{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:55:04Z","timestamp":1765709704812,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:p>A 35 year old man with a fatal Campylobacter jejuni infection is described. He had HbE\/beta zero thalassaemia and had undergone splenectomy nine months previously for hypersplenism; he also had chronic hepatitis C infection. He presented with high grade fever but no gastrointestinal symptoms and rapidly progressed to septicaemic shock and hepatic encephalopathy despite treatment with penicillin, gentamicin, and, later, chloramphenicol and ceftazidime. Only one case of Campylobacter jejuni septicaemia occurring post-splenectomy has been reported previously, also in an iron overloaded thalassaemia patient. Unusual Gram negative bacilli must be covered by the chosen antibiotic regimen when splenectomised thalassaemic patients present with high grade fever.<\/jats:p>","DOI":"10.1136\/jcp.50.5.436","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"436-437","source":"Crossref","is-referenced-by-count":12,"title":["Fatal Campylobacter jejuni infection in a patient splenectomised for thalassaemia."],"prefix":"10.1136","volume":"50","author":[{"given":"N","family":"Jackson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A R","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Nazim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M N","family":"Win","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,5,1]]},"reference":[{"key":"ref_1","first-page":"430","article-title":"Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force. Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen","volume":"312","year":"1996","unstructured":"Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force. Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. BM3r 1996;312:430-4."},{"issue":"20","key":"ref_2","article-title":"Taxonomy of the genus Campylobacter","volume-title":"Campylobacterinfection in man and animals","volume":"1","author":"Karmali, M.A.; Skirrow, M.B.","year":"1984","unstructured":"Karmali MA, Skirrow MB. Taxonomy of the genus Campylobacter. In: Butzler JP, ed. Campylobacterinfection in man and animals. 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J Infect Dis 1986;153:552-9.","journal-title":"J Infect Dis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"540","DOI":"10.7326\/0003-4819-108-4-540","article-title":"Persistent Campylobacter jejuni infections in patients infected with human immunodeficiency virus (HIV)","volume":"108","author":"Perlman, D.M.; Ampel, N.M.; Schifman, R.B.; Cohn, D.L.; Patton, C.M.; Aguirre, M.L.","year":"1988","unstructured":"Perlman DM, Ampel NM, Schifman RB, Cohn DL, Patton CM, Aguirre ML, et al. Persistent Campylobacter jejuni infections in patients infected with human immunodeficiency virus (HIV). Ann Intern Med 1988;108:540-6.","journal-title":"Ann Intern Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/clinids\/22.1.183","article-title":"Fatal septic shock with multiple organ failure due to Campylobacter jejuni","volume":"22","author":"Meyrieux, V.; Monneret, G.; Lepape, A.; Chomarat, M.; Banssillon, V.","year":"1996","unstructured":"Meyrieux V, Monneret G, Lepape A, Chomarat M, Banssillon V. Fatal septic shock with multiple organ failure due to Campylobacter jejuni. Clin Infect Dis 1996;22:183-4.","journal-title":"Clin Infect Dis"},{"key":"ref_7","first-page":"277","article-title":"Generalised infection with Yersinia enterocolitica and the role of iron","volume":"5","author":"Robins-Browne, R.N.; Robson, A.R.; Koornkof, H.J.","year":"1979","unstructured":"Robins-Browne RN, Robson AR, Koornkof HJ. Generalised infection with Yersinia enterocolitica and the role of iron. Contrib Microbiol Immunol 1979;5:277-82.","journal-title":"Contrib Microbiol Immunol"},{"key":"ref_8","first-page":"223","article-title":"Lipopolysaccharide antigens of Campylobacter jejuni","volume-title":"Current status and future trends","author":"Mills, S.D.; Aspinall, G.O.; McDonald, A.G.; Raju, T.S.; Kurjanczyk, L.A.; Penner, J.L.","year":"1992","unstructured":"Mills SD, Aspinall GO, McDonald AG, Raju TS, Kurjanczyk LA, Penner JL. Lipopolysaccharide antigens of Campylobacter jejuni. In: Nachamkin I, Blaser MJ, Tompkins LS, eds. Campylobacterjejuni: Current status and future trends. Washington, DC: American Society for Microbiology; 1992:223-9."},{"key":"ref_9","article-title":"Toxic shock syndrome caused by Campylobacter intestinalis","volume":"449","author":"JC, Van Der Zwann","year":"1984","unstructured":"Van Der Zwann JC. Toxic shock syndrome caused by Campylobacter intestinalis [letter]. Lancet 1984;i:449.","journal-title":"Lancet"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.50.5.436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:51:12Z","timestamp":1765709472000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.50.5.436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1997,5,1]]},"published-print":{"date-parts":[[1997,5]]}},"alternative-id":["10.1136\/jcp.50.5.436"],"URL":"https:\/\/doi.org\/10.1136\/jcp.50.5.436","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1997,5]]}}}