiphenomenon correlated with lymphocyte activation by HIV-1 or opportunistic infection, Further study is required to determine whether upregulation of FNR expression has a direct role in the pathogenesis of AIDS.<\/jats:p>","DOI":"10.1136\/jcp.49.9.733","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"733-736","source":"Crossref","is-referenced-by-count":4,"title":["Expression of the alpha 5 beta 1 fibronectin receptor on T lymphocytes of patients with HIV-1 infection."],"prefix":"10.1136","volume":"49","author":[{"given":"D","family":"Torre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Ferrario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Issi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pugliese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Speranza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,9,1]]},"reference":[{"key":"ref_1","first-page":"733","volume":"49","author":"Pathol, Clin","year":"1996","unstructured":"Clin Pathol 1996;49:733-736"},{"key":"ref_2","first-page":"4586","article-title":"Transforming garnodwotfhbofatchtosrub, uBnsittismoulfatthees htuhme aenxpfriebsrsoinoenctionf rfeicberpotnoerctbiyn cultured human lung fibroblasts","volume":"263","author":"Roberts, C.J.; Birkenmeier, T.M.; McQuillan, J.J.","year":"1988","unstructured":"Roberts CJ, Birkenmeier TM, McQuillan JJ. Transforming garnodwotfhbofatchtosrub,uBnsittismoulfatthees htuhme aenxpfriebsrsoinoenctionf rfeicberpotnoerctbiyn cultured human lung fibroblasts. Biol Chem 1988; 263:4586-92.","journal-title":"Biol Chem"},{"key":"ref_3","first-page":"531","article-title":"Accessory molecules","volume-title":"Immunology","author":"Shevach, E.M.","year":"1993","unstructured":"Shevach EM. Accessory molecules. In: Paul WE, ed. Fundamental Immunology. 3rd edn. New York: Raven Press, 1993:531-75.","edition":"3rd edn"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.2821619","article-title":"New perspectives in cell adhesion: RGD and integrins","volume":"238","year":"1987","unstructured":"Ruoslahti E, Pierschbacher MD. New perspectives in cell adhesion: RGD and integrins. Science 1987;238:491-7.","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0092-8674(85)90322-8","article-title":"Identification and isolation of a 140 kD cell surface glycoprotein with properties expected of a fibronectin receptor","volume":"40","author":"Pytela, R.; Pierschbacher, M.D.; Ruoslahti, E.","year":"1985","unstructured":"Pytela R, Pierschbacher MD, Ruoslahti E. Identification and isolation of a 140 kD cell surface glycoprotein with properties expected of a fibronectin receptor. Cell 1985; 40:191-8.","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0968-0004(82)90136-0","article-title":"Fibronectin: a molecule with remarkable structural and functional diversity","volume":"7","author":"Ruoslahti, E.; Pierschbacher, M.; Hayman, E.G.; Engvall, E.","year":"1982","unstructured":"Ruoslahti E, Pierschbacher M, Hayman EG, Engvall E. Fibronectin: a molecule with remarkable structural and functional diversity. Trends Biochem Sci 1982;7:188-90.","journal-title":"Trends Biochem Sci"},{"key":"ref_7","first-page":"121","article-title":"T cell fibronectin and mycobacterial adversarial strategy. Int GClin Lab","volume":"23","author":"Godfrey, H.P.","year":"1993","unstructured":"Godfrey HP. T cell fibronectin and mycobacterial adversarial strategy. Int GClin Lab Res 1993;23:121-3.","journal-title":"Res"},{"issue":"1","key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(92)90115-S","article-title":"Integrins: versatility, modulation and signaling in cell adhesion","volume":"69","author":"Hynes, R.O.","year":"1992","unstructured":"Hynes RO. Integrins: versatility, modulation and signaling in cell adhesion. Cell 1992;69:1 1-25.","journal-title":"Cell"},{"key":"ref_9","first-page":"229","article-title":"Mesoderm induction and control of gastrulation in Xenopus laevis: the roles of fibronectin and integrins","volume":"108","author":"Smith, J.C.; Symes, K.; Hynes, R.O.; DeSimone, D.","year":"1990","unstructured":"Smith JC, Symes K, Hynes RO, DeSimone D. Mesoderm induction and control of gastrulation in Xenopus laevis: the roles of fibronectin and integrins. Developmnent 1990;108:229-38.","journal-title":"Developmnent"},{"key":"ref_10","first-page":"560","article-title":"Plasma fibronectin concentration in patients with human immunodeficiency virus infection","volume":"43","author":"Torre, D.; Issi, M.; Sampietro, C.; Fiori, G.P.; Chelazzi, G.; Ferraro, G.","year":"1990","unstructured":"Torre D, Issi M, Sampietro C, Fiori GP, Chelazzi G, Ferraro G. Plasma fibronectin concentration in patients with human immunodeficiency virus infection. C\/in Pathol 1990;43:560-2.","journal-title":"C\/in Pathol"},{"key":"ref_11","first-page":"348","article-title":"Levels of circulating fibronectin receptor in adult and pediatric patients with human immunodeficiency virus type 1 infection. Clin Diagn Lab Immtunol","volume":"1","author":"Torre, D.; Zeroli, C.; Pugliese, A.; Giola, M.; Ferrario, G.; Bonetta, G.","year":"1994","unstructured":"Torre D, Zeroli C, Pugliese A, Giola M, Ferrario G, Bonetta G, et al. Levels of circulating fibronectin receptor in adult and pediatric patients with human immunodeficiency virus type 1 infection. Clin Diagn Lab Immtunol 1994;1:348-50."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1574-695X.1994.tb00434.x","article-title":"Interaction of human plasma fibronectin with viral proteins of human immunodeficiency virus","volume":"8","author":"Torre, D.; Pugliese, A.; Ferrario, G.; Marietti, G.; Forno, B.; Zeroli, C.","year":"1994","unstructured":"Torre D, Pugliese A, Ferrario G, Marietti G, Forno B, Zeroli C. Interaction of human plasma fibronectin with viral proteins of human immunodeficiency virus. FEMS Immunol Med Microbiol 1994;8:127-32.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref_13","article-title":"Acute HIV-1 infection of peripheral blood lymphocytes is associated with enhanced integrin expression. VII International Conference on AIDS","volume-title":"Abstract","author":"Weeks, B.S.; Klotman, M.E.; Kleinman, H.K.; Yamada, K.M.; Klotman, P.E.","year":"1991","unstructured":"Weeks BS, Klotman ME, Kleinman HK, Yamada KM, Klotman PE. Acute HIV-1 infection of peripheral blood lymphocytes is associated with enhanced integrin expression. VII International Conference on AIDS. Florence, Italy, 16-21 June 1991. Abstract MA 1250."},{"key":"ref_14","first-page":"435","article-title":"T cell fibronectin: an unxpected inflammatory lymphokine","volume":"9","author":"Godfrey, H.P.","year":"1990","unstructured":"Godfrey HP. T cell fibronectin: an unxpected inflammatory lymphokine. Lynphokine Res 1990;9:435-47.","journal-title":"Lynphokine Res"},{"key":"ref_15","first-page":"4","article-title":"Fibronectin in parasitic diseases","volume":"9","author":"Wyler, D.J.","year":"1987","unstructured":"Wyler DJ. Fibronectin in parasitic diseases. Rezv Inject Dis 1987;9(Suppl 4):S391-9.","journal-title":"Rezv Inject Dis"},{"key":"ref_16","first-page":"221","article-title":"In vitro binding of Candida albicans veast cells to human fibronectin","volume":"30","author":"Skerl, K.G.; Calderone, R.A.; Segal, E.; Sreevalsan, T.; Scheld, W.M.","year":"1984","unstructured":"Skerl KG, Calderone RA, Segal E, Sreevalsan T, Scheld WM. In vitro binding of Candida albicans veast cells to human fibronectin. Cai JMizcrobiol 1984;30:221-7.","journal-title":"Cai JMizcrobiol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/276718a0","article-title":"Fibronectin binds to Staphylococcus aureus","volume":"276","author":"Kuusela, P.","year":"1978","unstructured":"Kuusela P. Fibronectin binds to Staphylococcus aureus. Natuire 1978;276:718-20.","journal-title":"Natuire"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.49.9.733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:18:43Z","timestamp":1765700323000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.49.9.733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":17,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1996,9,1]]},"published-print":{"date-parts":[[1996,9]]}},"alternative-id":["10.1136\/jcp.49.9.733"],"URL":"https:\/\/doi.org\/10.1136\/jcp.49.9.733","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,9]]}}}