{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:08:51Z","timestamp":1765724931892,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:p>A 75 year old female presented with a sellar tumour, and was subsequently found also to have a cauda equina tumour, a parietal dural tumour, a pontine tumour, an intradural spinal tumour, and several vertebral body tumours. Histological examination revealed a neuroendocrine tumour forming cell nests surrounded by reticulin. There was moderate nuclear pleomorphism, prominent mitoses, and focal necrosis. Immunohistochemistry showed diffuse positive staining with cytokeratins, chromogranin and 5-hydroxytryptamine, and focal positive staining with S100. This case is an unusual and ultimately insoluble, diagnostic problem; however, the differential diagnoses include pituitary carcinoma, malignant paraganglioma, and atypical carcinoid.<\/jats:p>","DOI":"10.1136\/jcp.50.5.440","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"440-442","source":"Crossref","is-referenced-by-count":11,"title":["Widespread neuroendocrine malignancy within the central nervous system: a diagnostic conundrum."],"prefix":"10.1136","volume":"50","author":[{"given":"D J","family":"Hopster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S F","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Chadwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Geddes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1227\/00006123-199211000-00020","article-title":"Metastatic carcinoid tumour to the orbit and brain","volume":"31","author":"Nida, T.Y.; Hall, W.A.; Glantz, M.J.; Clark, H.B.","year":"1992","unstructured":"Nida TY, Hall WA, Glantz MJ, Clark HB. Metastatic carcinoid tumour to the orbit and brain. Neurosurgery 1992:31:949-52.","journal-title":"Neurosurgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1212\/WNL.36.6.745","article-title":"Neurologic complications of carcinoid","volume":"36","author":"Patchell, R.A.; Posner, J.B.","year":"1986","unstructured":"Patchell RA, Posner JB. Neurologic complications of carcinoid. Neurology 1986;36:745-9.","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1002\/1097-0142(19861015)58:8<1720::AID-CNCR2820580824>3.0.CO;2-U","article-title":"Paraganglioma of the cauda equina region. Clinicopathologic study of 31 cases with special reference to immunocytology and ultrastructure","volume":"58","author":"Sonneland, P.R.L.; Scheithauer, B.W.; LeChago, J.; Crawford, B.G.; Onofrio, B.M.","year":"1986","unstructured":"Sonneland PRL, Scheithauer BW, LeChago J, Crawford BG, Onofrio BM. Paraganglioma of the cauda equina region. Clinicopathologic study of 31 cases with special reference to immunocytology and ultrastructure. Cancer 1986;58: 1720-35.","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0046-8177(79)80008-8","article-title":"Paragangliomas of the head and neck region. A pathologic study of tumours from 71 patients","volume":"10","author":"Lack, E.E.; Cubilla, A.L.; Woodruff, J.M.","year":"1979","unstructured":"Lack EE, Cubilla AL, Woodruff JM. Paragangliomas of the head and neck region. A pathologic study of tumours from 71 patients. Hum Pathol 1979;10: 191-218.","journal-title":"Hum Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00007632-199502000-00021","article-title":"Metastatic paraganglioma causing spinal cord compression","volume":"20","author":"Brodkey, J.A.; Brodkey, J.S.; Watridge, C.B.","year":"1995","unstructured":"Brodkey JA, Brodkey JS, Watridge CB. Metastatic paraganglioma causing spinal cord compression. Spine 1995;20: 367-72.","journal-title":"Spine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1227\/00006123-198806010-00023","article-title":"Malignant growth hormone-secreting pituitary adenoma with haematogenous dural metastasis: case report","volume":"22","author":"Asai, A.; Matsutani, M.; Funada, N.; Takakura, K.","year":"1988","unstructured":"Asai A, Matsutani M, Funada N, Takakura K. Malignant growth hormone-secreting pituitary adenoma with haematogenous dural metastasis: case report. Neurosurgery 1988; 22:1091-4.","journal-title":"Neurosurgery"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0046-8177(85)80127-1","article-title":"Pathobiologic study of pituitary tumours: report of 62 cases with a review of the recent literature","volume":"16","author":"Challa, V.R.; Marshall, R.B.; Hopkins, M.B.; Kelly, D.L.; Civantos, F.","year":"1985","unstructured":"Challa VR, Marshall RB, Hopkins MB, Kelly DL, Civantos F. Pathobiologic study of pituitary tumours: report of 62 cases with a review of the recent literature. Hum Pathol 1985;16:873-84.","journal-title":"Hum Pathol"},{"key":"ref_8","first-page":"93","article-title":"ACTH-producing pituitary carcinoma presenting as the cauda equina syndrome","volume":"119","author":"Frost, A.R.; Tenner, S.; Tenner, M.; Rollhauser, C.; Tabbara, S.O.","year":"1995","unstructured":"Frost AR, Tenner S, Tenner M, Rollhauser C, Tabbara SO. ACTH-producing pituitary carcinoma presenting as the cauda equina syndrome. Arch Pathol Lab Med 1995;119: 93-6.","journal-title":"Arch Pathol Lab Med"},{"key":"ref_9","first-page":"90","article-title":"Primary pituitary carcinoma: a clinical pathological study","volume":"16","author":"Nudleman, K.L.; Choi, B.; Kusske, J.A.","year":"1985","unstructured":"Nudleman KL, Choi B, Kusske JA. Primary pituitary carcinoma: a clinical pathological study. Neurosurgery 1985;16:90-5.","journal-title":"Neurosurgery"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.50.5.440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:05:26Z","timestamp":1765724726000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.50.5.440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1997,5,1]]},"published-print":{"date-parts":[[1997,5]]}},"alternative-id":["10.1136\/jcp.50.5.440"],"URL":"https:\/\/doi.org\/10.1136\/jcp.50.5.440","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1997,5]]}}}