{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:34:14Z","timestamp":1783355654691,"version":"3.54.6"},"reference-count":31,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>A 67-year-old woman presented with dry skin, facial hair, hoarse voice, and weight gain. She was hypertensive (168\/ 96 mm Hg), her haemoglobin concentration was 19 g\/l, and haematocrit was 55.7%. The diagnosis of probable secondary polycythaemia was made. Blood testosterone concentration was 44 nmol\/l (normal &lt; 5) and was not suppressed by dexamethasone, suggesting a neoplastic source rather than a pituitary abnormality. Transvaginal ultrasound revealed a hypoechoic solid mass in the left ovary suggestive of a solid ovarian tumour. Hysterectomy and bilateral salpingo-oophorectomy were performed following which testosterone concentration returned to normal. Immunocytochemistry provided evidence of renin synthesis. This is a case of an unusual steroid cell tumour that caused virilisation accompanied by symptoms of secondary polycythaemia presumably as a result of erythropoietin production. This is the second case of a steroid cell tumour with an erythropoietic effect and the first that shows evidence of renin synthesis.<\/jats:p>","DOI":"10.1136\/jcp.51.1.75","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"75-77","source":"Crossref","is-referenced-by-count":14,"title":["A renin secreting ovarian steroid cell tumour associated with secondary polycythaemia."],"prefix":"10.1136","volume":"51","author":[{"given":"M R","family":"Stephen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G B","family":"Lindop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"ref_1","first-page":"215","article-title":"Tumours of the ovary and maldeveloped gonads","volume-title":"Atlas of tumor pathology. 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