{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:34:45Z","timestamp":1770824085096,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>AIMS: To investigate the clinicopathological findings in cases with intraepithelial haemorrhage of the oesophagus (IHO). METHODS: Necropsy records and the histopathology findings in the oesophagus were reviewed for the period 1990 to 1995. Six cases (0.7%) of IHO were found among 919 necropsy cases. Clinical records of these patients and gross and microscopic slides were reviewed in detail. RESULTS: The ages of the IHO cases ranged from 42 to 82 years (average 68 years), with a male to female ratio of 1:2. All cases had underlying haematological disorders with thrombocytopenia, but disseminated intravascular coagulation was not evident in any case. Macroscopically, solitary (two cases) or multiple (four cases) haemorrhagic lesions ranging from 6 to 79 mm in size were identified within the distal oesophagus. Microscopically, there was no inflammatory infiltration, destruction of red blood cells, or submucosal scar formation. CONCLUSIONS: IHO seems to occur shortly before death as a terminal event in haematological disorders. Based on these observations, the term \"terminal IHO\" can be suggested for this type of oesophageal lesion.<\/jats:p>","DOI":"10.1136\/jcp.51.11.838","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"838-841","source":"Crossref","is-referenced-by-count":1,"title":["Intraepithelial haemorrhage of the oesophagus: a terminal event in haematological disorders."],"prefix":"10.1136","volume":"51","author":[{"given":"M","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hirokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Monobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0016-5085(92)90198-8","article-title":"Acute esophageal hemorrhage from a vagal neurilemoma","volume":"102","author":"DeVault, K.R.; Miller, L.S.; Yaghsezian, H.","year":"1992","unstructured":"DeVault KR, Miller LS, Yaghsezian H, et al. Acute esophageal hemorrhage from a vagal neurilemoma. Gastroenterology 1992;102:1059\u201361.","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0003-4975(97)00507-9","article-title":"Acute submucosal esophageal hemorrhage","volume":"64","author":"Nwogu, C.E.; Conlan, A.A.","year":"1997","unstructured":"Nwogu CE, Conlan AA. Acute submucosal esophageal hemorrhage. Ann Thorac Surg 1997;64:247\u20138.","journal-title":"Ann Thorac Surg"},{"key":"ref_3","first-page":"477","article-title":"Esophageal hemorrhage in scleroderma","volume":"46","author":"Berliner, S.D.; Burson, L.","year":"1966","unstructured":"Berliner SD, Burson L. Esophageal hemorrhage in scleroderma. Am J Gastroenterol 1966;46:477\u201380.","journal-title":"Am J Gastroenterol"},{"key":"ref_4","first-page":"1019","article-title":"Esophageal hematoma. Four new cases, a review, and proposed etiology","volume":"26","author":"Shay, S.S.; Berendson, R.A.; Johnson, L.F.","year":"1981","unstructured":"Shay SS, Berendson RA, Johnson LF. Esophageal hematoma. Four new cases, a review, and proposed etiology. Dig Dis Sci 1981;26:1019\u201324.","journal-title":"Dig Dis Sci"},{"key":"ref_5","first-page":"115","article-title":"Esophageal hematoma associated with thrombocytopenia. Gastrointest Radiol","volume":"3","author":"Ashman, F.C.; Hill, M.C.; Saba, G.P.","year":"1978","unstructured":"Ashman FC, Hill MC, Saba GP, et al. Esophageal hematoma associated with thrombocytopenia. Gastrointest Radiol 1978;3:115\u201318."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0016-5107(78)73499-1","article-title":"Spontaneous intramural of hematoma of esophagus","volume":"24","author":"Atefi, D.; Horney, J.T.; Eaton, S.B.","year":"1978","unstructured":"Atefi D, Horney JT, Eaton SB, et al. 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Am J Dig Dis 1970;15:31\u20136.","journal-title":"Am J Dig Dis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2214\/ajr.129.6.1106","article-title":"Massive esophageal hemorrhage in leukemia","volume":"129","author":"Stratemeier, P.H.","year":"1977","unstructured":"Stratemeier PH. Massive esophageal hemorrhage in leukemia. Am J Roentgenol 1977;129:1106\u20137.","journal-title":"Am J Roentgenol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/gut.35.1.130","article-title":"Intramural haematoma of the oesophagus complicating sclerotherapy for varices","volume":"35","author":"Mosimann, F.; Br\u00f6nnimann, B.","year":"1994","unstructured":"Mosimann F, Br\u00f6nnimann B. Intramural haematoma of the oesophagus complicating sclerotherapy for varices. 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