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Low plasma vitamin A concentrations however appear to impair immune responsiveness and have deleterious effects on membrane integrity and mucosal function. Zinc may have similar effects on gut integrity and appears to be particularly useful in the treatment of acute diarrhoea. Low concentrations of other nutrients such as ascorbate and iron, may not necessarily impair immune function. Low plasma ascorbate may assist the removal of iron from plasma and low iron concentrations appear to increase the cytotoxicity of macrophages.<\/jats:p>","DOI":"10.1136\/jcp.50.11.887","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"887-891","source":"Crossref","is-referenced-by-count":60,"title":["Micronutrients and immune function: some recent developments."],"prefix":"10.1136","volume":"50","author":[{"given":"D I","family":"Thurnham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"ref_1","article-title":"Nutrition, immunity and infection. Mechanisms of interactions","author":"Chandra, R.K.; Newberne, P.M.","year":"1977","unstructured":"Chandra RK, Newberne PM. Nutrition, immunity and infection. Mechanisms of interactions. 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