{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:34:22Z","timestamp":1770824062599,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>Malignant ovarian tumours of the fibrothecoma group are rare. The clinicopathological features of a case of ovarian malignant fibrothecoma in which there was metastatic disease in the small intestine and peritoneum at presentation are described. A number of differential diagnoses were considered but positive immunohistochemical staining of the resected ovarian and small intestinal neoplasms with anti-inhibin was of value in confirming a sex cord-stromal tumour and in excluding other lesions. The two tumours were also ultrastructurally identical. Classical malignant fibrothecomas are said to show four or more mitotic figures per 10 high power fields (HPF). Although the intestinal secondary was mitotically active, the primary ovarian tumour contained only one to two mitoses per 10 HPF, showing that formal mitotic counts are not an absolute indicator of malignant behaviour in this group of tumours.<\/jats:p>","DOI":"10.1136\/jcp.51.11.868","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T19:05:02Z","timestamp":1230750302000},"page":"868-871","source":"Crossref","is-referenced-by-count":23,"title":["Malignant fibrothecomatous tumour of the ovary: diagnostic value of anti-inhibin immunostaining."],"prefix":"10.1136","volume":"51","author":[{"given":"W G","family":"McCluggage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D D","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Toner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00004347-198501000-00007","article-title":"Giant fibrosarcoma of the ovary","volume":"4","author":"Miles, P.A.; Kiley, K.C.; Mena, H.","year":"1985","unstructured":"Miles PA, Kiley KC, Mena H. Giant fibrosarcoma of the ovary. Int J Gynecol Pathol 1985;4:83\u20137.","journal-title":"Int J Gynecol Pathol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/1097-0142(19810601)47:11<2663::AID-CNCR2820471124>3.0.CO;2-V","article-title":"Cellular fibromas and fibrosarcomas of the ovary: a comparative clinicopathologic analysis of seventeen cases","volume":"47","author":"Prat, J.; Scully, R.E.","year":"1981","unstructured":"Prat J, Scully RE. Cellular fibromas and fibrosarcomas of the ovary: a comparative clinicopathologic analysis of seventeen cases. Cancer 1981;47:2663\u201370.","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00000478-199701000-00006","article-title":"Fibrosarcoma verses cellular fibroma of the ovary. A comparative study of their proliferative activity and chromosome aberrations using MIB1 immunostaining, DNA flow cytometry, and fluorescence in situ hybridization","volume":"21","author":"Tsuji, T.; Kawauchi, S.; Utsunomiya, T.","year":"1997","unstructured":"Tsuji T, Kawauchi S, Utsunomiya T, et al. Fibrosarcoma verses cellular fibroma of the ovary. A comparative study of their proliferative activity and chromosome aberrations using MIB1 immunostaining, DNA flow cytometry, and fluorescence in situ hybridization. Am J Surg Pathol 1997;21:52\u20139.","journal-title":"Am J Surg Pathol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1002\/1097-0142(197912)44:6<2206::AID-CNCR2820440633>3.0.CO;2-N","article-title":"Ovarian low-grade stromal sarcoma with thecomatous features. 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Am J Surg 1952;84:737\u2013738.","journal-title":"Am J Surg"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1210\/jcem-65-5-954","article-title":"Circulating immunoreactive inhibin levels during the normal menstrual cycle","volume":"65","author":"McLachlan, R.I.; Robertson, D.M.; Burger, H.G.","year":"1987","unstructured":"McLachlan RI, Robertson DM, Burger HG, et al. Circulating immunoreactive inhibin levels during the normal menstrual cycle. J Clin Endocrinol Metab 1987;65:954\u201361.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/00000478-199508000-00008","article-title":"Monoclonal antibodies against inhibin represent key markers of adult granulosa tumors of the ovary even in their metastases","volume":"19","author":"Flemming, P.; Wellmann, A.; Maschek, H.","year":"1995","unstructured":"Flemming P, Wellmann A, Maschek H, et al. Monoclonal antibodies against inhibin represent key markers of adult granulosa tumors of the ovary even in their metastases. Am J Surg Pathol 1995;19:927\u201333.","journal-title":"Am J Surg Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0046-8177(97)90056-3","article-title":"Immunohistochemical staining of ovarian granulosa cell tumors with monoclonal antibody against inhibin","volume":"28","author":"McCluggage, W.G.; Maxwell, P.; Sloan, J.M.","year":"1997","unstructured":"McCluggage WG, Maxwell P, Sloan JM. Immunohistochemical staining of ovarian granulosa cell tumors with monoclonal antibody against inhibin. Hum Pathol 1997;28: 1034\u20138.","journal-title":"Hum Pathol"},{"key":"ref_9","first-page":"375","article-title":"Ultrastructural features of specific human neoplasms with clinicopathologic, immunohistochemical and cytogenetic correlations","volume-title":"transmission electron microscopy of tumours","author":"Erlandson, R.A.","year":"1994","unstructured":"Erlandson RA. Ultrastructural features of specific human neoplasms with clinicopathologic, immunohistochemical and cytogenetic correlations. In: Erlandson RA, ed. Diagnostic transmission electron microscopy of tumours, 1st ed. New York: Raven Press, 1994:375\u20138.","edition":"1st ed"},{"key":"ref_10","first-page":"866","article-title":"Immunohistochemical localisation of placental alkaline phosphatase, carcinoembryonic antigen, and cancer antigen 125 in normal and neoplastic human lung","volume":"46","author":"Nouwen, E.J.; Pullet, D.E.; Edekens, M.W.","year":"1986","unstructured":"Nouwen EJ, Pullet DE, Edekens MW, et al. 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