{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:21:37Z","timestamp":1717201297460},"reference-count":15,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>AIM: To determine whether Helicobacter pylori releases cysteamine into gastric juice as cysteamine is known to be ulcerogenic. METHODS: Samples of fasting gastric juice were collected from 22 individuals (four women); 10 subjects were H pylori negative. The presence of infection was confirmed by examination and culture of gastric biopsies. Cysteamine in gastric juice was measured by reversed phase gradient high performance liquid chromatography with a detection limit of 10 mumol\/l. RESULTS: Cysteamine was not detected in any of the gastric juice samples or in extracts of cultured H pylori. CONCLUSIONS: If H pylori produces cysteamine then the amounts produced are insignificant and are unlikely to explain the association between H pylori infection and the development of duodenal ulcer disease.<\/jats:p>","DOI":"10.1136\/jcp.50.9.769","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T04:50:46Z","timestamp":1181364646000},"page":"769-770","source":"Crossref","is-referenced-by-count":0,"title":["Helicobacter pylori does not release cysteamine into gastric juice."],"prefix":"10.1136","volume":"50","author":[{"given":"M B","family":"Leonard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W D","family":"Neithercut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Gillen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K E","family":"McColl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"ref_1","first-page":"1348","article-title":"Campylobacter like organisms in the stomach of patients and healthy individuals","volume":"i:","author":"Langenberg, M.L.; Tytgat, G.N.J.; Schipper, M.E.; Rietra, P.J.G.; Zanen, H.C.","year":"1984","unstructured":"Langenberg ML, Tytgat GNJ, Schipper ME, Rietra PJG, Zanen HC. Campylobacter like organisms in the stomach of patients and healthy individuals [letter]. Lancet 1984;i: 1348.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/jcp.46.1.75","article-title":"Ammonium metabolism and protection from urease mediated destruction in Helicobacter pylori infection","volume":"46","author":"Neithercut, W.D.; Williams, C.; Hossack, M.S.; McColl, K.E.L.","year":"1993","unstructured":"Neithercut WD, Williams C, Hossack MS, McColl KEL. Ammonium metabolism and protection from urease mediated destruction in Helicobacter pylori infection. J Clin Pathol 1993;46:75-8.","journal-title":"J Clin Pathol"},{"key":"ref_3","first-page":"831","article-title":"The urease enzymes of Campylobacter pylori and a related bacterium","volume":"26","author":"Ferrero, R.L.; Hazell, S.L.; Lee, A.","year":"1988","unstructured":"Ferrero RL, Hazell SL, Lee A. The urease enzymes of Campylobacter pylori and a related bacterium. J Med Microbiol 1988;26:831-6.","journal-title":"J Med Microbiol"},{"key":"ref_4","first-page":"959","article-title":"Influence of the bacterial flora of the gut on sulphur amino acid degredation","volume":"20","author":"Martensson, J.; Svensson, H.; Tobiasson, P.","year":"1985","unstructured":"Martensson J, Svensson H, Tobiasson P. Influence of the bacterial flora of the gut on sulphur amino acid degredation. ScandJ Gastroenterol 1985;20:959-65.","journal-title":"ScandJ Gastroenterol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0065-2660(08)60357-0","article-title":"S-aminoacid metabolism and its regulation in Escherichia coli and Salmonella typhimurium","volume":"16","author":"Smith, D.A.","year":"1971","unstructured":"Smith DA. S-aminoacid metabolism and its regulation in Escherichia coli and Salmonella typhimurium. Adv Genet 1971;16:141-65.","journal-title":"Adv Genet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0076-6879(87)43080-2","article-title":"Microbial sulphur amino acids an overview","volume":"143","author":"Soda, K.","year":"1987","unstructured":"Soda K. Microbial sulphur amino acids an overview. Methods Enzymol 1987;143:453-9.","journal-title":"Methods Enzymol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/BF01535759","article-title":"Cysteamine induced inhibition of mucosal and pancreatic alkaline secretion in rat duodenium","volume":"33","author":"Ohe, K.; Miura, Y.; Taoka, Y.; Okada, Y.; Miyoshi, A.","year":"1988","unstructured":"Ohe K, Miura Y, Taoka Y, Okada Y, Miyoshi A. Cysteamine induced inhibition of mucosal and pancreatic alkaline secretion in rat duodenium. Dig Dis Sci 1988;33:330-7.","journal-title":"Dig Dis Sci"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0167-0115(91)90072-O","article-title":"DG. Cysteamine can induce duodenal ulceration in rats without depleton of immunoreactive somatostatin","volume":"36","author":"Kapuscinski, M.","year":"1991","unstructured":"Kapuscinski M, Shulkes A, Green M, Read D, MacLellan DG. Cysteamine can induce duodenal ulceration in rats without depleton of immunoreactive somatostatin. Regul Pept 1991;36:391-406.","journal-title":"Regul Pept"},{"key":"ref_9","first-page":"2540","article-title":"Somatostatin depletion by cysteamine: mechanism and implication for duodenal ulceration","volume":"44","author":"Szabo, S.; Reichlin, S.","year":"1985","unstructured":"Szabo S, Reichlin S. Somatostatin depletion by cysteamine: mechanism and implication for duodenal ulceration. Federation Proceedings 1985;44:2540-5.","journal-title":"Federation Proceedings"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/0140-6736(92)92816-X","article-title":"Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease","volume":"340","author":"Moss, S.F.; Logan, S.; Bishop, A.E.; Polak, J.M.; Colain, J.","year":"1992","unstructured":"Moss SF, Logan S, Bishop AE, Polak JM, Colain J. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet 1992;340:930-2.","journal-title":"Lancet"},{"key":"ref_11","first-page":"738","article-title":"Cholecystokinin in the control of gastric secretion and gastric release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients","volume":"30","author":"Kantirek, J.W.; Kantiret, S.J.; Domschke, W.","year":"1995","unstructured":"Kantirek JW, Kantiret SJ, Domschke W. Cholecystokinin in the control of gastric secretion and gastric release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients. ScandJ7 Gastroenterol 1995;30: 738-44"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/BF01303178","article-title":"Asymptomatic Helicobacter pylori infection impairs pH inhibition of gastrin and acid secretion during second hour of peptone meal stimulation","volume":"38","author":"Tarnosky, P.R.; Kovacs, T.O.G.; Sytrik, B.; Walsh, J.H.","year":"1993","unstructured":"Tarnosky PR, Kovacs TOG, Sytrik B, Walsh JH. Asymptomatic Helicobacter pylori infection impairs pH inhibition of gastrin and acid secretion during second hour of peptone meal stimulation. Dig Dis Sci 1993;38:1681-7.","journal-title":"Dig Dis Sci"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0016-5085(95)90374-7","article-title":"Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease","volume":"109","author":"McColl, K.E.L.","year":"1995","unstructured":"McColl KEL. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology 1995;109:681-91.","journal-title":"Gastroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/clinchem\/28.3.527","article-title":"Rapid assay for amino acids in serum or urine by pre-column derivatization and reversed phase liquid chromatography","volume":"28","author":"Turnell, D.C.; Cooper, J.D.H.","year":"1982","unstructured":"Turnell DC, Cooper JDH. Rapid assay for amino acids in serum or urine by pre-column derivatization and reversed phase liquid chromatography. Clin Chem 1982;28:527-31.","journal-title":"Clin Chem"},{"key":"ref_15","first-page":"1167","article-title":"Campylobacter pylori and duodenal ulcers. The gastric link","volume":"i:","author":"Levi, S.; Beardshall, K.; Haddad, G.; Playford, R.; Ghosh, P.; Calam, J.","year":"1989","unstructured":"Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J. Campylobacter pylori and duodenal ulcers. The gastric link. Lancet 1989;i: 1167-8.","journal-title":"Lancet"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.50.9.769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T23:38:04Z","timestamp":1717198684000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.50.9.769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":15,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1997,9,1]]},"published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1136\/jcp.50.9.769"],"URL":"https:\/\/doi.org\/10.1136\/jcp.50.9.769","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}